 Leuk-A4-hydro_CLeukotriene A4 hydrolase, C-terminal | |
|---|---|
| SMART ACC: | SM001263 |
| Description: | Members of this family adopt a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. They are required for the formation of a deep cleft harbouring the catalytic Zn2+ site in Leukotriene A4 hydrolase (PUBMED:11175901). |
| InterPro ACC: | IPR015211 |
| InterPro abstract: | This C-terminal domain is found in peptidases belonging to MEROPS peptidase family M1, particularly: aminopeptidase-1 of Caenorhabditis elegans, aminopeptidase O, aminopeptidase B and the bifunctional leukotriene A4 (LTA-4) hydrolase/aminopeptidase. |
| GO function: | zinc ion binding (GO:0008270), metallopeptidase activity (GO:0008237) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 3 901 Leuk-A4-hydro_C domains in 3 898 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Leuk-A4-hydro_C domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Leuk-A4-hydro_C domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Leuk-A4-hydro_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing Leuk-A4-hydro_C domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
KEGG orthologous groups
3D structures in PDB containing this domain
Links to other resources describing this domain
| Pfam | Leuk-A4-hydro_C |
|---|---|
| InterPro | IPR015211 |