 DDRGK | |
|---|---|
| SMART ACC: | SM001128 |
| Description: | This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif. |
| InterPro ACC: | IPR019153 |
| InterPro abstract: | This is a family of proteins that contain a highly conserved DDRGK motif. In humans, DDRGK domain-containing protein 1 is a substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) [ PUBMED:32160526 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 020 DDRGK domains in 1 020 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing DDRGK domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing DDRGK domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a DDRGK domain which could be assigned to a KEGG orthologous group, and not all proteins containing DDRGK domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.