LH2 Lipoxygenase homology 2 (beta barrel) domain
SMART ACC:	SM000308
Description:	-
InterPro ACC:	IPR001024
InterPro abstract:	This entry represents a domain found in a variety of membrane or lipid associated proteins. It is known as the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain, is found in a variety of membrane or lipid associated proteins. Structurally, this domain forms a β-sandwich composed of two sheets of four strands each [ PUBMED:10469604 … expand This entry represents a domain found in a variety of membrane or lipid associated proteins. It is known as the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain, is found in a variety of membrane or lipid associated proteins. Structurally, this domain forms a β-sandwich composed of two sheets of four strands each [ PUBMED:10469604 PUBMED:11985859 PUBMED:11412104 ]. The most highly conserved regions coincide with the β-strands, with most of the highly conserved residues being buried within the protein. An exception to this is a surface lysine or arginine that occurs on the surface of the fifth β-strand of the eukaryotic domains. In pancreatic lipase, the lysine in this position forms a salt bridge with the procolipase protein. The conservation of a charged surface residue may indicate the location of a conserved ligand-binding site. It is thought that this domain may mediate membrane attachment via other protein binding partners. collapse
GO function:	protein binding (GO:0005515)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 13 940 LH2 domains in 7 296 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing LH2 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing LH2 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the LH2 domain is listed below. Automatically-derived, secondary literature is also available.

Disease genes where sequence variants are found in this domain

UniRef sequences and OMIM curated human diseases associated with missense mutations within the LH2 domain.

Protein	Description	Disease / phenotype
LIPC_HUMAN		OMIM:151670 : Hepatic lipase deficiency
LIPL_HUMAN		OMIM:238600 : Hyperlipoproteinemia I ; Lipoprotein lipase deficiency ; Chylomicronemia syndrome, familial ; Combined hyperlipemia, familial

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a LH2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing LH2 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

Pfam	lipoxygenase
InterPro	IPR001024
PROSITE	LIPOXYGENASE_1