 C8 | |
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| SMART ACC: | SM000832 |
| Description: | This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. |
| InterPro ACC: | IPR014853 |
| InterPro abstract: | The proteins in this entry contained a domain rich in positionally conserved cysteine residues. Most proteins contains 7 or 8 cysteine residues. The domain is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing IPR001846 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 20 065 C8 domains in 7 663 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing C8 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing C8 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Metabolic |
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KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a C8 domain which could be assigned to a KEGG orthologous group, and not all proteins containing C8 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.