PI3K_C2 Phosphoinositide 3-kinase, region postulated to contain C2 domain
SMART ACC:	SM000142
Description:	Outlier of C2 family.
InterPro ACC:	IPR002420
InterPro abstract:	Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that phosphorylate 4,5-bisphonate (PI(4,5) P2 or PIP2) at the 3-position of the inositol ring, and thus generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which, in turns, initiates a vast array of signaling events. PI3Ks can be grouped intothree classes based on their domain organisation. Class I PI3Ks are heterodimers consisting … expand Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that phosphorylate 4,5-bisphonate (PI(4,5) P2 or PIP2) at the 3-position of the inositol ring, and thus generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which, in turns, initiates a vast array of signaling events. PI3Ks can be grouped intothree classes based on their domain organisation. Class I PI3Ks are heterodimers consisting of a p110 catalytic subunit and a regulatory subunit of either the p85 type (associated with the class IA p110 isoforms p110alpha, p110beta or p110delta) or the p101 type (associated with the class IB p110isoform p110gamma). Common to all catalytic subunits are an N-terminal adaptor-binding domain (ABD) that binds to p85/p101, a Ras- binding domain (RBD), a putative membrane-binding domain (C2), a helical domain of unknown function, and a kinase catalytic domain. Class II PI3Ks lack the ABD domain and are distinguished by a carboxy terminal C2 domain. Class III enzymes lack the ABD and RBD domains [ PUBMED:17626883 PUBMED:18079394 PUBMED:20081827 PUBMED:10580505 ]. The PI3K-type C2 domain is an eight-stranded antiparallel β-sandwich consisting of two four-stranded β-sheets [ PUBMED:17626883 PUBMED:18079394 PUBMED:20081827 PUBMED:10580505 ]. collapse
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 4 758 PI3K_C2 domains in 4 756 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing PI3K_C2 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing PI3K_C2 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Binding / catalysis:	Ca2+-binding (putative)

Relevant references for this domain

Primary literature for the PI3K_C2 domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a PI3K_C2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing PI3K_C2 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR002420