PKS_PP Phosphopantetheine attachment site
SMART ACC:	SM000823
Description:	Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups (PUBMED:5321311).
InterPro ACC:	IPR020806
InterPro abstract:	This entry represents the phosphopantetheine-binding domain from polyketide synthases and related synthase proteins. Polyketide synthases are large multidomain proteins involved in the synthesis of secondary metabolites [ PUBMED:15958783 ]. Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic … expand This entry represents the phosphopantetheine-binding domain from polyketide synthases and related synthase proteins. Polyketide synthases are large multidomain proteins involved in the synthesis of secondary metabolites [ PUBMED:15958783 ]. Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups [ PUBMED:5321311 ]. The amino-terminal region of the ACP proteins is well defined and consists of four α helices arranged in a right-handed bundle held together by interhelical hydrophobic interactions. The Asp-Ser-Leu (DSL) motif is conserved in all of the ACP sequences, and the 4'-PP prosthetic group is covalently linked via a phosphodiester bond to the serine residue. The DSL sequence is present at the amino terminus of helix II, a domain of the protein referred to as the recognition helix and which is responsible for the interaction of ACPs with the enzymes of type II fatty acid synthesis [ PUBMED:11825906 ]. collapse
GO function:	phosphopantetheine binding (GO:0031177)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 98 513 PKS_PP domains in 36 236 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing PKS_PP domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing PKS_PP domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Metabolic

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a PKS_PP domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_PP domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

Pfam	Phosphopantetheine attachment site
InterPro	IPR020806