6PGD

6-phosphogluconate dehydrogenase, C-terminal domain

• SMART accession number: SM01350
• Description: This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.
• Interpro abstract (IPR006114):

  6-Phosphogluconate dehydrogenase ( EC 1.1.1.44 ) (6PGD) is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways (PPP) [ (PUBMED:2113917) (PUBMED:6641716) ]. Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequences are highly conserved [ (PUBMED:1659648) ]. The protein is a homodimer in which the monomers act independently [ (PUBMED:6641716) ]: each contains a large, mainly alpha-helical domain and a smaller beta-alpha-beta domain, containing a mixed parallel and anti-parallel 6-stranded beta sheet [ (PUBMED:6641716) ]. NADP is bound in a cleft in the small domain, the substrate binding in an adjacent pocket [ (PUBMED:6641716) ].

  This entry represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each. The NAD-binding domain is described in IPR006115 .

• GO process: pentose-phosphate shunt (GO:0006098), oxidation-reduction process (GO:0055114)
• GO function: phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616)

There are 19935 6PGD domains in 19931 proteins in SMART's nrdb database.

Structure (3D structures containing this domain)

3D Structures of 6PGD domains in PDB

PDB code	Title
1pgj	X-RAY STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE FROM THE PROTOZOAN PARASITE T. BRUCEI
1pgn	CRYSTALLOGRAPHIC STUDY OF COENZYME, COENZYME ANALOGUE AND SUBSTRATE BINDING IN 6-PHOSPHOGLUCONATE DEHYDROGENASE: IMPLICATIONS FOR NADP SPECIFICITY AND THE ENZYME MECHANISM
1pgo	CRYSTALLOGRAPHIC STUDY OF COENZYME, COENZYME ANALOGUE AND SUBSTRATE BINDING IN 6-PHOSPHOGLUCONATE DEHYDROGENASE: IMPLICATIONS FOR NADP SPECIFICITY AND THE ENZYME MECHANISM
1pgp	CRYSTALLOGRAPHIC STUDY OF COENZYME, COENZYME ANALOGUE AND SUBSTRATE BINDING IN 6-PHOSPHOGLUCONATE DEHYDROGENASE: IMPLICATIONS FOR NADP SPECIFICITY AND THE ENZYME MECHANISM
1pgq	CRYSTALLOGRAPHIC STUDY OF COENZYME, COENZYME ANALOGUE AND SUBSTRATE BINDING IN 6-PHOSPHOGLUCONATE DEHYDROGENASE: IMPLICATIONS FOR NADP SPECIFICITY AND THE ENZYME MECHANISM
2iyo	Structural characterization of a bacterial 6PDH reveals aspects of specificity, mechanism and mode of inhibition
2iyp	product rup
2iz0	PEX inhibitor-home data
2iz1	6PDH complexed with PEX inhibitor synchrotron data
2jkv	Structure of human Phosphogluconate Dehydrogenase in complex with NADPH at 2.53A
2p4q	Crystal Structure Analysis of Gnd1 in Saccharomyces cerevisiae
2pgd	THE STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE REFINED AT 2 ANGSTROMS RESOLUTION
2w8z	Geobacillus stearothermophilus 6-phosphogluconate with bound 6- phosphogluconate
2w90	Geobacillus stearothermophilus 6-phosphogluconate with bound 6- phosphogluconate
2zya	Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate
2zyd	Dimeric 6-phosphogluconate dehydrogenase complexed with glucose
2zyg	Apo-form of dimeric 6-phosphogluconate dehydrogenase
3fwn	Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate
4e21	The crystal structure of 6-phosphogluconate dehydrogenase from Geobacter metallireducens
4gwg	Crystal Structure Analysis of 6-phosphogluconate dehydrogenase apo-form
4gwk	Crystal structure of 6-phosphogluconate dehydrogenase complexed with 3-phosphoglyceric acid

Links (links to other resources describing this domain)

• INTERPRO: IPR006114
• PFAM: 6PGD