 RelA_SpoTRegion found in RelA / SpoT proteins | |
|---|---|
| SMART ACC: | SM000954 |
| Description: | The functions of Escherichia coli RelA and SpoT differ somewhat. RelA produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species. |
| InterPro ACC: | IPR007685 |
| InterPro abstract: | This entry includes the catalytic domains of Escherichia coli ppGpp synthetase (RelA), ppGpp synthetase/hydrolase (SpoT), and related proteins. The functions of Escherichia coli RelA and SpoT differ somewhat. RelA ( EC:2.7.6.5 ) produces pppGpp (or ppGpp) from ATP and GTP (or GDP) in response to amino-acid starvation and in association … expand |
| GO process: | guanosine tetraphosphate metabolic process (GO:0015969) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 35 291 RelA_SpoT domains in 35 288 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing RelA_SpoT domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing RelA_SpoT domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the RelA_SpoT domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a RelA_SpoT domain which could be assigned to a KEGG orthologous group, and not all proteins containing RelA_SpoT domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.