Yeast FCP1 is an essential protein serine phosphatase ( EC 3.1.3.16 ) that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. FCP1 orthologs are present in all known eukaryote proteomes. The N-terminal domain of FCP1 corresponds to the catalytic unit of the phosphatase and has been refered to as the FCP1 homology domain. The FCP1 homology domain, which is a ~180-residue module, is also found in many other proteins of unknown function. It contains a DxDx(T/V) motif preceded by four hydrophobic residues characteristic of a large family of metal-dependent phosphohydrolases and phosphotransferases. The first aspartate residue is likely to participate in catalysis, whereas the second could have a role in substrate recognition [ (PUBMED:9405607) (PUBMED:10445027) (PUBMED:12556522) (PUBMED:10385623) ].
Family alignment:
There are 13391 CPDc domains in 13352 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing CPDc domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CPDc domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing CPDc domain in the selected taxonomic class.
Cellular role (predicted cellular role)
Binding / catalysis: phosphatase
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Systematic identification of novel protein domain families associated with nuclear functions.
Genome Res. 2002; 12: 47-56
Display abstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
