This domain is found in the C-terminal of BAP28 proteins [ (PUBMED:15112237) ] (which are involved in nucleolar processing of pre-18S ribosomal RNA and ribosome biosynthesis [ (PUBMED:16531401) ]) and in other BAP28-like proteins.
Family alignment:
There are 1342 BP28CT domains in 1339 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing BP28CT domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with BP28CT domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing BP28CT domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Insights into the evolution of the nucleolus by an analysis of its proteindomain repertoire.
Bioessays. 2004; 26: 567-81
Display abstract
Recently, the first investigation of nucleoli using mass spectrometry ledto the identification of 271 proteins. This represents a rich resource fora comprehensive investigation of nucleolus evolution. We applied aprotocol for the identification of known and novel conserved proteindomains of the nucleolus, resulting in the identification of 115 known and91 novel domain profiles. The phyletic distribution of nucleolar proteindomains in a collection of complete proteomes of selected organisms fromall domains of life confirms the archaebacterial origin of the coremachinery for ribosome maturation and assembly, but also revealssubstantial eubacterial and eukaryotic contributions to nucleolusevolution. We predict that, in different phases of nucleolus evolution,protein domains with different biochemical functions were recruited to thenucleolus. We suggest a model for the late and continuous evolution of thenucleolus in early eukaryotes and argue against an endosymbiotic origin ofthe nucleolus and the nucleus. Supplementary material for this article canbe found on the BioEssays website athttp://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html.
