BON bacterial OsmY and nodulation domain
SMART ACC:	SM000749
Description:	-
InterPro ACC:	IPR014004
InterPro abstract:	The BON domain is typically ~60 residues long and has an α/β fold. There is a conserved glycine residue and several hydrophobic regions which suggests a binding function, and, actually, it contains a phospholipid-binding site PUBMED:33847565 PUBMED:33315009 … expand The BON domain is typically ~60 residues long and has an α/β fold. There is a conserved glycine residue and several hydrophobic regions which suggests a binding function, and, actually, it contains a phospholipid-binding site PUBMED:33847565 PUBMED:33315009 ]. Most proteobacteria seem to possess one or two BON-containing proteins, typically of the OsmY-type proteins [ PUBMED:33847565 PUBMED:33315009 PUBMED:27112601 ]; outside of this group the distribution is more disparate. The OsmY protein is an Escherichia coli 20kDa outer membrane or periplasmic protein that is expressed in response to a variety of stress conditions, in particular, helping to provide protection against osmotic shock. One hypothesis is that OsmY prevents shrinkage of the cytoplasmic compartment by contacting the phospholipid interfaces surrounding the periplasmic space. The domain architecture of two BON domains alone suggests that these domains contact the surfaces of phospholipids, with each domain contacting a membrane [ PUBMED:12878000 ]. In the potassium binding protein Kbp, this domain is able to bind K+ [ PUBMED:27112601 ]. collapse
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 14 315 BON domains in 7 147 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing BON domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing BON domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the BON domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a BON domain which could be assigned to a KEGG orthologous group, and not all proteins containing BON domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR014004