Human=22255 proteins (73.2% with a domain)
S.pombe=4897 proteins (77.6% with a domain)
Monosiga=9616 proteins (52.2% with a domain)
statistically significant differences are marked in bold (p-value of chi-square test < 0.01 without correction for multiple tests).
| Monosiga | Human | S.pombe | Domain | P-value |
| 94 | 5965 | 37 | IPR007087: Zinc finger, C2H2-type | 0.0e+00, 1.9e-01 |
| 28 | 640 | 1 | IPR003961: Fibronectin, type III | 5.7e-48, 5.6e-04 |
| 173 | 61 | 1 | IPR002909: Cell surface receptor IPT/TIG | 1.5e-47, 2.8e-20 |
| 85 | 727 | 0 | IPR006209: EGF-like | 6.8e-34, 5.0e-11 |
| 41 | 458 | 0 | IPR008160: Collagen triple helix repeat | 2.0e-26, 5.0e-06 |
| 20 | 345 | 0 | IPR013091: EGF calcium-binding | 1.2e-24, 1.4e-03 |
| 328 | 1367 | 41 | IPR001611: Leucine-rich repeat | 2.0e-21, 7.7e-20 |
| 93 | 56 | 0 | IPR013517: FG-GAP | 1.3e-17, 6.4e-12 |
| 20 | 252 | 0 | IPR000436: Sushi/SCR/CCP | 2.9e-16, 1.4e-03 |
| 23 | 0 | 0 | IPR003341: Cysteine rich repeat, tripleX | 3.1e-13, 6.2e-04 |
| 22 | 1 | 0 | IPR013109: Cupin 4 | 8.1e-12, 8.2e-04 |
| 17 | 184 | 0 | IPR002049: EGF-like, laminin | 2.2e-11, 3.3e-03 |
| 56 | 35 | 11 | IPR002860: Glycoside hydrolase, BNR repeat | 7.8e-11, 2.8e-03 |
| 48 | 284 | 0 | IPR002017: Spectrin repeat | 5.1e-10, 7.8e-07 |
| 21 | 4 | 0 | IPR003410: Hyalin | 4.7e-09, 1.1e-03 |
| 102 | 108 | 63 | IPR001650: Helicase, C-terminal | 7.3e-09, 2.3e-01 |
| 34 | 17 | 0 | IPR001290: Poly(ADP-ribose) polymerase, catalytic region | 1.4e-08, 3.2e-05 |
| 20 | 162 | 9 | IPR001781: LIM, zinc-binding | 1.8e-08, 7.6e-01 |
| 25 | 178 | 4 | IPR005821: Ion transport | 3.2e-08, 2.3e-02 |
| 84 | 373 | 94 | IPR000504: RNA-binding region RNP-1 (RNA recognition motif) | 4.7e-08, 9.4e-08 |
| 39 | 223 | 34 | IPR001841: Zinc finger, RING-type | 7.7e-08, 2.1e-02 |
| 12 | 0 | 0 | IPR003883: Extensin-like protein | 1.4e-07, 1.3e-02 |
| 12 | 0 | 1 | IPR002772: Glycoside hydrolase, family 3, C-terminal | 1.4e-07, 4.7e-02 |
| 12 | 0 | 1 | IPR001764: Glycoside hydrolase, family 3, N-terminal | 1.4e-07, 4.7e-02 |
| 42 | 227 | 12 | IPR011498: Kelch | 2.1e-07, 7.4e-02 |
| 98 | 113 | 1 | IPR000980: SH2 motif | 2.9e-07, 6.2e-12 |
| 11 | 0 | 9 | IPR003107: RNA-processing protein, HAT helix | 4.6e-07, 2.9e-01 |
| 11 | 109 | 4 | IPR001092: Basic helix-loop-helix dimerisation region bHLH | 5.5e-07, 5.6e-01 |
| 36 | 194 | 18 | IPR000008: C2 calcium-dependent membrane targeting | 1.7e-06, 9.5e-01 |
| 293 | 474 | 103 | IPR000719: Protein kinase | 1.8e-06, 1.3e-03 |
| 28 | 166 | 23 | IPR013684: Miro-like | 1.9e-06, 8.7e-02 |
| 23 | 12 | 0 | IPR000479: Cation-independent mannose-6-phosphate receptor | 4.7e-06, 6.2e-04 |
| 24 | 146 | 25 | IPR000225: Armadillo | 5.3e-06, 1.1e-02 |
| 15 | 112 | 0 | IPR001304: C-type lectin | 6.7e-06, 5.7e-03 |
| 26 | 16 | 1 | IPR000917: Sulfatase | 7.6e-06, 9.7e-04 |
| 29 | 161 | 22 | IPR013753: Ras | 7.9e-06, 1.6e-01 |
| 23 | 13 | 2 | IPR000782: Beta-Ig-H3/fasciclin | 1.1e-05, 6.5e-03 |
| 7 | 77 | 0 | IPR013099: Ion transport 2 | 1.3e-05, 5.9e-02 |
| 13 | 100 | 10 | IPR001715: Calponin-like actin-binding | 1.6e-05, 3.2e-01 |
| 82 | 322 | 23 | IPR002048: Calcium-binding EF-hand | 1.7e-05, 1.1e-02 |
| 9 | 79 | 6 | IPR002219: Protein kinase C, phorbol ester/diacylglycerol binding | 4.6e-05, 6.1e-01 |
| 16 | 105 | 19 | IPR001965: Zinc finger, PHD-type | 5.0e-05, 1.0e-02 |
| 22 | 14 | 0 | IPR003014: N/apple PAN | 5.3e-05, 8.2e-04 |
| 9 | 2 | 1 | IPR000111: Glycoside hydrolase, clan GH-D | 1.9e-04, 1.1e-01 |
| 35 | 34 | 23 | IPR011704: ATPase associated with various cellular activities, AAA-5 | 2.0e-04, 3.4e-01 |
| 10 | 73 | 5 | IPR000910: HMG1/2 (high mobility group) box | 3.3e-04, 9.7e-01 |
| 7 | 1 | 0 | IPR002372: Pyrrolo-quinoline quinone | 4.1e-04, 5.9e-02 |
| 7 | 1 | 0 | IPR004963: Pectinacetylesterase | 4.1e-04, 5.9e-02 |
| 19 | 14 | 7 | IPR002225: 3-beta hydroxysteroid dehydrogenase/isomerase | 6.1e-04, 4.6e-01 |
| 10 | 4 | 0 | IPR011717: Tetratricopeptide TPR_4 | 7.7e-04, 2.4e-02 |
| 55 | 70 | 38 | IPR011545: DEAD/DEAH box helicase, N-terminal | 7.8e-04, 1.5e-01 |
| 12 | 7 | 7 | IPR001296: Glycosyl transferase, group 1 | 1.7e-03, 7.8e-01 |
| 19 | 16 | 15 | IPR001509: NAD-dependent epimerase/dehydratase | 1.9e-03, 2.0e-01 |
| 10 | 5 | 2 | IPR013525: ABC-2 type transporter | 2.1e-03, 2.1e-01 |
| 8 | 3 | 0 | IPR008030: NmrA-like | 2.1e-03, 4.4e-02 |
| 10 | 63 | 0 | IPR001258: NHL repeat | 2.2e-03, 2.4e-02 |
| 56 | 201 | 0 | IPR013111: EGF, extracellular | 3.5e-03, 9.6e-08 |
| 77 | 260 | 24 | IPR011511: Variant SH3 | 3.6e-03, 3.4e-02 |
| 12 | 8 | 3 | IPR000322: Glycoside hydrolase, family 31 | 3.7e-03, 2.6e-01 |
| 9 | 5 | 3 | IPR005913: dTDP-4-dehydrorhamnose reductase | 5.4e-03, 5.2e-01 |
| 12 | 64 | 4 | IPR000408: Regulator of chromosome condensation, RCC1 | 6.3e-03, 4.6e-01 |
| 27 | 111 | 19 | IPR000571: Zinc finger, CCCH-type | 6.7e-03, 2.8e-01 |
| 136 | 237 | 0 | IPR001478: PDZ/DHR/GLGF | 8.6e-03, 1.0e-16 |
| Monosiga | Human | S.pombe | Domain | |
| 570 | 1254 | 37 | IPR002110: Ankyrin | 3.3e-01, 5.7e-46 |
| 230 | 529 | 0 | IPR002126: Cadherin | 9.4e-01, 4.3e-27 |
| 173 | 61 | 1 | IPR002909: Cell surface receptor IPT/TIG | 1.5e-47, 2.8e-20 |
| 328 | 1367 | 41 | IPR001611: Leucine-rich repeat | 2.0e-21, 7.7e-20 |
| 136 | 237 | 0 | IPR001478: PDZ/DHR/GLGF | 8.6e-03, 1.0e-16 |
| 312 | 702 | 306 | IPR001680: WD-40 repeat | 6.8e-01, 6.2e-16 |
| 12 | 22 | 50 | IPR001313: Pumilio/Puf RNA-binding | 5.2e-01, 7.1e-15 |
| 98 | 113 | 1 | IPR000980: SH2 motif | 2.9e-07, 6.2e-12 |
| 93 | 56 | 0 | IPR013517: FG-GAP | 1.3e-17, 6.4e-12 |
| 28 | 102 | 60 | IPR011701: Major facilitator superfamily MFS_1 | 3.2e-02, 1.0e-11 |
| 85 | 727 | 0 | IPR006209: EGF-like | 6.8e-34, 5.0e-11 |
| 120 | 208 | 13 | IPR001245: Tyrosine protein kinase | 1.2e-02, 5.6e-09 |
| 117 | 309 | 13 | IPR006652: Kelch repeat | 2.3e-01, 1.1e-08 |
| 64 | 107 | 0 | IPR003409: MORN motif | 3.9e-02, 1.2e-08 |
| 84 | 373 | 94 | IPR000504: RNA-binding region RNP-1 (RNA recognition motif) | 4.7e-08, 9.4e-08 |
| 56 | 201 | 0 | IPR013111: EGF, extracellular | 3.5e-03, 9.6e-08 |
| 48 | 284 | 0 | IPR002017: Spectrin repeat | 5.1e-10, 7.8e-07 |
| 41 | 458 | 0 | IPR008160: Collagen triple helix repeat | 2.0e-26, 5.0e-06 |
| 62 | 149 | 67 | IPR001993: Mitochondrial substrate carrier | 8.0e-01, 1.4e-05 |
| 34 | 17 | 0 | IPR001290: Poly(ADP-ribose) polymerase, catalytic region | 1.4e-08, 3.2e-05 |
| 26 | 51 | 36 | IPR003959: AAA ATPase, core | 4.9e-01, 5.4e-05 |
| 112 | 251 | 98 | IPR000357: HEAT | 7.8e-01, 8.6e-05 |
| 83 | 265 | 17 | IPR001849: Pleckstrin-like | 1.1e-02, 4.1e-04 |
| 28 | 640 | 1 | IPR003961: Fibronectin, type III | 5.7e-48, 5.6e-04 |
| 23 | 64 | 0 | IPR001464: Annexin | 4.5e-01, 6.2e-04 |
| 23 | 0 | 0 | IPR003341: Cysteine rich repeat, tripleX | 3.1e-13, 6.2e-04 |
| 23 | 12 | 0 | IPR000479: Cation-independent mannose-6-phosphate receptor | 4.7e-06, 6.2e-04 |
| 8 | 35 | 16 | IPR005828: General substrate transporter | 9.9e-02, 6.6e-04 |
| 22 | 14 | 0 | IPR003014: N/apple PAN | 5.3e-05, 8.2e-04 |
| 22 | 91 | 0 | IPR002035: von Willebrand factor, type A | 1.3e-02, 8.2e-04 |
| 22 | 1 | 0 | IPR013109: Cupin 4 | 8.1e-12, 8.2e-04 |
| 22 | 41 | 28 | IPR006597: Sel1-like | 4.1e-01, 9.0e-04 |
| 26 | 16 | 1 | IPR000917: Sulfatase | 7.6e-06, 9.7e-04 |
| 34 | 55 | 3 | IPR000242: Tyrosine specific protein phosphatase | 9.9e-02, 9.8e-04 |
| 14 | 19 | 21 | IPR001451: Bacterial transferase hexapeptide repeat | 1.3e-01, 1.0e-03 |
| 21 | 4 | 0 | IPR003410: Hyalin | 4.7e-09, 1.1e-03 |
| 37 | 91 | 4 | IPR011510: Sterile alpha motif homology 2 | 7.6e-01, 1.2e-03 |
| 293 | 474 | 103 | IPR000719: Protein kinase | 1.8e-06, 1.3e-03 |
| 20 | 252 | 0 | IPR000436: Sushi/SCR/CCP | 2.9e-16, 1.4e-03 |
| 20 | 345 | 0 | IPR013091: EGF calcium-binding | 1.2e-24, 1.4e-03 |
| 7 | 19 | 14 | IPR001353: 20S proteasome, A and B subunits | 7.2e-01, 1.4e-03 |
| 18 | 19 | 0 | IPR000772: Ricin B lectin | 1.4e-02, 2.5e-03 |
| 34 | 89 | 4 | IPR001660: Sterile alpha motif SAM | 5.4e-01, 2.5e-03 |
| 56 | 35 | 11 | IPR002860: Glycoside hydrolase, BNR repeat | 7.8e-11, 2.8e-03 |
| 76 | 202 | 18 | IPR000048: IQ calmodulin-binding region | 3.1e-01, 2.8e-03 |
| 9 | 24 | 15 | IPR001357: BRCT | 7.2e-01, 2.9e-03 |
| 8 | 17 | 14 | IPR001330: Prenyltransferase/squalene oxidase | 8.4e-01, 3.1e-03 |
| 17 | 184 | 0 | IPR002049: EGF-like, laminin | 2.2e-11, 3.3e-03 |
| 15 | 112 | 0 | IPR001304: C-type lectin | 6.7e-06, 5.7e-03 |
| 23 | 13 | 2 | IPR000782: Beta-Ig-H3/fasciclin | 1.1e-05, 6.5e-03 |
| 7 | 12 | 12 | IPR006935: Type III restriction enzyme, res subunit | 5.3e-01, 6.7e-03 |
| 18 | 25 | 21 | IPR013216: Methyltransferase type 11 | 9.5e-02, 8.0e-03 |