 AgrDStaphylococcal AgrD protein | |
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| SMART ACC: | SM000794 |
| Description: | This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr (PUBMED:11807079). |
| InterPro ACC: | IPR009229 |
| InterPro abstract: | Members of this family of short peptides are precursors to thiolactone (unless Cys is replaced by Ser) cyclic autoinducer peptides, used in quorum-sensing systems in Gram-positive bacteria. The best characterised is the AgrD precursor, processed by the AgrB protein. Nearby proteins regularly encountered include a histidine kinase and a response regulator [ PUBMED:15001569 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 76 AgrD domains in 76 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing AgrD domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AgrD domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Interaction (with the environment) |
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Relevant references for this domain
Primary literature for the AgrD domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a AgrD domain which could be assigned to a KEGG orthologous group, and not all proteins containing AgrD domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.