C6

C6

SMART ACC:SM001048
Description:This domain of unknown function is found in the C. elegans protein Q19522. It is presumed to be an extracellular domain. The C6 domain contains six conserved cysteine residues in most copies of the domain. However some copies of the domain are missing cysteine residues 1 and 3 suggesting that these form a disulphide bridge.
InterPro ACC:IPR002601
InterPro abstract:

This domain of unknown function is found at the C terminus in a number of sequences mainly from Caenorhabditis and related species. It may be an extracellular domain. Most copies of the domain contain six conserved cysteine residues. However some copies of the domain are missing cysteine residues 1 and 3 suggesting that these form a disulphide bridge.

Family alignment:View the Family alignment or the Alignment consensus sequence
There are 566 C6 domains in 265 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing C6 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing C6 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a C6 domain which could be assigned to a KEGG orthologous group, and not all proteins containing C6 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

Links to other resources describing this domain

PfamC6
InterProIPR002601