 BC10Bladder cancer-related protein BC10 | |
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| SMART ACC: | SM001396 |
| Description: | This family consists of a series of short proteins of around 90 residues in length. The human protein O60629 or BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs) PMID:11920613. The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript. All the editing sites are found in either the 5-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues PMID:15797904. The function of this family is unknown. |
| InterPro ACC: | IPR009598 |
| InterPro abstract: | This family consists of a series of short proteins of around 90 residues in length which includes Apoptosis inducing factor BLCAP from human ( O60629 ), also known as BC10. BCALP acts as a tumor suppressor; it induces growth arrest at G1/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 0 BC10 domains in 0 proteins in SMART's NRDB database. | |
Relevant references for this domain
Primary literature for the BC10 domain is listed below.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a BC10 domain which could be assigned to a KEGG orthologous group, and not all proteins containing BC10 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.