CIMR

Cation-independent mannose-6-phosphate receptor repeat

• SMART accession number: SM01404
• Description: The cation-independent mannose-6-phosphate receptor contains 15 copies of a repeat.

There are 0 CIMR domains in 0 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Cellular role: signalling

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Morgan DO et al.
• Insulin-like growth factor II receptor as a multifunctional binding protein.
• Nature. 1987; 329: 301-7
• Display abstract

The primary structure of human insulin-like growth factor II receptor, predicted from the complementary DNA sequence, reveals a transmembrane receptor moleculewith a large extracellular domain made up of fifteen repeat sequences and a smallregion homologous to the collagen-binding domain of fibronectin. The structuraland biochemical features of the IGF-II receptor appear identical to those of the cation-independent mannose-6-phosphate receptor.

Structure (3D structures containing this domain)

3D Structures of CIMR domains in PDB

PDB code	Title
1q25	Crystal structure of N-terminal 3 domains of CI-MPR
1syo	N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate
1sz0	N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate
2kva	SOLUTION STRUCTURE OF CI-MPR ligand-free domain 5
2kvb	Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside
2l21	chicken IGF2R domain 11
2v5n	STRUCTURE OF HUMAN IGF2R DOMAINS 11-12
2v5o	STRUCTURE OF HUMAN IGF2R DOMAINS 11-14
2v5p	COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II

Links (links to other resources describing this domain)

• PFAM: CIMR