BID_2

Bacterial Ig-like domain 2

• SMART accession number: SM00635
• Description: -
• Interpro abstract (IPR003343):

  Proteins that contain this domain are found in a variety of bacterial and phage surface proteins such as intimins as well as in some uncharacterised eukaryote proteins. Intimin is a bacterial cell-adhesion molecule that mediates the intimate bacterial host-cell interaction. It contains three domains; two immunoglobulin-like domains and a C-type lectin-like module implying that carbohydrate recognition may be important in intimin-mediated cell adhesion [ (PUBMED:10201396) ].

There are 37760 BID_2 domains in 15247 proteins in SMART's nrdb database.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
40.00	map00530	Aminosugars metabolism
40.00	map00051	Fructose and mannose metabolism
20.00	map00500	Starch and sucrose metabolism

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with BID_2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing BID_2 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of BID_2 domains in PDB

PDB code	Title
1cwv	CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN
1e5u	NMR Representative Structure of Intimin-190 (Int190) from Enteropathogenic E. coli
1f00	CRYSTAL STRUCTURE OF C-TERMINAL 282-RESIDUE FRAGMENT OF ENTEROPATHOGENIC E. COLI INTIMIN
1f02	CRYSTAL STRUCTURE OF C-TERMINAL 282-RESIDUE FRAGMENT OF INTIMIN IN COMPLEX WITH TRANSLOCATED INTIMIN RECEPTOR (TIR) INTIMIN-BINDING DOMAIN
2l04	The Solution Structure of the C-terminal Ig-like Domain of the Bacteriophage Lambda Tail Tube Protein
2mh4	Solution structure of the Big domain from Leptospira interrogans
2mog	2MOG
2mqg	2MQG
2n7s	2N7S
2zqk	Crystal structure of intimin-Tir68 complex
2zwk	Crystal structure of intimin-Tir90 complex
3ncw	Crystal structure of EHEC O157:H7 intimin
3ncx	Crystal structure of EHEC O157:H7 intimin mutant
4aq1	Structure of the SbsB S-layer protein of Geobacillus stearothermophilus PV72p2 in complex with nanobody KB6
4hu8	Crystal Structure of a Bacterial Ig-like Domain Containing GH10 Xylanase from Termite Gut
4uic	4UIC
4uid	4UID
4uj6	4UJ6
4uj7	4UJ7
4uj8	4UJ8

Links (links to other resources describing this domain)

• INTERPRO: IPR003343
• PFAM: Big_2