 IRF-3Interferon-regulatory factor 3 | |
|---|---|
| SMART ACC: | SM001243 |
| Description: | This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection. |
| InterPro ACC: | IPR019471 |
| InterPro abstract: | This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction … expand |
| GO process: | regulation of DNA-templated transcription (GO:0006355) |
| GO function: | DNA-binding transcription factor activity (GO:0003700) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 2 955 IRF-3 domains in 2 950 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing IRF-3 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing IRF-3 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a IRF-3 domain which could be assigned to a KEGG orthologous group, and not all proteins containing IRF-3 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.