Human=22255 proteins (73.2% with a domain)
S.pombe=4897 proteins (77.6% with a domain)
Monosiga=9616 proteins (52.2% with a domain)
statistically significant differences are marked in bold (p-value of chi-square test < 0.01 without correction for multiple tests).
| Monosiga | Human | S.pombe | Domain | P-value |
| 59 | 705 | 18 | IPR007087: Zinc finger, C2H2-type | 4.2e-41, 5.5e-02 |
| 22 | 1 | 0 | IPR013109: Cupin 4 | 8.1e-12, 8.2e-04 |
| 13 | 162 | 1 | IPR003961: Fibronectin, type III | 6.0e-11, 3.5e-02 |
| 100 | 106 | 62 | IPR001650: Helicase, C-terminal | 1.1e-08, 2.3e-01 |
| 34 | 17 | 0 | IPR001290: Poly(ADP-ribose) polymerase, catalytic region | 1.4e-08, 3.2e-05 |
| 12 | 0 | 1 | IPR002772: Glycoside hydrolase, family 3, C-terminal | 1.4e-07, 4.7e-02 |
| 12 | 0 | 1 | IPR001764: Glycoside hydrolase, family 3, N-terminal | 1.4e-07, 4.7e-02 |
| 39 | 218 | 34 | IPR001841: Zinc finger, RING-type | 1.8e-07, 2.1e-02 |
| 174 | 240 | 14 | IPR002110: Ankyrin | 1.8e-07, 3.1e-14 |
| 11 | 109 | 4 | IPR001092: Basic helix-loop-helix dimerisation region bHLH | 5.5e-07, 5.6e-01 |
| 289 | 464 | 103 | IPR000719: Protein kinase | 1.3e-06, 2.0e-03 |
| 34 | 24 | 0 | IPR013517: FG-GAP | 2.4e-06, 3.2e-05 |
| 28 | 164 | 22 | IPR013684: Miro-like | 2.7e-06, 1.3e-01 |
| 26 | 16 | 1 | IPR000917: Sulfatase | 7.6e-06, 9.7e-04 |
| 29 | 161 | 22 | IPR013753: Ras | 7.9e-06, 1.6e-01 |
| 18 | 8 | 0 | IPR003014: N/apple PAN | 1.5e-05, 2.5e-03 |
| 17 | 113 | 1 | IPR005821: Ion transport | 2.2e-05, 1.1e-02 |
| 12 | 3 | 0 | IPR003410: Hyalin | 2.6e-05, 1.3e-02 |
| 79 | 101 | 1 | IPR000980: SH2 motif | 6.5e-05, 8.4e-10 |
| 53 | 223 | 63 | IPR000504: RNA-binding region RNP-1 (RNA recognition motif) | 7.6e-05, 3.1e-06 |
| 6 | 62 | 2 | IPR001128: Cytochrome P450 | 1.3e-04, 6.0e-01 |
| 37 | 168 | 0 | IPR006209: EGF-like | 1.6e-04, 1.4e-05 |
| 9 | 2 | 1 | IPR000111: Glycoside hydrolase, clan GH-D | 1.9e-04, 1.1e-01 |
| 6 | 0 | 0 | IPR008902: Bacterial alpha-L-rhamnosidase | 1.9e-04, 8.0e-02 |
| 7 | 1 | 0 | IPR004963: Pectinacetylesterase | 4.1e-04, 5.9e-02 |
| 11 | 74 | 0 | IPR001304: C-type lectin | 5.4e-04, 1.8e-02 |
| 19 | 14 | 7 | IPR002225: 3-beta hydroxysteroid dehydrogenase/isomerase | 6.1e-04, 4.6e-01 |
| 12 | 6 | 3 | IPR000322: Glycoside hydrolase, family 31 | 7.5e-04, 2.6e-01 |
| 8 | 61 | 4 | IPR002219: Protein kinase C, phorbol ester/diacylglycerol binding | 7.8e-04, 9.8e-01 |
| 10 | 67 | 6 | IPR001715: Calponin-like actin-binding | 1.0e-03, 7.5e-01 |
| 53 | 68 | 36 | IPR011545: DEAD/DEAH box helicase, N-terminal | 1.1e-03, 1.8e-01 |
| 15 | 10 | 3 | IPR000938: CAP-Gly | 1.2e-03, 1.3e-01 |
| 8 | 58 | 5 | IPR000910: HMG1/2 (high mobility group) box | 1.4e-03, 7.2e-01 |
| 12 | 7 | 7 | IPR001296: Glycosyl transferase, group 1 | 1.7e-03, 7.8e-01 |
| 19 | 16 | 15 | IPR001509: NAD-dependent epimerase/dehydratase | 1.9e-03, 2.0e-01 |
| 51 | 190 | 19 | IPR011511: Variant SH3 | 2.4e-03, 2.4e-01 |
| 15 | 79 | 0 | IPR002126: Cadherin | 2.7e-03, 5.7e-03 |
| 70 | 242 | 10 | IPR001611: Leucine-rich repeat | 3.0e-03, 6.1e-05 |
| 13 | 71 | 4 | IPR001781: LIM, zinc-binding | 3.4e-03, 3.7e-01 |
| 29 | 122 | 12 | IPR000008: C2 calcium-dependent membrane targeting | 3.4e-03, 5.5e-01 |
| 12 | 8 | 1 | IPR002860: Glycoside hydrolase, BNR repeat | 3.7e-03, 4.7e-02 |
| 14 | 73 | 16 | IPR001965: Zinc finger, PHD-type | 4.3e-03, 2.3e-02 |
| 7 | 48 | 9 | IPR000626: Ubiquitin | 4.8e-03, 5.7e-02 |
| 9 | 5 | 3 | IPR005913: dTDP-4-dehydrorhamnose reductase | 5.4e-03, 5.2e-01 |
| 7 | 3 | 1 | IPR000782: Beta-Ig-H3/fasciclin | 6.1e-03, 2.0e-01 |
| 7 | 3 | 0 | IPR008030: NmrA-like | 6.1e-03, 5.9e-02 |
| 49 | 176 | 12 | IPR002048: Calcium-binding EF-hand | 6.2e-03, 2.0e-02 |
| 15 | 74 | 0 | IPR013091: EGF calcium-binding | 6.3e-03, 5.7e-03 |
| 8 | 49 | 0 | IPR000436: Sushi/SCR/CCP | 8.0e-03, 4.4e-02 |
| 34 | 44 | 3 | IPR000242: Tyrosine specific protein phosphatase | 9.9e-03, 9.8e-04 |
| Monosiga | Human | S.pombe | Domain | |
| 174 | 240 | 14 | IPR002110: Ankyrin | 1.8e-07, 3.1e-14 |
| 28 | 102 | 60 | IPR011701: Major facilitator superfamily MFS_1 | 3.2e-02, 1.0e-11 |
| 79 | 101 | 1 | IPR000980: SH2 motif | 6.5e-05, 8.4e-10 |
| 118 | 204 | 13 | IPR001245: Tyrosine protein kinase | 1.2e-02, 9.0e-09 |
| 56 | 133 | 0 | IPR001478: PDZ/DHR/GLGF | 8.7e-01, 9.6e-08 |
| 53 | 223 | 63 | IPR000504: RNA-binding region RNP-1 (RNA recognition motif) | 7.6e-05, 3.1e-06 |
| 37 | 168 | 0 | IPR006209: EGF-like | 1.6e-04, 1.4e-05 |
| 34 | 24 | 0 | IPR013517: FG-GAP | 2.4e-06, 3.2e-05 |
| 34 | 17 | 0 | IPR001290: Poly(ADP-ribose) polymerase, catalytic region | 1.4e-08, 3.2e-05 |
| 70 | 242 | 10 | IPR001611: Leucine-rich repeat | 3.0e-03, 6.1e-05 |
| 31 | 94 | 0 | IPR013111: EGF, extracellular | 1.9e-01, 7.2e-05 |
| 21 | 45 | 31 | IPR003959: AAA ATPase, core | 7.7e-01, 8.3e-05 |
| 116 | 227 | 96 | IPR001680: WD-40 repeat | 1.4e-01, 4.3e-04 |
| 7 | 22 | 15 | IPR001163: Like-Sm ribonucleoprotein, core | 4.8e-01, 6.4e-04 |
| 8 | 35 | 16 | IPR005828: General substrate transporter | 9.9e-02, 6.6e-04 |
| 22 | 1 | 0 | IPR013109: Cupin 4 | 8.1e-12, 8.2e-04 |
| 26 | 16 | 1 | IPR000917: Sulfatase | 7.6e-06, 9.7e-04 |
| 34 | 44 | 3 | IPR000242: Tyrosine specific protein phosphatase | 9.9e-03, 9.8e-04 |
| 7 | 19 | 14 | IPR001353: 20S proteasome, A and B subunits | 7.2e-01, 1.4e-03 |
| 73 | 236 | 16 | IPR001849: Pleckstrin-like | 1.3e-02, 1.7e-03 |
| 289 | 464 | 103 | IPR000719: Protein kinase | 1.3e-06, 2.0e-03 |
| 38 | 87 | 5 | IPR000048: IQ calmodulin-binding region | 9.6e-01, 2.2e-03 |
| 18 | 8 | 0 | IPR003014: N/apple PAN | 1.5e-05, 2.5e-03 |
| 33 | 68 | 4 | IPR006652: Kelch repeat | 5.8e-01, 3.2e-03 |
| 17 | 19 | 0 | IPR000772: Ricin B lectin | 2.6e-02, 3.3e-03 |
| 16 | 54 | 0 | IPR002035: von Willebrand factor, type A | 1.8e-01, 4.3e-03 |
| 15 | 79 | 0 | IPR002126: Cadherin | 2.7e-03, 5.7e-03 |
| 15 | 74 | 0 | IPR013091: EGF calcium-binding | 6.3e-03, 5.7e-03 |
| 7 | 12 | 12 | IPR006935: Type III restriction enzyme, res subunit | 5.3e-01, 6.7e-03 |
| 13 | 19 | 17 | IPR000182: GCN5-related N-acetyltransferase | 2.0e-01, 8.0e-03 |
| 18 | 25 | 21 | IPR013216: Methyltransferase type 11 | 9.5e-02, 8.0e-03 |