Molybdop_Fe4S4 Molybdopterin oxidoreductase Fe4S4 domain
SMART ACC:	SM000926
Description:	The molybdopterin oxidoreductase Fe4S4 domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain.
InterPro ACC:	IPR006963
InterPro abstract:	The molybdopterin oxidoreductase 4Fe-4S domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain [ PUBMED:9036855 ]. The following proteins contain this domain and belong to the molybdenium (Mo) or tungsten … expand The molybdopterin oxidoreductase 4Fe-4S domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain [ PUBMED:9036855 ]. The following proteins contain this domain and belong to the molybdenium (Mo) or tungsten (W) containing enzyme family, the Mo/W bis-MGD (molybdopterin-guanine-dinucleotide) oxydoreductases [ PUBMED:2015248 PUBMED:3062312 PUBMED:8125918 ]: Escherichia coli respiratory nitrate reductase ( EC:1.7.99.4 ). Escherichia coli anaerobic dimethyl sulfoxide reductase (DMSO reductase). Escherichia coli biotin sulfoxide reductases (genes bisC and bisZ). Methanobacterium formicicum formate dehydrogenase ( EC:1.2.1.2 ). Escherichia coli formate dehydrogenases -H (gene fdhF), -N (gene fdnG) and -O (gene fdoG). Wolinella succinogenes polysulfide reductase chain. Salmonella typhimurium thiosulfate reductase (gene phsA). Escherichia coli trimethylamine-N-oxide reductase ( EC:1.6.6.9 ) (gene torA) [ PUBMED:8022286 ]. Nitrate reductase ( EC:1.7.99.4 ) from Klebsiella pneumoniae (gene nasA), Alcaligenes eutrophus, Escherichia coli, Rhodobacter sphaeroides, Thiosphaera pantotropha (gene napA), and Synechococcus PCC 7942 (gene narB). collapse
GO function:	oxidoreductase activity (GO:0016491)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 56 452 Molybdop_Fe4S4 domains in 56 452 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Molybdop_Fe4S4 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Molybdop_Fe4S4 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Metabolic

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Molybdop_Fe4S4 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Molybdop_Fe4S4 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

Pfam	Molybdop_Fe4S4
InterPro	IPR006963