SMART: DUF3452 domain annotation

DUF3452 Domain of unknown function (DUF3452)

SMART accession number:	SM01367
Description:	This domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes.
Interpro abstract (IPR024599):	This domain is found in N-terminal of the retinoblastoma-associated protein. It is found in association with IPR002720 and IPR002719 . This domain is typically between 124 to 150 amino acids in length and has a single completely conserved residue W that may be functionally important.
Family alignment:	View or

There are 1723 DUF3452 domains in 1722 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing DUF3452 domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DUF3452 domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing DUF3452 domain in the selected taxonomic class.
Structure (3D structures containing this domain)

PDB code	Main view	Title
2qdj		Crystal structure of the Retinoblastoma protein N-domain provides insight into tumor suppression, ligand interaction and holoprotein architecture
4elj		Crystal structure of the inactive retinoblastoma protein phosphorylated at T373

PFAM	DUF3452
INTERPRO	IPR024599

DUF3452