Fmp27_WPPW RNA pol II promoter Fmp27 protein domain Provide feedback
SMART ACC:	SM001216
Description:	Fmp27_WPPW is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation (PUBMED:15314641). It contains characteristic HQR and WPPW sequence motifs and is towards the C-terminal in members which contain Fmp27_SW.
InterPro ACC:	IPR019449
InterPro abstract:	This entry represents a RBG module within FMP27 that contains the conserved HQR and WPPW sequence motifs. Fungal proteins FMP27 (also known as Hob1) and Hob2 (YPR117W) are tube-forming lipid transport proteins which bind to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution [ PUBMED:16823961 … expand This entry represents a RBG module within FMP27 that contains the conserved HQR and WPPW sequence motifs. Fungal proteins FMP27 (also known as Hob1) and Hob2 (YPR117W) are tube-forming lipid transport proteins which bind to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution [ PUBMED:16823961 PUBMED:34415038 PUBMED:35491307 ]. They belong to the repeating β-groove (RBG) superfamily together with VPS13, ATG2, SHIP164, Csf1/BLTP1 proteins, which are all conserved lipid transfer proteins containing long hydrophobic grooves [ PUBMED:35491307 PUBMED:35015055 ]. They all share the same structure consisting of multiple repeating modules comprising five β-sheets followed by a loop. collapse
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 682 Fmp27_WPPW domains in 681 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Fmp27_WPPW domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Fmp27_WPPW domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Transcription

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Fmp27_WPPW domain which could be assigned to a KEGG orthologous group, and not all proteins containing Fmp27_WPPW domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

Links to other resources describing this domain

Pfam	Fmp27_WPPW
InterPro	IPR019449