 HIRAN | |
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| SMART ACC: | SM000910 |
| Description: | The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. HIRAN is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes (PUBMED:16627993). It has been predicted that this protein functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks (PUBMED:16627993) |
| InterPro ACC: | IPR014905 |
| InterPro abstract: | The HIRAN domain (HIP116 Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. HIRAN is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes [ PUBMED:16627993 … expand |
| GO function: | zinc ion binding (GO:0008270), hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818), nucleic acid binding (GO:0003676) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 2 542 HIRAN domains in 2 541 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing HIRAN domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing HIRAN domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transport |
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KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a HIRAN domain which could be assigned to a KEGG orthologous group, and not all proteins containing HIRAN domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.