Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved … expand

Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [ PUBMED:8003968 PUBMED:18310026 ].

On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [ PUBMED:8336670 ] into eight families or clusters, which generally correlate with the nature of the solute bound.

This entry represents a domain found in the solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. This domain can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. MltF is a murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product [ PUBMED:18234673 ].

Familiy 3 members include:

• Histidine-binding protein (gene hisJ) of Escherichia coli and related bacteria. An homologous lipoprotein exists in Neisseria gonorrhoeae.
• Lysine/arginine/ornithine-binding proteins (LAO) (gene argT) of Escherichia coli and related bacteria are involved in the same transport system than hisJ. Both solute-binding proteins interact with a common membrane-bound receptor hisP of the binding protein dependent transport system HisQMP.
• Glutamine-binding proteins (gene glnH) of Escherichia coli and Bacillus stearothermophilus.
• Glutamate-binding protein (gene gluB) of Corynebacterium glutamicum.
• Arginine-binding proteins artI and artJ of Escherichia coli.
• Nopaline-binding protein (gene nocT) from Agrobacterium tumefaciens.
• Octopine-binding protein (gene occT) from Agrobacterium tumefaciens.
• Major cell-binding factor (CBF1) (gene: peb1A) from Campylobacter jejuni.
• Bacteroides nodosus protein aabA.
• Cyclohexadienyl/arogenate dehydratase of Pseudomonas aeruginosa, a periplasmic enzyme which forms an alternative pathway for phenylalanine biosynthesis.
• Escherichia coli L-cystine-binding protein TcyJ, previously known as protein fliY.
• Vibrio harveyi protein patH.
• Bacillus subtilis Probable ABC transporter extracellular-binding protein yckB.
• Bacillus subtilis L-cystine-binding protein TcyA, also known as yckK.

This entry also includes domains found in a number of eukaryotic proteins including Glutamate receptors, Lysine/arginine/ornithine as well as Glutamate/glutamine/aspartate/asparagine-binding periplasmic proteins.