 AlkA_NAlkA N-terminal domain | |
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| SMART ACC: | SM001009 |
| Description: | This domain is found at the N terminus of bacterial AlkA . AlkA (3-methyladenine-DNA glycosylase II) is a base excision repair glycosylase from Escherichia coli. It removes a variety of alkylated bases from DNA, primarily by removing alkylation damage from duplex and single stranded DNA. AlkA flips a 1-azaribose abasic nucleotide out of DNA. This produces a 66 degrees bend in the DNA and a marked widening of the minor groove (PUBMED:10675345). |
| InterPro ACC: | IPR010316 |
| InterPro abstract: | AlkA (DNA-3-methyladenine glycosylase II) is a base excision repair glycosylase from Escherichia coli. It removes a variety of alkylated bases from DNA, primarily by removing alkylation damage from duplex and single stranded DNA. AlkA is similar in fold and active site location to the bifunctional glycosylase/lyase endonuclease III. This suggests that the two may use similar mechanisms for base … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 6 580 AlkA_N domains in 6 579 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing AlkA_N domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AlkA_N domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transport |
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Relevant references for this domain
Primary literature for the AlkA_N domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a AlkA_N domain which could be assigned to a KEGG orthologous group, and not all proteins containing AlkA_N domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.