HTH_MERR helix_turn_helix, mercury resistance
SMART ACC:	SM000422
Description:	-
InterPro ACC:	IPR000551
InterPro abstract:	The merR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 70 residues present in the merR family of transcriptional regulators [ PUBMED:2492496 ]. MerR-type regulators are present in diverse bacterial genera, in the cytoplasm. The helix-turn-helix DNA-binding motif is located in the N-terminal … expand The merR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 70 residues present in the merR family of transcriptional regulators [ PUBMED:2492496 ]. MerR-type regulators are present in diverse bacterial genera, in the cytoplasm. The helix-turn-helix DNA-binding motif is located in the N-terminal part of these transcriptional regulators and is followed by a coiled-coil region. The C-terminal part of merR-type regulators contains effector binding regions that are specific to the effector recognised. Most merR-type transcriptional regulators respond to environmental stimuli, like heavy metals, oxidative stress or antibiotics and a subgroup of metalloregulators are bacterial transcription activators that respond to metal ions [ PUBMED:12829265 ]. Several structures of merR-type transcriptional regulators have been resolved and their N-terminal DNA-binding domains are ascribed to the superfamily of winged-helix proteins, containing a four-helix (H) bundle and a three-stranded antiparallel β-sheet (B) in the topology: B1-H1-H2-B2-B3-H3-H4 [ PUBMED:12186881 ]. The helix-turn-helix motif comprises the first and second helices, the second being called the recognition helix. The HTH is involved in DNA-binding into the major groove, where the recognition helix makes most DNA-contacts. The second DNA-binding element is wing W1, composed of the second and third β-strands and their connecting loop. The third DNA-binding element, wing W2, is not a loop like in typical winged-helix proteins, but another H-T-H motif formed by helices three and four. In a typical merR regulator, the HTH and two wings bind the promoter of the regulated operon between the -35 and -10 regions in a spacer of 19/20 bp and longer than usual, distorting the operator DNA and causing RNA polymerase to initiate transcription [ PUBMED:12829265 ]. Most merR-like transcriptional regulators are dimers. Some proteins known to contain a merR-type HTH domain: Tn501 merR, mercuric resistance operon regulatory protein. In the absence of mercury merR represses transcription by binding tightly, as a dimer, to the 'mer' operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site. Bacillus subtilis bltR, bmrR and mtaN (ywnD), transcriptional activators of the blr and bmr transporters involved in multidrug resistance. Escherichia coli soxR, responds to oxidative stress and autoregulatory controls a superoxide response regulon. Bradyrhizobium japonicum nolA, a transcriptional regulator involved in the genotype-specific nodulation of soybeans. Streptomyces lividans tipA, a transcriptional activator which binds to and is activated by the antibiotic thiostrepton. Escherichia coli zntR, a zinc-responsive regulator of zntA ATPase. Escherichia coli cueR a regulator of the copper efflux regulon. CarA (Q1DDV9) and CarH (Q1DDV8) from Myxococcus xanthus, paralogous repressors that requires B(12) to down-regulation of a light-inducible promoter [ PUBMED:21502508 PUBMED:18315685 ]. TtCarH (Q746J7) from Thermus thermophilus, belongs to a class of photoreceptors that use 5'-deoxyadenosylcobalamin (AdoB12) as the light-sensing chromophore [ PUBMED:23512413 ]. collapse
GO process:	regulation of DNA-templated transcription (GO:0006355)
GO function:	DNA binding (GO:0003677)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 117 543 HTH_MERR domains in 115 376 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing HTH_MERR domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing HTH_MERR domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the HTH_MERR domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a HTH_MERR domain which could be assigned to a KEGG orthologous group, and not all proteins containing HTH_MERR domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR000551
PROSITE	HTH_MERR_FAMILY
Pfam	merR