S_TKc

Serine/Threonine protein kinases, catalytic domain

• SMART accession number: SM00220
• Description: Phosphotransferases. Serine or threonine-specific kinase subfamily.
• Interpro abstract (IPR000719):

  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [ (PUBMED:3291115) ]:

  • Serine/threonine-protein kinases
  • Tyrosine-protein kinases
  • Dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)

  Protein kinase function is evolutionarily conserved from Escherichia coli to human [ (PUBMED:12471243) ]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [ (PUBMED:12368087) ]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [ (PUBMED:15078142) ], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [ (PUBMED:15320712) ].

  Eukaryotic protein kinases [ (PUBMED:12734000) (PUBMED:7768349) (PUBMED:1835513) (PUBMED:1956325) (PUBMED:3291115) ] are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in the catalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue which is important for the catalytic activity of the enzyme [ (PUBMED:1862342) ].

  This entry represents the protein kinase domain containing the catalytic function of protein kinases [ (PUBMED:1956325) ]. This domain is found in serine/threonine-protein kinases, tyrosine-protein kinases and dual specificity protein kinases.

• GO process: protein phosphorylation (GO:0006468)
• GO function: protein kinase activity (GO:0004672), ATP binding (GO:0005524)

There are 221171 S_TKc domains in 218906 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Binding / catalysis: serine-specific phosphotransferase, threonine-specific phosphotransferase

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Lewis TS, Shapiro PS, Ahn NG
• Signal transduction through MAP kinase cascades.
• Adv Cancer Res. 1998; 74: 49-139

• Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D
• Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
• J Biol Chem. 1996; 271: 26157-64

The discovery of several hundred different protein kinases involved in highly diverse cellular signaling pathways is in stark contrast to the much smaller number of known modulators of cell signaling. Of these, the H series protein kinase inhibitors (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7), N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H8) N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H89)) are frequently used to block signaling pathways in studies of cellular regulation. To elucidate inhibition mechanisms at atomic resolution and to enable structure-based drug design of potential therapeutic modulators of signaling pathways, we determined the crystal structures of corresponding complexes with the cAPK catalytic subunit. Complexes with H7 and H8 (2.2 A) and with H89 (2.3 A) define the binding mode of the isoquinoline-sulfonamide derivatives in the ATP-binding site while demonstrating effects of ligand-induced structural change. Specific interactions between the enzyme and the inhibitors include the isoquinoline ring nitrogen ligating to backbone amide of Val-123 and an inhibitor side chain amide bonding to the backbone carbonyl of Glu-170. The conservation of the ATP-binding site of protein kinases allows evaluation of factors governing general selectivity of these inhibitors among kinases. These results should assist efforts in the design of protein kinase inhibitors with specific properties.

• Hanks SK, Hunter T
• Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
• FASEB J. 1995; 9: 576-96

The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase domains (also known as catalytic domains), which consist of approximately 250-300 amino acid residues. The kinase domains that define this group of enzymes contain 12 conserved subdomains that fold into a common catalytic core structure, as revealed by the 3-dimensional structures of several protein-serine kinases. There are two main subdivisions within the superfamily: the protein-serine/threonine kinases and the protein-tyrosine kinases. A classification scheme can be founded on a kinase domain phylogeny, which reveals families of enzymes that have related substrate specificities and modes of regulation.

• Owen DJ, Noble ME, Garman EF, Papageorgiou AC, Johnson LN
• Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product.
• Structure. 1995; 3: 467-82

BACKGROUND: Control of intracellular events by protein phosphorylation is promoted by specific protein kinases. All the known protein kinase possess a common structure that defines a catalytically competent entity termed the 'kinase catalytic core'. Within this common structural framework each kinase displays its own unique substrate specificity, and a regulatory mechanism that may be modulated by association with other proteins. Structural studies of phosphorylase kinase (Phk), the major substrate of which is glycogen phosphorylase, may be expected to shed light on its regulation. RESULTS: We report two crystal structures of the catalytic core (residues 1-298; Phk gamma trnc) of the gamma-subunit of rabbit muscle phosphorylase kinase: the binary complex with Mn2+/beta-gamma-imidoadenosine 5'-triphosphate (AMPPNP) to a resolution of 2.6 A and the binary complex with Mg2+/ADP to a resolution of 3.0 A. The structures were solved by molecular replacement using the cAMP-dependent protein kinase (cAPK) as a model. CONCLUSIONS: The overall structure of Phk gamma trnc is similar to that of the catalytic core of other protein kinases. It consists of two domians joined on one edge by a 'hinge', with the catalytic site located in the cleft between the domains. Phk gamma trnc is constitutively active, and lacks the need for an activatory phosphorylation event that is essential for many kinases. The structure exhibits an essentially 'closed' conformation of the domains which is similar to that of cAPK complexed with substrates. The phosphorylated residue that is located at the domain interface in many protein kinases and that is believed to stabilize an active conformation is substituted by a glutamate in Phk gamma trnc. The glutamate, in a similar manner to the phosphorylated residue in other protein kinases, interacts with an arginine adjacent to the catalytic aspartate but does not participate in interdomain contacts. The interactions between the enzyme and the nucleotide product of its activity, Mg2+/ADP, explain the inhibitory properties of the nucleotides that are observed in kinetic studies.

• Schulze-Gahmen U et al.
• Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine.
• Proteins. 1995; 22: 378-91

Cyclin-dependent kinases (CDKs) are conserved regulators of the eukaryotic cell cycle with different isoforms controlling specific phases of the cell cycle. Mitogenic or growth inhibitory signals are mediated, respectively, by activation or inhibition of CDKs which phosphorylate proteins associated with the cell cycle. The central role of CDKs in cell cycle regulation makes them a potential new target for inhibitory molecules with anti-proliferative and/or anti-neoplastic effects. We describe the crystal structures of the complexes of CDK2 with a weakly specific CDK inhibitor, N6-(delta 2-isopentenyl)adenine, and a strongly specific inhibitor, olomoucine. Both inhibitors are adenine derivatives and bind in the adenine binding pocket of CDK2, but in an unexpected and different orientation from the adenine of the authentic ligand ATP. The N6-benzyl substituent in olomoucine binds outside the conserved binding pocket and is most likely responsible for its specificity. The structural information from the CDK2-olomoucine complex will be useful in directing the search for the next generation inhibitors with improved properties.

• Zhang J, Zhang F, Ebert D, Cobb MH, Goldsmith EJ
• Activity of the MAP kinase ERK2 is controlled by a flexible surface loop.
• Structure. 1995; 3: 299-307

BACKGROUND: The mitogen-activated protein (MAP) kinase, ERK2, is a tightly regulated enzyme in the ubiquitous Ras-activated protein kinase cascade. ERK2 is activated by phosphorylation at two sites, Y185 and T183, that lie in the phosphorylation lip at the mouth of the catalytic site. To ascertain the role of these two residues in securing the low-activity conformation of the enzymes we have carried out crystallographic analyses and assays of phosphorylation-site mutants of ERK2. RESULTS: The crystal structures of four mutants, T183E (threonine at residue 183 is replaced by glutamate), Y185E, Y185F and the double mutant T183E/Y185E, were determined. When T183 is replaced by glutamate, few conformational changes are observed. By contrast, when Y185 is replaced by glutamate, 19 residues become disordered, including the entire phosphorylation lip and an adjacent loop. The conservative substitution of phenylalanine for Y185 also induces relatively large conformational changes. A binding site for phosphotyrosine in the active enzyme is putatively identified on the basis of the high-resolution refinement of the structure of wild-type ERK2. CONCLUSIONS: The remarkable disorder observed throughout the phosphorylation lip when Y185 is mutated shows that the stability of the phosphorylation lip is rather low. Therefore, only modest amounts of binding energy will be required to dislodge the lip for phosphorylation, and it is likely that these residues will be involved in conformational changes associated with both with binding to kinases and phosphatases and with activation. Furthermore, the low-activity structure is specifically dependent on Y185, whereas there is no such dependency on T183. Both residues, however, participate in forming the active enzyme, contributing to its tight control.

• Taylor SS, Radzio-Andzelm E
• Three protein kinase structures define a common motif.
• Structure. 1994; 2: 345-55

Structural comparisons between cAMP-dependent protein kinase, cyclin-dependent kinase 2 and mitogen-activated protein kinase reveal which features are common to the protein kinase family and which are enzyme-specific.

• Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ
• Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.
• Nature. 1994; 367: 704-11

The structure of the MAP kinase ERK2, a ubiquitous protein kinase target for regulation by Ras and Raf, has been solved in its unphosphorylated low-activity conformation to a resolution of 2.3 A. The two domains of unphosphorylated ERK2 are farther apart than in the active conformation of cAMP-dependent protein kinase and the peptide-binding site is blocked by tyrosine 185, one of the two residues that are phosphorylated in the active enzyme. Activation of ERK2 is thus likely to involve both global and local conformational changes.

• Bossemeyer D, Engh RA, Kinzel V, Ponstingl H, Huber R
• Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
• EMBO J. 1993; 12: 849-59

The crystal structure of the porcine heart catalytic subunit of cAMP-dependent protein kinase in a ternary complex with the MgATP analogue MnAMP-PNP and a pseudosubstrate inhibitor peptide, PKI(5-24), has been solved at 2.0 A resolution from monoclinic crystals of the catalytic subunit isoform CA. The refinement is presently at an R factor of 0.194 and the active site of the molecule is well defined. The glycine-rich phosphate anchor of the nucleotide binding fold motif of the protein kinase is a beta ribbon acting as a flap with conformational flexibility over the triphosphate group. The glycines seem to be conserved to avoid steric clash with ATP. The known synergistic effects of substrate binding can be explained by hydrogen bonds present only in the ternary complex. Implications for the kinetic scheme of binding order are discussed. The structure is assumed to represent a phosphotransfer competent conformation. The invariant conserved residue Asp166 is proposed to be the catalytic base and Lys168 to stabilize the transition state. In some tyrosine kinases Lys168 is functionally replaced by an Arg displaced by two residues in the primary sequence, suggesting invariance in three-dimensional space. The structure supports an in-line transfer with a pentacoordinate transition state at the phosphorus with very few nuclear movements.

• DeBondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH
• Crystal structure of cyclin-dependent kinase 2.
• Nature. 1993; 363: 595-602

Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.

• Zheng J et al.
• Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor.
• Biochemistry. 1993; 32: 2154-61

The structure of a ternary complex of the catalytic subunit of cAMP-dependent protein kinase, MgATP, and a 20-residue inhibitor peptide was determined at a resolution of 2.7 A using the difference Fourier technique starting from the model of the binary complex (Knighton et al., 1991a). The model of the ternary complex was refined using both X-PLOR and TNT to an R factor of 0.212 and 0.224, respectively. The orientation of the nucleotide and the interactions of MgATP with numerous conserved residues at the active site of the enzyme are clearly defined. The unique protein kinase nucleotide binding site consists of a five-stranded antiparallel beta-sheet with the base buried in a hydrophobic site along beta-strands 1 and 2 and fixed by hydrogen bonds to the N6 amino and N7 nitrogens. The small lobe secures the nucleotide via a glycine-rich loop and by ion pairing with Lys72 and Glu91. While the small lobe fixes the nontransferable alpha- and beta-phosphates in this inhibitor complex, the gamma-phosphate is secured by two Mg2+ ions and interacts both directly and indirectly with several residues in the large lobe--Asp184, Asn171, Lys168. Asp166 is positioned to serve as a catalytic base. The structure is correlated with previous chemical evidence, and the features that distinguish this nucleotide binding motif from other nucleotide binding proteins are delineated.

• Knighton DR, Zheng JH, TenEyck LF, Xuong NH, Taylor SS, Sowadski JM
• Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
• Science. 1991; 253: 414-20

The structure of a 20-amino acid peptide inhibitor bound to the catalytic subunit of cyclic AMP-dependent protein kinase, and its interactions with the enzyme, are described. The x-ray crystal structure of the complex is the basis of the analysis. The peptide inhibitor, derived from a naturally occurring heat-stable protein kinase inhibitor, contains an amphipathic helix that is followed by a turn and an extended conformation. The extended region occupies the cleft between the two lobes of the enzyme and contains a five-residue consensus recognition sequence common to all substrates and peptide inhibitors of the catalytic subunit. The helical portion of the peptide binds to a hydrophobic groove and conveys high affinity binding. Loops from both domains converge at the active site and contribute to a network of conserved residues at the sites of magnesium adenosine triphosphate binding and catalysis. Amino acids associated with peptide recognition, nonconserved, extend over a large surface area.

• Knighton DR et al.
• Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
• Science. 1991; 253: 407-14

The crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase complexed with a 20-amino acid substrate analog inhibitor has been solved and partially refined at 2.7 A resolution to an R factor of 0.212. The magnesium adenosine triphosphate (MgATP) binding site was located by difference Fourier synthesis. The enzyme structure is bilobal with a deep cleft between the lobes. The cleft is filled by MgATP and a portion of the inhibitor peptide. The smaller lobe, consisting mostly of amino-terminal sequence, is associated with nucleotide binding, and its largely antiparallel beta sheet architecture constitutes an unusual nucleotide binding motif. The larger lobe is dominated by helical structure with a single beta sheet at the domain interface. This lobe is primarily involved in peptide binding and catalysis. Residues 40 through 280 constitute a conserved catalytic core that is shared by more than 100 protein kinases. Most of the invariant amino acids in this conserved catalytic core are clustered at the sites of nucleotide binding and catalysis.

• Weber IT, Steitz TA, Bubis J, Taylor SS
• Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase.
• Biochemistry. 1987; 26: 343-51

The mammalian cAMP-dependent protein kinases have regulatory (R) subunits that show substantial homology in amino acid sequence with the catabolite gene activator protein (CAP), a cAMP-dependent gene regulatory protein from Escherichia coli. Each R subunit has two in-tandem cAMP binding domains, and the structure of each of these domains has been modeled by analogy with the crystal structure of CAP. Both the type I and II regulatory subunits have been considered, so that four cAMP binding domains have been modeled. The binding of cAMP in general is analogous in all the structures and has been correlated with previous results based on photolabeling and binding of cAMP analogues. The model predicts that the first cAMP binding domain correlates with the previously defined fast dissociation site, which preferentially binds N6-substituted analogues of cAMP. The second domain corresponds to the slow dissociation site, which has a preference for C8-substituted analogues. The model also is consistent with cAMP binding in the syn conformation in both sites. Finally, this model has targeted specific regions that are likely to be involved in interdomain contacts. This includes contacts between the two cAMP binding domains as well as contacts with the amino-terminal region of the R subunit and with the catalytic subunit.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the S_TKc domain.

Protein	Disease
Fibroblast growth factor receptor 3 (P22607) (SMART)	OMIM:134934: Achondroplasia OMIM:100800: Hypochondroplasia OMIM:146000: Thanatophoric dysplasia, types I and II OMIM:187600: Crouzon syndrome with acanthosis nigricans ; Muencke syndrome OMIM:602849: OMIM:600593: Craniosynostosis, Adelaide type
Serine/threonine-protein kinase receptor R3 (P37023) (SMART)	OMIM:601284: Hereditary hemorrhagic telangiectasia-2 OMIM:600376:
Cyclin-dependent kinase 4 (P11802) (SMART)	OMIM:123829: Melanoma
Insulin receptor (P06213) (SMART)	OMIM:147670: Leprechaunism OMIM:246200: Rabson-Mendenhall syndrome OMIM:262190: Diabetes mellitus, insulin-resistant, with acanthosis nigricans
Mast/stem cell growth factor receptor Kit (P10721) (SMART)	OMIM:164920: Piebaldism ; Mast cell leukemia ; Mastocytosis with associated hematologic disorder ; Germ cell tumors OMIM:273300:
Tyrosine-protein kinase BTK (Q06187) (SMART)	OMIM:300300: Agammaglobulinemia, type 1, X-linked ; ?XLA and isolated growth hormone deficiency OMIM:307200:
Serine/threonine-protein kinase STK11 (Q15831) (SMART)	OMIM:602216: Peutz-Jeghers syndrome OMIM:175200:
Ribosomal protein S6 kinase alpha-3 (P51812) (SMART)	OMIM:300075: Coffin-Lowry syndrome OMIM:303600: Mental retardation, X-linked nonspecific, type 19
High affinity nerve growth factor receptor (P04629) (SMART)	OMIM:191315: Insensitivity to pain, congenital, with anhidrosis OMIM:256800: Medullary thyroid carcinoma, familial OMIM:155240:
Protein kinase C gamma type (P05129) (SMART)	OMIM:176980: PROTEIN KINASE C, GAMMA; PRKCG
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (P15735) (SMART)	OMIM:172471: Glycogenosis, hepatic, autosomal
Retinal guanylyl cyclase 1 (Q02846) (SMART)	OMIM:601777: Cone dystrophy, progressive OMIM:600179: Leber congenital amaurosis, type I OMIM:204000: Cone-rod dystrophy 6 OMIM:601777:
TGF-beta receptor type-2 (P37173) (SMART)	OMIM:190182: Colon cancer ; Colorectal cancer, hereditary nonpolyposis, type 6 OMIM:114500: Esophageal cancer OMIM:133239:
Tyrosine-protein kinase ZAP-70 (P43403) (SMART)	OMIM:176947: Selective T-cell defect
Angiopoietin-1 receptor (Q02763) (SMART)	OMIM:600221: Venous malformations, multiple cutaneous and mucosal OMIM:600195:
Rhodopsin kinase (Q15835) (SMART)	OMIM:180381: Oguchi disease-2 OMIM:258100:
Hepatocyte growth factor receptor (P08581) (SMART)	OMIM:164860: Renal cell carcinoma, papillary, familial and sporadic OMIM:605074: Hepatocellular carcinoma, childhood type OMIM:114550:
Proto-oncogene tyrosine-protein kinase receptor Ret (P07949) (SMART)	OMIM:164761: Multiple endocrine neoplasia IIA OMIM:171400: Medullary thyroid carcinoma OMIM:155240: Multiple endocrine neoplasia IIB OMIM:162300: Hirschsprung disease OMIM:142623: OMIM:188550: Thyroid papillary carcinoma

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
7.46	map04010	MAPK signaling pathway
3.88	map04912	GnRH signaling pathway
3.73	map04012	ErbB signaling pathway
3.58	map04910	Insulin signaling pathway
3.55	map04914	Progesterone-mediated oocyte maturation
3.54	map04510	Focal adhesion
2.72	map04720	Long-term potentiation
2.65	map04620	Toll-like receptor signaling pathway
2.62	map04310	Wnt signaling pathway
2.62	map04540	Gap junction
2.57	map04664	Fc epsilon RI signaling pathway
2.56	map04370	VEGF signaling pathway
2.53	map04150	mTOR signaling pathway
2.40	map04916	Melanogenesis
2.23	map04810	Regulation of actin cytoskeleton
2.10	map05214	Glioma
2.06	map04020	Calcium signaling pathway
2.04	map05223	Non-small cell lung cancer
2.01	map00632	Benzoate degradation via CoA ligation
2.01	map00562	Inositol phosphate metabolism
2.00	map05211	Renal cell carcinoma
1.97	map04530	Tight junction
1.92	map04360	Axon guidance
1.70	map05215	Prostate cancer
1.67	map05221	Acute myeloid leukemia
1.55	map04110	Cell cycle
1.52	map05212	Pancreatic cancer
1.51	map05213	Endometrial cancer
1.51	map04650	Natural killer cell mediated cytotoxicity
1.48	map05210	Colorectal cancer
1.48	map04730	Long-term depression
1.46	map05120	Epithelial cell signaling in Helicobacter pylori infection
1.42	map04670	Leukocyte transendothelial migration
1.39	map04920	Adipocytokine signaling pathway
1.36	map05220	Chronic myeloid leukemia
1.35	map04660	T cell receptor signaling pathway
1.29	map05218	Melanoma
1.24	map04740	Olfactory transduction
1.18	map05219	Bladder cancer
1.02	map04210	Apoptosis
1.01	map04520	Adherens junction
1.01	map04350	TGF-beta signaling pathway
0.92	map04340	Hedgehog signaling pathway
0.87	map04115	p53 signaling pathway
0.81	map04111	Cell cycle - yeast
0.80	map05216	Thyroid cancer
0.77	map04930	Type II diabetes mellitus
0.70	map04320	Dorso-ventral axis formation
0.68	map05222	Small cell lung cancer
0.65	map04140	Regulation of autophagy
0.61	map04742	Taste transduction
0.59	map04662	B cell receptor signaling pathway
0.46	map04630	Jak-STAT signaling pathway
0.43	map04070	Phosphatidylinositol signaling system
0.31	map05217	Basal cell carcinoma
0.19	map03320	PPAR signaling pathway
0.18	map05010	Alzheimer's disease
0.09	map04120	Ubiquitin mediated proteolysis
0.03	map00540	Lipopolysaccharide biosynthesis

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with S_TKc domain which could be assigned to a KEGG orthologous group, and not all proteins containing S_TKc domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of S_TKc domains in PDB

PDB code	Title
1a06	CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
1a9u	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580
1apm	2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT
1aq1	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
1atp	2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR
1b38	HUMAN CYCLIN-DEPENDENT KINASE 2
1b39	HUMAN CYCLIN-DEPENDENT KINASE 2 PHOSPHORYLATED ON THR 160
1bi7	MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX
1bi8	MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX
1bkx	A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY
1bl6	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995
1bl7	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025
1blx	P19INK4D/CDK6 COMPLEX
1bmk	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655
1buh	CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1
1bx6	CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
1cdk	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C
1ckp	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B
1cm8	PHOSPHORYLATED MAP KINASE P38-GAMMA
1cmk	CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS
1ctp	STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION
1daw	CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP
1day	CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP
1di8	THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE
1di9	THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE
1dm2	HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE
1ds5	DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.
1e1v	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058
1e1x	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027
1e9h	Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound
1erk	STRUCTURE OF SIGNAL-REGULATED KINASE
1f0q	CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF PROTEIN KINASE CK2 IN COMPLEX WITH THE NUCLEOTIDE COMPETITIVE INHIBITOR EMODIN
1f3m	CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
1f5q	CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2
1fin	CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
1fmo	CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE
1fot	STRUCTURE OF THE UNLIGANDED CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM SACCHAROMYCES CEREVISIAE
1fq1	CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2
1fvt	THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR
1fvv	THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
1g3n	STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX
1g5s	CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717
1gih	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
1gii	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
1gij	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
1gng	Glycogen synthase kinase-3 beta (GSK3) complex with FRATtide peptide
1gol	COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
1gy3	pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate
1gz8	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 2-Amino-6-(3'-methyl-2'-oxo)butoxypurine
1gzk	Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
1gzn	Structure of PKB kinase domain
1gzo	Structure of protein kinase B unphosphorylated
1h00	CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor
1h01	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor
1h07	CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor
1h08	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor
1h0v	Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-Amino-6-[(R)-pyrrolidino-5'-yl]methoxypurine
1h0w	Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-Amino-6-[cyclohex-3-enyl]methoxypurine
1h1p	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058
1h1q	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094
1h1r	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086
1h1s	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6102
1h1w	High resolution crystal structure of the human PDK1 catalytic domain
1h24	CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
1h25	CDK2/CyclinA in complex with an 11-residue recruitment peptide from E2F
1h26	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
1h27	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27
1h28	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107
1h4l	Structure and regulation of the CDK5-p25(nck5a) complex
1h8f	Glycogen Synthase Kinase 3 beta.
1hck	HUMAN CYCLIN-DEPENDENT KINASE 2
1hcl	HUMAN CYCLIN-DEPENDENT KINASE 2
1how	THE X-RAY CRYSTAL STRUCTURE OF SKY1P, AN SR PROTEIN KINASE IN YEAST
1i09	STRUCTURE OF GLYCOGEN SYNTHASE KINASE-3 (GSK3B)
1ia8	THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1
1ian	HUMAN P38 MAP KINASE INHIBITOR COMPLEX
1ig1	1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn.
1j1b	Binary complex structure of human tau protein kinase I with AMPPNP
1j1c	Binary complex structure of human tau protein kinase I with ADP
1j3h	Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit
1j91	Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the ATP-competitive inhibitor 4,5,6,7-tetrabromobenzotriazole
1jam	Crystal structure of apo-form of Z. Mays CK2 protein kinase alpha subunit
1jbp	Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Substrate Peptide, ADP and Detergent
1jkk	2.4A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MG.
1jkl	1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE
1jks	1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
1jkt	TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
1jlu	Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Phosphorylated Substrate Peptide and Detergent
1jnk	THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
1jow	Crystal structure of a complex of human CDK6 and a viral cyclin
1jst	PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A
1jsu	P27(KIP1)/CYCLIN A/CDK2 COMPLEX
1jsv	The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide
1jvp	Crystal structure of human CDK2 (unphosphorylated) in complex with PKF049-365
1jwh	Crystal Structure of Human Protein Kinase CK2 Holoenzyme
1ke5	CDK2 complexed with N-methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide
1ke6	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE
1ke7	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE
1ke8	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE
1ke9	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[4-({[AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE
1koa	TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS
1kob	TWITCHIN KINASE FRAGMENT (APLYSIA), AUTOREGULATED PROTEIN KINASE DOMAIN
1kv1	p38 MAP Kinase in Complex with Inhibitor 1
1kv2	Human p38 MAP Kinase in Complex with BIRB 796
1kwp	Crystal Structure of MAPKAP2
1l3r	Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase
1lew	CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A
1lez	CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B
1lp4	Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP
1lpu	Low Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
1lr4	Room Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
1m2p	Crystal structure of 1,8-di-hydroxy-4-nitro-anthraquinone/CK2 kinase complex
1m2q	Crystal structure of 1,8-di-hydroxy-4-nitro-xanten-9-one/CK2 kinase complex
1m2r	Crystal structure of 5,8-di-amino-1,4-di-hydroxy-anthraquinone/CK2 kinase complex
1m7q	Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor
1mq4	Crystal Structure of Aurora-A Protein Kinase
1mru	Intracellular Ser/Thr protein kinase domain of Mycobacterium tuberculosis PknB.
1mrv	crystal structure of an inactive Akt2 kinase domain
1mry	crystal structure of an inactive akt2 kinase domain
1muo	CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE
1na7	Crystal structure of the catalytic subunit of human protein kinase CK2
1nvq	The Complex Structure Of Checkpoint Kinase Chk1/UCN-01
1nvr	The Complex Structure Of Checkpoint Kinase Chk1/Staurosporine
1nvs	The Complex Structure Of Checkpoint Kinase Chk1/SB218078
1nxk	Crystal structure of staurosporine bound to MAP KAP kinase 2
1ny3	Crystal structure of ADP bound to MAP KAP kinase 2
1o6k	Structure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP
1o6l	Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with AMP-PNP and GSK3 peptide
1o6y	Catalytic domain of PknB kinase from Mycobacterium tuberculosis
1o9u	GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE
1ob3	Structure of P. falciparum PfPK5
1ogu	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR
1oi9	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
1oiq	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation
1oir	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation
1oit	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation
1oiu	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
1oiy	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
1okv	Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Ile-Phe-NH2
1okw	Cyclin A binding groove inhibitor Ac-Arg-Arg-Leu-Asn-(m-Cl-Phe)-NH2
1oky	Structure of human PDK1 kinase domain in complex with staurosporine
1okz	Structure of human PDK1 kinase domain in complex with UCN-01
1ol1	Cyclin A binding groove inhibitor H-Cit-Cit-Leu-Ile-(p-F-Phe)-NH2
1ol2	Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Asn-(p-F-Phe)-NH2
1ol5	Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43
1ol6	Structure of unphosphorylated D274N mutant of Aurora-A
1ol7	Structure of Human Aurora-A 122-403 phosphorylated on Thr287, Thr288
1om1	Crystal structure of maize CK2 alpha in complex with IQA
1omw	Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits
1ouk	The structure of p38 alpha in complex with a pyridinylimidazole inhibitor
1ouy	The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor
1ove	The structure of p38 alpha in complex with a dihydroquinolinone
1oz1	P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR
1p2a	The structure of cyclin dependent kinase 2 (CKD2) with a trisubstituted naphthostyril inhibitor
1p38	THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTOMS RESOLUTION
1p4f	DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT
1p5e	The strucure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)
1pf8	Crystal Structure of Human Cyclin-Dependent Kinase 2 Complexed with a Nucleoside Inhibitor
1phk	TWO STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHORYLASE, KINASE: AN ACTIVE PROTEIN KINASE COMPLEXED WITH NUCLEOTIDE, SUBSTRATE-ANALOGUE AND PRODUCT
1pjk	Crystal Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit
1pkd	THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO-CDK2/CYCLIN A
1pme	STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE
1pmn	Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
1pmu	The crystal structure of JNK3 in complex with a phenantroline inhibitor
1pmv	The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
1pw2	APO STRUCTURE OF HUMAN CYCLIN-DEPENDENT KINASE 2
1pxi	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,5-Dichloro-thiophen-3-yl)-pyrimidin-2-ylamine
1pxj	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine
1pxk	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-Dimethyl-thiazol-5-yl)pyrimidin-2-yl]-N'-hydroxyiminoformamide
1pxl	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-trifluoromethyl-phenyl)-amine
1pxm	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol
1pxn	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-[4-(4-Methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol
1pxo	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine
1pxp	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-N',N'-dimethyl-benzene-1,4-diamine
1pye	Crystal structure of CDK2 with inhibitor
1pyx	GSK-3 Beta complexed with AMP-PNP
1q24	PKA double mutant model of PKB in complex with MgATP
1q3d	GSK-3 Beta complexed with Staurosporine
1q3w	GSK-3 Beta complexed with Alsterpaullone
1q41	GSK-3 Beta complexed with Indirubin-3'-monoxime
1q4l	GSK-3 Beta complexed with Inhibitor I-5
1q5k	crystal structure of Glycogen synthase kinase 3 in complexed with inhibitor
1q61	PKA triple mutant model of PKB
1q62	PKA double mutant model of PKB
1q8t	The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632
1q8u	The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P
1q8w	The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077)
1q8y	The structure of the yeast SR protein kinase, Sky1p, with bound ADP
1q8z	The apoenzyme structure of the yeast SR protein kinase, Sky1p
1q97	The structure of the Saccharomyces cerevisiae SR protein kinase, Sky1p, with bound ATP
1q99	Crystal structure of the Saccharomyces cerevisiae SR protein kinsae, Sky1p, complexed with the non-hydrolyzable ATP analogue, AMP-PNP
1ql6	THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
1qmz	PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX
1r0e	Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor
1r39	THE STRUCTURE OF P38ALPHA
1r3c	THE STRUCTURE OF P38ALPHA C162S MUTANT
1r78	CDK2 complex with a 4-alkynyl oxindole inhibitor
1rdq	Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase
1re8	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2
1rej	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1
1rek	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8
1s9i	X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP
1s9j	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
1smh	Protein kinase A variant complex with completely ordered N-terminal helix
1stc	CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE
1sve	Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1
1svg	Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4
1svh	Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8
1syk	Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation
1szm	DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)
1tki	AUTOINHIBITED SERINE KINASE DOMAIN OF THE GIANT MUSCLE PROTEIN TITIN
1tvo	The structure of ERK2 in complex with a small molecule inhibitor
1u5q	Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
1u5r	Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
1ua2	Crystal Structure of Human CDK7
1ukh	Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
1uki	Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
1ung	Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.
1unh	Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.
1unl	Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin.
1urc	Cyclin A binding groove inhibitor Ace-Arg-Lys-Leu-Phe-Gly
1urw	CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-b]PYRIDAZINE
1uu3	Structure of human PDK1 kinase domain in complex with LY333531
1uu7	Structure of human PDK1 kinase domain in complex with BIM-2
1uu8	Structure of human PDK1 kinase domain in complex with BIM-1
1uu9	Structure of human PDK1 kinase domain in complex with BIM-3
1uv5	GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME
1uvr	Structure of human PDK1 kinase domain in complex with BIM-8
1v0b	Crystal structure of the t198a mutant of pfpk5
1v0o	Structure of P. falciparum PfPK5-Indirubin-5-sulphonate ligand complex
1v0p	Structure of P. falciparum PfPK5-Purvalanol B ligand complex
1v1k	CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR
1veb	Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 5
1vyw	Structure of CDK2/Cyclin A with PNU-292137
1vyz	Structure of CDK2 complexed with PNU-181227
1vzo	The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
1w0x	Crystal structure of human CDK2 in complex with the inhibitor olomoucine.
1w7h	p38 Kinase crystal structure in complex with small molecule inhibitor
1w82	p38 Kinase crystal structure in complex with small molecule inhibitor
1w83	p38 Kinase crystal structure in complex with small molecule inhibitor
1w84	p38 Kinase crystal structure in complex with small molecule inhibitor
1w8c	CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2
1w98	The structural basis of CDK2 activation by cyclin E
1wbn	fragment based p38 inhibitors
1wbo	fragment based p38 inhibitors
1wbs	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.
1wbt	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.
1wbv	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.
1wbw	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.
1wcc	screening for fragment binding by X-ray crystallography
1wfc	STRUCTURE OF APO, UNPHOSPHORYLATED, P38 MITOGEN ACTIVATED PROTEIN KINASE P38 (P38 MAP KINASE) THE MAMMALIAN HOMOLOGUE OF THE YEAST HOG1 PROTEIN
1wmk	Human death-associated kinase DRP-1, mutant S308D d40
1wvw	Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
1wvx	Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
1wvy	Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
1wzy	Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative
1xh4	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh5	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh6	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh7	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh8	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh9	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xha	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xjd	Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution
1xo2	Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin
1xqz	Crystal Structure of hPim-1 kinase at 2.1 A resolution
1xr1	Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution
1xws	Crystal Structure of the human PIM1 kinase domain
1y8g	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Inactive double mutant with selenomethionine
1y8y	Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor
1y91	Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor
1ydr	STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE
1yds	STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H8 PROTEIN KINASE INHIBITOR [N-(2-METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
1ydt	STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITOR N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE
1yhs	Crystal structure of Pim-1 bound to staurosporine
1yhv	Crystal Structure of PAK1 kinase domain with two point mutations (K299R, T423E)
1yhw	Crystal Structure of PAK1 kinase domain with one point mutations (K299R)
1yi3	Crystal Structure of Pim-1 bound to LY294002
1yi4	Structure of Pim-1 bound to adenosine
1ykr	Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor
1ym7	G Protein-Coupled Receptor Kinase 2 (GRK2)
1yqj	Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor
1yrp	Catalytic domain of human ZIP kinase phosphorylated at Thr265
1yw2	Mutated Mus Musculus P38 Kinase (mP38)
1ywr	Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor
1ywv	Crystal Structures of Proto-Oncogene Kinase Pim1: a Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma
1yxs	Crystal Structure of Kinase Pim1 with P123M mutation
1yxt	Crystal Structure of Kinase Pim1 in complex with AMPPNP
1yxu	Crystal Structure of Kinase Pim1 in Complex with AMP
1yxv	Crystal Structure of Kinase Pim1 in complex with 3,4-Dihydroxy-1-methylquinolin-2(1H)-one
1yxx	Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE
1z57	Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine
1z5m	Crystal Structure Of N1-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethylpropanediamide Complexed with Human PDK1
1z9x	Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 3 monomers in the asymmetric unit
1zlt	Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog
1zmu	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type
1zmv	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: K82R mutant
1zmw	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: T208A/S212A inactive double mutant
1zoe	Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors
1zog	Crystal structure of protein kinase CK2 in complex with TBB-derivatives
1zoh	Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors
1zrz	Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota
1zws	Crystal structure of the catalytic domain of human DRP-1 kinase
1zxe	Crystal Structure of eIF2alpha Protein Kinase GCN2: D835N Inactivating Mutant in Apo Form
1zy4	Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form.
1zy5	Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant Complexed with AMPPNP.
1zyc	Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type in Apo Form.
1zyd	Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type Complexed with ATP.
1zyj	Human P38 MAP Kinase in Complex with Inhibitor 1a
1zys	Co-crystal structure of Checkpoint Kinase Chk1 with a pyrrolo-pyridine inhibitor
1zz2	Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes
1zzl	Crystal structure of P38 with triazolopyridine
2a0c	Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
2a27	Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 8 monomers in the asymmetric unit
2a2a	High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase
2a4l	Human cyclin-dependent kinase 2 in complex with roscovitine
2ac3	Structure of human Mnk2 Kinase Domain
2ac5	Structure of human Mnk2 Kinase Domain mutant D228G
2acx	Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP
2ayp	Crystal Structure of CHK1 with an Indol Inhibitor
2b1p	inhibitor complex of JNK3
2b52	Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562
2b53	Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325
2b54	Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305
2b55	Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312
2b9f	Crystal structure of non-phosphorylated Fus3
2b9h	Crystal structure of Fus3 with a docking motif from Ste7
2b9i	Crystal structure of Fus3 with a docking motif from Msg5
2b9j	Crystal structure of Fus3 with a docking motif from Far1
2baj	p38alpha bound to pyrazolourea
2bak	p38alpha MAP kinase bound to MPAQ
2bal	p38alpha MAP kinase bound to pyrazoloamine
2baq	p38alpha bound to Ro3201195
2bcj	Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
2bdw	Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II
2bfx	Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
2bfy	complex of Aurora-B with INCENP and Hesperidin.
2bhe	HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 5-BROMO-INDIRUBINE
2bhh	HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 4-HYDROXYPIPERINDINESULFONYL-INDIRUBINE
2bik	Human Pim1 phosphorylated on Ser261
2bil	The human protein kinase Pim1 in complex with its consensus peptide Pimtide
2biy	Structure of PDK1-S241A mutant kinase domain
2bkz	STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611
2bmc	Aurora-2 T287D T288D complexed with PNU-680632
2bpm	STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529
2br1	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity
2brb	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity
2brg	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity
2brh	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity
2brm	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity
2brn	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity
2bro	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity
2btr	STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873
2bts	STRUCTURE OF CDK2 COMPLEXED WITH PNU-230032
2bva	Crystal structure of the human P21-activated kinase 4
2bzh	CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
2bzi	CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU2
2bzj	CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU3
2bzk	CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE
2c1a	Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino) ethyl)amide
2c1b	Structure of cAMP-dependent protein kinase complexed with (4R,2S)-5'-( 4-(4-Chlorobenzyloxy)pyrrolidin-2-ylmethanesulfonyl)isoquinoline
2c30	Crystal Structure Of The Human P21-Activated Kinase 6
2c3i	CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I
2c3j	Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification
2c3k	Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification
2c3l	Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification
2c4g	STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514
2c5n	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
2c5o	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
2c5v	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
2c5x	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
2c5y	DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN
2c68	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2c69	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2c6d	Aurora A kinase activated mutant (T287D) in complex with ADPNP
2c6e	Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor
2c6i	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2c6k	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2c6l	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2c6m	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2c6o	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2c6t	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2cch	The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
2cci	Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6
2cdz	CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4 IN COMPLEX WITH CGP74514A
2cgu	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening
2cgv	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening
2cgw	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening
2cgx	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening
2cjm	Mechanism of CDK inhibition by active site phosphorylation: CDK2 Y15p T160p in complex with cyclin A structure
2cke	Human death-associated DRP-1 kinase in complex with inhibitor
2clq	Structure of mitogen-activated protein kinase kinase kinase 5
2clx	4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects
2cn5	Crystal structure of human Chk2 in complex with ADP
2cn8	Crystal structure of human Chk2 in complex with debromohymenialdisine
2cpk	CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE
2ds1	Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor
2duv	Structure of CDK2 with a 3-hydroxychromones
2dwb	Aurora-A kinase complexed with AMPPNP
2dyl	Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)
2e9n	Structure of h-CHK1 complexed with A767085
2e9o	Structure of h-CHK1 complexed with AA582939
2e9p	Structure of h-CHK1 complexed with A771129
2e9u	Structure of h-CHK1 complexed with A780125
2e9v	Structure of h-CHK1 complexed with A859017
2erk	PHOSPHORYLATED MAP KINASE ERK2
2erz	Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil
2esm	Crystal Structure of ROCK 1 bound to fasudil
2etk	Crystal Structure of ROCK 1 bound to hydroxyfasudil
2etr	Crystal Structure of ROCK I bound to Y-27632
2eu9	Crystal Structure of CLK3
2euf	X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991
2ewa	Dual binding mode of pyridinylimidazole to MAP kinase p38
2exc	Inhibitor complex of JNK3
2exe	Crystal structure of the phosphorylated CLK3
2exm	Human CDK2 in complex with isopentenyladenine
2f2c	X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol
2f2u	crystal structure of the Rho-kinase kinase domain
2f49	Crystal structure of Fus3 in complex with a Ste5 peptide
2f57	Crystal Structure Of The Human P21-Activated Kinase 5
2f7e	PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine
2f7x	Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethyl]-ethylamine
2f7z	Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine
2f9g	Crystal structure of Fus3 phosphorylated on Tyr182
2fa2	Crystal structure of Fus3 without a peptide from Ste5
2fh9	Structure and dimerization of the kinase domain from yeast Snf1
2fsl	mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-A
2fsm	mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-B
2fso	mitogen activated protein kinase p38alpha (D176A) activating mutant
2fst	mitogen activated protein kinase p38alpha (D176A+F327L) activating mutant
2fum	Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone
2fvd	Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor
2fys	Crystal structure of Erk2 complex with KIM peptide derived from MKP3
2g01	Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
2g9x	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
2gcd	TAO2 kinase domain-staurosporine structure
2gdo	4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors
2gfc	cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24
2gfs	P38 Kinase Crystal Structure in complex with RO3201195
2ghg	h-CHK1 complexed with A431994
2ghl	Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743
2ghm	Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449
2gmx	Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity
2gnf	Protein kinase A fivefold mutant model of Rho-kinase with Y-27632
2gng	Protein kinase A fivefold mutant model of Rho-kinase
2gnh	PKA five fold mutant model of Rho-kinase with H1152P
2gni	PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077)
2gnj	PKA three fold mutant model of Rho-kinase with Y-27632
2gnl	PKA threefold mutant model of Rho-kinase with inhibitor H-1152P
2gph	Docking motif interactions in the MAP kinase ERK2
2gtm	Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579
2gtn	Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717
2gu8	Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies
2h6d	Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain)
2h96	Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
2h9v	Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632
2hak	Catalytic and ubiqutin-associated domains of MARK1/PAR-1
2hog	crystal structure of Chek1 in complex with inhibitor 20
2hw6	Crystal structure of Mnk1 catalytic domain
2hw7	Crystal Structure of Mnk2-D228G in complex with Staurosporine
2hxl	crystal structure of Chek1 in complex with inhibitor 1
2hxq	crystal structure of Chek1 in complex with inhibitor 2
2hy0	crystal structure of chek1 in complex with inhibitor 22
2hy8	PAK1 complex with ST2001
2i0e	Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor
2i0h	The structure of p38alpha in complex with an arylpyridazinone
2i40	Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor
2i6l	Crystal structure of human mitogen activated protein kinase 6 (MAPK6)
2iw6	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
2iw8	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR
2iw9	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
2iwi	CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
2j0i	CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4
2j2i	Crystal Structure of the humab PIM1 in complex with LY333531
2j4z	Structure of Aurora-2 in complex with PHA-680626
2j50	Structure of Aurora-2 in complex with PHA-739358
2j51	Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-( aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide
2j7t	Crystal structure of human serine threonine kinase-10 bound to SU11274
2j90	Crystal structure of human ZIP kinase in complex with a tetracyclic pyridone inhibitor (Pyridone 6)
2j9m	Crystal Structure of CDK2 in complex with Macrocyclic Aminopyrimidine
2jam	Crystal structure of human calmodulin-dependent protein kinase I G
2jav	Human Kinase with pyrrole-indolinone ligand
2jbo	Protein kinase MK2 in complex with an inhibitor (crystal form-1, soaking)
2jbp	Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization)
2jc6	Crystal structure of human calmodulin-dependent protein kinase 1D
2jd5	Sky1p bound to Npl3p-derived substrate peptide
2jdo	STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE
2jdr	STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654
2jds	Structure of cAMP-dependent protein kinase complexed with A-443654
2jdt	Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE
2jdv	Structure of PKA-PKB chimera complexed with A-443654
2jed	The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution.
2jfl	CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
2jfm	CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM)
2jgz	Crystal structure of phospho-CDK2 in complex with Cyclin B
2jld	Extremely Tight Binding of Ruthenium Complex to Glycogen Synthase Kinase 3
2lgc	Joint NMR and X-ray refinement reveals the structure of a novel dibenzo[a,d]cycloheptenone inhibitor/p38 MAP kinase complex in solution
2no3	Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
2np8	Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
2npq	A Novel Lipid Binding Site in the p38 alpha MAP Kinase
2o0u	Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide
2o2u	Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
2o3p	Crystal structure of Pim1 with Quercetin
2o5k	Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor
2o63	Crystal structure of Pim1 with Myricetin
2o64	Crystal structure of Pim1 with Quercetagetin
2o65	Crystal structure of Pim1 with Pentahydroxyflavone
2obj	Crystal structure of human PIM-1 Kinase in complex with inhibitor
2oh0	Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors
2oi4	Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole
2ojf	Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors
2ojg	Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2oji	Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2ojj	Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2ok1	Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2okr	Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer
2onl	Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer
2ou7	Structure of the Catalytic Domain of Human Polo-like Kinase 1
2ow3	Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor
2owb	Structure of the Catalytic Domain of Human Polo-like Kinase 1
2oxd	Protein kinase CK2 in complex with tetrabromobenzoimidazole K17, K22 and K32 inhibitors
2oxx	Protein kinase CK2 in complex with tetrabromobenzoimidazole derivatives K17, K22 and K32
2oxy	Protein kinase CK2 in complex with tetrabromobenzoimidazole derivatives K17, K22 and K32
2oza	Structure of p38alpha complex
2p33	Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors
2p3g	Crystal structure of a pyrrolopyridine inhibitor bound to MAPKAP Kinase-2
2p55	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
2pe0	CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX
2pe1	CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) {2-Oxo-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-2,3-dihydro-1H-indol-5-yl}-urea {BX-517} COMPLEX
2pe2	CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 3-{5-[2-Oxo-5-ureido-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrol-3-yl}-N-(2-piperidin-1-yl-ethyl)-benzamide COMPLEX
2phk	THE CRYSTAL STRUCTURE OF A PHOSPHORYLASE KINASE PEPTIDE SUBSTRATE COMPLEX: KINASE SUBSTRATE RECOGNITION
2pk9	Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway
2pmi	Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S
2puu	Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea
2pvh	Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2
2pvj	Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2
2pvk	Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2
2pvl	Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2
2pvm	Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2
2pvn	Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2
2pvr	Crystal structure of the catalytic subunit of protein kinase CK2 (C-terminal deletion mutant 1-335) in complex with two sulfate ions
2pzy	Structure of MK2 Complexed with Compound 76
2q0n	Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide
2qc6	Protein kinase CK2 in complex with DBC
2qcs	A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state
2qd9	P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds
2qg5	Cryptosporidium parvum calcium dependent protein kinase cgd7_1840
2qhm	crystal structure of Chek1 in complex with inhibitor 2a
2qhn	Crystal Structure of Chek1 in Complex with Inhibitor 1a
2qkr	Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with indirubin 3'-monoxime bound
2qnj	Kinase and Ubiquitin-associated domains of MARK3/Par-1
2qr7	2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative
2qr8	2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)
2qur	Crystal Structure of F327A/K285P Mutant of cAMP-dependent Protein Kinase
2qvs	Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase
2r0i	Crystal structure of a kinase MARK2/Par-1 mutant
2r0u	Crystal Structure of Chek1 in Complex with Inhibitor 54
2r3f	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3g	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3h	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3i	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3j	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3k	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3l	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3m	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3n	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3o	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3p	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3q	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r3r	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
2r5t	Crystal Structure of Inactive Serum and Glucocorticoid- Regulated Kinase 1 in Complex with AMP-PNP
2r64	Crystal structure of a 3-aminoindazole compound with CDK2
2r7b	Crystal Structure of the Phosphoinositide-dependent Kinase-1 (PDK-1)Catalytic Domain bound to a dibenzonaphthyridine inhibitor
2r7i	Crystal structure of catalytic subunit of protein kinase CK2
2r9s	c-Jun N-terminal Kinase 3 with 3,5-Disubstituted Quinoline inhibitor
2rg5	Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B
2rg6	Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J
2rku	Structure of PLK1 in complex with BI2536
2uue	REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
2uv2	Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5- Cyclopropyl-1H-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile
2uvx	Structure of PKA-PKB chimera complexed with 7-azaindole
2uvy	Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine
2uvz	Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine
2uw0	Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl) -piperidin-4-yl)-phenyl)-9H-purine
2uw3	Structure of PKA-PKB chimera complexed with 5-methyl-4-phenyl-1H- pyrazole
2uw4	Structure of PKA-PKB chimera complexed with 2-(4-(5-methyl-1H-pyrazol- 4-yl)-phenyl)-ethylamine
2uw5	Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine
2uw6	Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine
2uw7	Structure of PKA-PKB chimera complexed with 4-(4-chloro-phenyl)-4-(4- (1H-pyrazol-4-yl)-phenyl)-piperidine
2uw8	Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine
2uw9	STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-( 1H-pyrazol-4-yl)-phenyl)-piperidine
2uzb	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uzd	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uze	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uzl	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uzn	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uzo	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uzt	PKA structures of AKT, indazole-pyridine inhibitors
2uzu	PKA structures of indazole-pyridine series of AKT inhibitors
2uzv	PKA structures of indazole-pyridine series of AKT inhibitors
2uzw	PKA structures of indazole-pyridine series of AKT inhibitors
2v0d	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2v22	REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
2v55	Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
2v5q	CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN
2v7o	Crystal structure of human calcium-calmodulin-dependent protein kinase II gamma
2vag	Crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor
2vd5	Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII
2vgo	Crystal structure of Aurora B kinase in complex with Reversine inhibitor
2vgp	Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor
2vn9	Crystal Structure of Human Calcium Calmodulin dependent Protein Kinase II delta isoform 1, CAMKD
2vnw	Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)methanamine
2vny	Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)amine
2vo0	Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-( 7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine
2vo3	Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorobenzyl)-1-( 7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine
2vo6	Structure of PKA-PKB chimera complexed with 4-(4-Chlorobenzyl)-1-(7H- pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-ylamine
2vo7	Structure of PKA complexed with 4-(4-Chlorobenzyl)-1-(7H-pyrrolo(2,3- d)pyrimidin-4-yl)piperidin-4-ylamine
2vrx	Structure of Aurora B kinase in complex with ZM447439
2vta	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vth	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vti	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vtj	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vtl	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vtm	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vtn	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vto	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vtp	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vtq	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vtr	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vts	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vtt	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vu3	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
2vv9	CDK2 in complex with an imidazole piperazine
2vwi	Structure of the OSR1 kinase, a hypertension drug target
2vx3	Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A
2vz6	Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804
2w05	Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5b
2w06	Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5c
2w0j	Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor
2w17	CDK2 in complex with the imidazole pyrimidine amide, compound (S)-8b
2w1c	Structure determination of Aurora Kinase in complex with inhibitor
2w1d	Structure determination of Aurora Kinase in complex with inhibitor
2w1e	Structure determination of Aurora Kinase in complex with inhibitor
2w1f	Structure determination of Aurora Kinase in complex with inhibitor
2w1g	Structure determination of Aurora Kinase in complex with inhibitor
2w1h	Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi- targeted Kinase Inhibitor with Potent Aurora Kinase Activity
2w4j	X-ray structure of a DAP-Kinase 2-277
2w4k	X-ray structure of a DAP-Kinase 2-302
2w4o	Crystal structure of Human CAMK4 in complex with 4-Amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)
2w5a	Human Nek2 kinase ADP-bound
2w5b	Human Nek2 kinase ATPgammaS-bound
2w5h	Human Nek2 kinase ATPgammaS-bound
2w7x	Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019
2w96	Crystal Structure of CDK4 in complex with a D-type cyclin
2w99	Crystal Structure of CDK4 in complex with a D-type cyclin
2w9f	Crystal Structure of CDK4 in complex with a D-type cyclin
2w9z	Crystal Structure of CDK4 in complex with a D-type cyclin
2waj	Crystal structure of human Jnk3 complexed with a 1-aryl-3,4- dihydroisoquinoline inhibitor
2wei	Crystal structure of the kinase domain of Cryptosporidium parvum calcium dependent protein kinase in complex with 3-MB-PP1
2wel	Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin
2wev	Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
2wfy	Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
2whb	Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
2wih	STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125
2wip	STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID
2wma	Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
2wmb	Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
2wmq	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2wmr	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2wms	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2wmt	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2wmu	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2wmv	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2wmw	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2wmx	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2wnt	Crystal Structure of the Human Ribosomal protein S6 kinase
2wo6	Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide
2wpa	Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing
2wqe	Structure of S155R Aurora-A somatic mutant
2wqm	Structure of apo human Nek7
2wqn	Structure of ADP-bound human Nek7
2wqo	STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950
2wtc	CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
2wtd	Crystal structure of Chk2 in complex with an inhibitor
2wti	CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
2wtj	CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
2wtk	Structure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
2wtv	Aurora-A Inhibitor Structure
2wtw	Aurora-A Inhibitor Structure (2nd crystal form)
2wu6	Crystal Structure of the Human CLK3 in complex with DKI
2wu7	Crystal Structure of the Human CLK3 in complex with V25
2wxv	Structure of CDK2-CYCLIN A with a Pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor
2wzj	Catalytic and UBA domain of kinase MARK2/(Par-1) K82R, T208E double mutant
2x0g	X-RAY STRUCTURE OF A DAP-KINASE CALMODULIN COMPLEX
2x1n	Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
2x39	Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin- 4-yl)piperidine-4-carboxamide bound to PKB
2x4f	The Crystal Structure of the human myosin light chain kinase LOC340156.
2x4z	Crystal Structure of the Human p21-Activated Kinase 4 in Complex with PF-03758309
2x6d	Aurora-A bound to an inhibitor
2x6e	Aurora-A bound to an inhibitor
2x7f	Crystal structure of the kinase domain of human Traf2- and Nck- interacting Kinase with Wee1Chk1 inhibitor
2x81	STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054
2x8d	Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration
2x8e	Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration
2x8i	Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration
2x9e	HUMAN MPS1 IN COMPLEX WITH NMS-P715
2xbj	Crystal Structure of Chk2 in complex with an inhibitor
2xch	Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor
2xck	Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor
2xey	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2xez	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2xf0	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2xh5	Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB
2xik	Structure of Human YSK1 (Yeast Sps1-Ste20-related Kinase 1)
2xix	Protein kinase Pim-1 in complex with fragment-1 from crystallographic fragment screen
2xiy	Protein kinase Pim-1 in complex with fragment-2 from crystallographic fragment screen
2xiz	Protein kinase Pim-1 in complex with fragment-3 from crystallographic fragment screen
2xj0	Protein kinase Pim-1 in complex with fragment-4 from crystallographic fragment screen
2xj1	Protein kinase Pim-1 in complex with small molecule inibitor
2xj2	Protein kinase Pim-1 in complex with small molecule inhibitor
2xk3	Structure of Nek2 bound to Aminopyrazine compound 35
2xk4	Structure of Nek2 bound to aminopyrazine compound 17
2xk6	Structure of Nek2 bound to aminopyrazine compound 36
2xk7	Structure of Nek2 bound to aminopyrazine compound 23
2xk8	Structure of Nek2 bound to aminopyrazine compound 15
2xk9	Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533
2xkc	Structure of Nek2 bound to aminopyrazine compound 14
2xkd	Structure of Nek2 bound to aminopyrazine compound 12
2xke	Structure of Nek2 bound to Aminipyrazine Compound 5
2xkf	Structure of Nek2 bound to aminopyrazine compound 2
2xm8	Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2
2xm9	Structure of a small molecule inhibitor with the kinase domain of Chk2
2xmy	Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents
2xnb	Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents
2xne	Structure of Aurora-A bound to an imidazopyrazine inhibitor
2xng	Structure of Aurora-A bound to a selective imidazopyrazine inhibitor
2xnm	Structure of NEK2 bound to CCT
2xnn	Structure of Nek2 bound to CCT242430
2xno	Structure of Nek2 bound to CCT243779
2xnp	Structure of Nek2 bound to CCT244858
2xru	AURORA-A T288E COMPLEXED WITH PHA-828300
2xrw	Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
2xs0	Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
2xuu	Crystal structure of a DAP-kinase 1 mutant
2xzs	Death associated protein kinase 1 residues 1-312
2y0a	Structure of DAPK1 construct residues 1-304
2y4i	KSR2-MEK1 heterodimer
2y4p	Dimeric structure of DAPK-1 catalytic domain
2y7j	Structure of human phosphorylase kinase, gamma 2
2y8o	Crystal structure of human p38alpha complexed with a MAPK docking peptide
2y9q	Crystal structure of human ERK2 complexed with a MAPK docking peptide
2ya9	Crystal structure of the autoinhibited form of mouse DAPK2
2yaa	Crystal structure of the autoinhibited form of mouse DAPK2 in complex with ATP
2yab	Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP
2yac	Crystal structure of Polo-like kinase 1 in complex with NMS-P937
2yak	Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV)
2ycf	Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531
2ycq	Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115
2ycr	Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976
2ycs	Crystal structure of checkpoint kinase 2 in complex with PV788
2ydi	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas
2ydj	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas
2ydk	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas
2yer	Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
2yex	Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
2yiq	Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322
2yir	Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352
2yis	triazolopyridine inhibitors of p38 kinase.
2yit	Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor
2yiw	triazolopyridine inhibitors of p38 kinase
2yix	Triazolopyridine Inhibitors of p38
2ym3	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2ym4	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2ym5	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2ym6	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2ym7	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2ym8	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
2ywp	Crystal Structure of CHK1 with a Urea Inhibitor
2yza	Crystal structure of kinase domain of Human 5'-AMP-activated protein kinase alpha-2 subunit mutant (T172D)
2z7l	Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid
2z7q	Crystal structure of the N-terminal kinase domain of human RSK-1 bound to AMP-PCP
2z7r	Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine
2z7s	Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A
2zaz	Crystal structure of P38 in complex with 4-anilino quinoline inhibitor
2zb0	Crystal structure of P38 in complex with biphenyl amide inhibitor
2zb1	Crystal structure of P38 in complex with biphenyl amide inhibitor
2zdt	Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor
2zdu	Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor
2zjw	Crystal structure of human CK2 alpha complexed with Ellagic acid
2zmc	Crystal structure of human mitotic checkpoint kinase Mps1 catalytic domain apo form
2zmd	Crystal structure of human Mps1 catalytic domain T686A mutant in complex with SP600125 inhibitor
2zoq	Structural dissection of human mitogen-activated kinase ERK1
2zv2	Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609
3a2c	Crystal structure of a pyrazolopyrimidine inhibitor complex bound to MAPKAP Kinase-2 (MK2)
3a60	Crystal structure of unphosphorylated p70S6K1 (Form I)
3a61	Crystal structure of unphosphorylated p70S6K1 (Form II)
3a62	Crystal structure of phosphorylated p70S6K1
3a7f	Human MST3 kinase
3a7g	Human MST3 kinase
3a7h	Human MST3 kinase in complex with ATP
3a7i	Human MST3 kinase in complex with adenine
3a7j	Human MST3 kinase in complex with MnADP
3a8w	Crystal Structure of PKCiota kinase domain
3a8x	Crystal Structure of PKCiota kinase domain
3a99	Structure of PIM-1 kinase crystallized in the presence of P27KIP1 Carboxy-terminal peptide
3ag9	Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1012
3agl	Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1039
3agm	Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670
3aln	Crystal Structure of human non-phosphorylated MKK4 kinase domain complexed with AMP-PNP
3alo	Crystal structure of human non-phosphorylated MKK4 kinase domain ternary complex with AMP-PNP and p38 peptide
3ama	Protein kinase A sixfold mutant model of Aurora B with inhibitor JNJ-7706621
3amb	Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680
3amy	Crystal structure of human CK2 alpha complexed with apigenin
3anq	human DYRK1A/inhibitor complex
3anr	human DYRK1A/harmine complex
3aqv	Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C
3at2	Crystal structure of CK2alpha
3at3	Crystal structure of CK2alpha with pyradine derivative
3at4	Crystal structure of CK2alpha with pyradine derivertive
3axw	Crystal structure of human CK2alpha complexed with a potent inhibitor
3be9	Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities
3bgp	Human Pim-1 complexed with a benzoisoxazole inhibitor VX1
3bgq	Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2
3bgz	Human Pim-1 kinase in complex with diphenyl indole inhibitor VX3
3bhh	Crystal structure of human calcium/calmodulin-dependent protein kinase IIB isoform 1 (CAMK2B)
3bht	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3
3bhu	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5
3bhv	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B
3bhy	Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with a beta-carboline ligand
3blh	Crystal Structure of Human CDK9/cyclinT1
3blq	Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP
3blr	Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol
3bqc	High pH-value crystal structure of emodin in complex with the catalytic subunit of protein kinase CK2
3bqr	Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with an imidazo-pyridazine ligand
3bv2	Morpholino pyrrolotriazine P38 Alpha map kinase inhibitor compound 30
3bv3	Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2
3bwf	Crystal structure of the human Pim1 in complex with an osmium compound
3bwj	Complex of PKA with the bisubstrate protein kinase inhibitor lead compound Arc-1034
3bx5	P38 alpha map kinase complexed with BMS-640994
3c0g	CASK CaM-Kinase Domain- 3'-AMP complex, P1 form
3c0h	CASK CaM-Kinase Domain- AMPPNP complex, P1 form
3c0i	CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form
3c13	Low pH-value crystal structure of emodin in complex with the catalytic subunit of protein kinase CK2
3c4e	Pim-1 Kinase Domain in Complex with 3-aminophenyl-7-azaindole
3c4w	Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A
3c4x	Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A
3c4y	Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A
3c4z	Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A
3c50	Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A
3c51	Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A
3c5u	P38 ALPHA map kinase complexed with a benzothiazole based inhibitor
3c9w	Crystal Structure of ERK-2 with hypothemycin covalently bound
3cek	Crystal structure of human dual specificity protein kinase (TTK)
3cgf	IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding
3cgo	IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding
3cik	Human GRK2 in Complex with Gbetagamma subunits
3ckw	Crystal structure of sterile 20-like kinase 3 (MST3, STK24)
3ckx	Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine
3coh	Crystal structure of Aurora-A in complex with a pentacyclic inhibitor
3coi	Crystal structure of p38delta kinase
3cok	Crystal structure of PLK4 kinase
3com	Crystal structure of Mst1 kinase
3cqu	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
3cqw	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
3ctq	Structure of MAP kinase p38 in complex with a 1-o-tolyl-1,2,3-triazole-4-carboxamide
3cxw	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand I
3cy2	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand II
3cy3	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V
3d0e	Crystal structure of human Akt2 in complex with GSK690693
3d14	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea
3d15	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-(3-chloro-phenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)- ethyl]-thiazol-2-yl}-urea [SNS-314]
3d2i	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylamino)-ethyl]-thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea
3d2k	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with [7-(2-{2-[3-(3-chloro-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid
3d5u	Crystal structure of a wildtype Polo-like kinase 1 (Plk1) catalytic domain.
3d5v	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain.
3d5w	Crystal structure of a phosphorylated Polo-like kinase 1 (Plk1) catalytic domain in complex with ADP.
3d5x	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with wortmannin.
3d7z	Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor
3d83	Crystal structure of P38 kinase in complex with a biphenyl amide inhibitor
3d9v	CRYSTAL STRUCTURE OF ROCK I BOUND TO H-1152P A DI-METHYLATED VARIANT OF FASUDIL
3da6	Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine
3dae	Crystal structure of phosphorylated SNF1 kinase domain
3daj	Crystal structure of Aurora A complexed with an inhibitor discovered through site-directed dynamic tethering
3dak	Crystal Structure of Domain-Swapped OSR1 kinase domain
3db6	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902
3db8	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 041
3dbc	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 257
3dbd	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094
3dbe	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 557
3dbf	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 562
3dbq	Crystal structure of TTK kinase domain
3dcv	Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one
3ddp	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8
3ddq	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
3dfa	Crystal structure of kinase domain of calcium-dependent protein kinase cgd3_920 from Cryptosporidium parvum
3dfc	Crystal structure of a glycine-rich loop mutant of the death associated protein kinase catalytic domain with AMPPNP
3dgk	Crystal structure of a glycine-rich loop mutant of the death associated protein kinase catalytic domain
3dj5	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.
3dj6	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 823.
3dj7	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 130.
3dls	Crystal structure of human PAS kinase bound to ADP
3dnd	cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24
3dne	cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24
3dog	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1
3ds6	P38 complex with a phthalazine inhibitor
3dt1	P38 Complexed with a quinazoline inhibitor
3du8	Crystal structure of GSK-3 beta in complex with NMS-869553A
3dv3	MEK1 with PF-04622664 Bound
3dxn	Crystal structure of the calcium-dependent kinase from toxoplasma gondii, 541.m00134, kinase domain.
3dy7	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
3e3b	Crystal structure of catalytic subunit of human protein kinase CK2alpha prime with a potent indazole-derivative inhibitor
3e3p	Glycogen synthase kinase from Leishmania major
3e5a	Crystal structure of Aurora A in complex with VX-680 and TPX2
3e7o	Crystal Structure of JNK2
3e87	Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
3e88	Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
3e8c	Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors
3e8d	Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
3e8e	Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors
3e8n	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP
3e92	Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor
3e93	Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor
3eb0	Crystal Structure of cgd4_240 from cryptosporidium Parvum in complex with indirubin E804
3efw	Structure of AuroraA with pyridyl-pyrimidine urea inhibitor
3eh9	Crystal structure of death associated protein kinase complexed with ADP
3eha	Crystal structure of death associated protein kinase complexed with AMPPNP
3eid	CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
3ej1	CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
3elj	Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor.
3enm	The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
3eoc	Cdk2/CyclinA complexed with a imidazo triazin-2-amine
3eqb	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
3eqc	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P
3eqd	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P
3eqf	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P
3eqg	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with PD, ADP AND MG2P
3eqh	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with U0126, ADP and MG2P
3eqi	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ADP and MG2P
3erk	THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025
3ezr	CDK-2 with indazole inhibitor 17 bound at its active site
3ezv	CDK-2 with indazole inhibitor 9 bound at its active site
3f2a	Crystal structure of human Pim-1 in complex with DAPPA
3f3z	Crystal structure of Cryptosporidium parvum calcium dependent protein kinase cgd7_1840 in presence of indirubin E804
3f5g	Crystal structure of death associated protein kinase in complex with ADP and Mg2+
3f5u	Crystal structure of the death associated protein kinase in complex with AMPPNP and Mg2+
3f5x	CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site
3f61	Crystal Structure of M. tuberculosis PknB Leu33Asp/Val222Asp double mutant in complex with ADP
3f69	Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720
3f7z	X-ray Co-Crystal Structure of Glycogen Synthase Kinase 3beta in Complex with an Inhibitor
3f88	glycogen synthase Kinase 3beta inhibitor complex
3f9n	Crystal structure of chk1 kinase in complex with inhibitor 38
3fc1	Crystal structure of p38 kinase bound to pyrimido-pyridazinone inhibitor
3fc2	PLK1 in complex with BI6727
3fdn	Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity
3fe3	Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant
3fhi	Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA
3fhr	High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3 (MK3)-inhibitor complex
3fi2	Crystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451
3fi3	Crystal structure of JNK3 with indazole inhibitor, SR-3737
3fi4	P38 kinase crystal structure in complex with RO4499
3fjq	Crystal structure of cAMP-dependent protein kinase catalytic subunit alpha in complex with peptide inhibitor PKI alpha (6-25)
3fkl	P38 kinase crystal structure in complex with RO9552
3fkn	P38 kinase crystal structure in complex with RO7125
3fko	P38 kinase crystal structure in complex with RO3668
3fl4	P38 kinase crystal structure in complex with RO5634
3fl5	Protein kinase CK2 in complex with the inhibitor Quinalizarin
3fln	P38 kinase crystal structure in complex with R1487
3flq	P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin
3fls	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-2-((R)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
3flw	P38 kinase crystal structure in complex with pamapimod
3fly	P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-isopropylamino-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one
3flz	P38 kinase crystal structure in complex WITH 8-Methyl-6-phenoxy-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
3fme	Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D)
3fmh	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((R)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
3fmj	P38 kinase crystal structure in complex with 4-(5-Methyl-3-phenyl-isoxazol-4-yl)-pyrimidin-2-ylamine
3fmk	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((S)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
3fml	P38 kinase crystal structure in complex with RO6224
3fmm	P38 kinase crystal structure in complex with RO6226
3fmn	P38 kinase crystal structure in complex with RO2530
3fpm	Crystal Structure of a Squarate Inhibitor bound to MAPKAP Kinase-2
3fsf	P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
3fsk	P38 kinase crystal structure in complex with RO6257
3fv8	JNK3 bound to piperazine amide inhibitor, SR2774.
3fwq	Inactive conformation of human protein kinase CK2 catalytic subunit
3fxw	High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3/inhibitor 2 complex
3fxz	Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172
3fy0	Crystal structure of PAK1 kinase domain with ruthenium complex DW1
3fyj	Crystal structure of an optimzied benzothiophene inhibitor bound to MAPKAP Kinase-2 (MK-2)
3fyk	Crystal structure of a benzthiophene lead bound to MAPKAP Kinase-2 (MK-2)
3fz1	Crystal structure of a benzthiophene inhibitor bound to human Cyclin-dependent Kinase-2 (CDK-2)
3g33	Crystal structure of CDK4/cyclin D3
3g51	Structural diversity of the active conformation of the N-terminal kinase domain of p90 ribosomal S6 kinase 2
3g90	JNK-3 bound to (Z)-5-fluoro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one
3g9l	JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-styrylindolin-2-one
3g9n	JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-phenylindolin-2-one
3gb2	GSK3beta inhibitor complex
3gbz	Structure of the CMGC CDK Kinase from Giardia lamblia
3gc0	Structure of the CMGC CDK Kinase from Giardia lamblia in complex with AMP
3gc7	The structure of p38alpha in complex with a dihydroquinazolinone
3gc8	The structure of p38beta C162S in complex with a dihydroquinazolinone
3gc9	The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor
3gcp	Human P38 MAP Kinase in Complex with SB203580
3gcq	Human P38 MAP kinase in complex with RL45
3gcs	Human P38 MAP kinase in complex with Sorafenib
3gcu	Human P38 MAP kinase in complex with RL48
3gcv	Human P38 MAP Kinase in Complex with RL62
3gfe	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor
3gfw	Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrolo-pyridin ligand
3ggf	Crystal structure of human Serine/threonine-protein kinase MST4 in complex with an quinazolin
3gi3	Crystal structure of a N-Phenyl-N'-Naphthylurea analog in complex with p38 MAP kinase
3gok	Binding site mapping of protein ligands
3gp0	Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib
3gu4	Crystal structure of DAPKQ23V-AMPPNP
3gu5	Crystal structure of DAPKQ23V-AMPPNP-Mg2+
3gu6	Crystal structure of DAPKQ23V-ADP
3gu7	Crystal structure of DAPKQ23V-ADP-Mg2+
3gu8	Crystal structure of DAPKL93G with N6-cyclopentyladenosine
3gub	Crystal structure of DAPKL93G complexed with N6-(2-Phenylethyl)adenosine
3h0y	Aurora A in complex with a bisanilinopyrimidine
3h0z	Aurora A in complex with a bisanilinopyrimidine
3h10	Aurora A inhibitor complex
3h30	Crystal structure of the catalytic subunit of human protein kinase CK2 with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole
3h4j	crystal structure of pombe AMPK KDAID fragment
3h9f	Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand
3h9o	Phosphoinositide-dependent protein kinase 1 (PDK-1) in complex with compound 9
3ha6	Crystal structure of aurora A in complex with TPX2 and compound 10
3ha8	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/Compound 14b
3hdm	Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 1
3hdn	Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 2
3hec	P38 in complex with Imatinib
3heg	P38 in complex with Sorafenib
3hko	Crystal structure of a cdpk kinase domain from cryptosporidium Parvum, cgd7_40
3hl7	Crystal Structure of Human p38alpha complexed with SD-0006
3hll	Crystal Structure of Human p38alpha complexed with PH-797804
3hmn	Crystal structure of human Mps1 catalytic domain in complex with ATP
3hmo	Crystal structure of human Mps1 catalytic domain in complex with the inhibitor staurosporine
3hmp	Crystal structure of human Mps1 catalytic domain in complex with a quinazolin ligand Compound 4
3hp2	Crystal Structure of Human p38alpha complexed with a pyridinone compound
3hp5	Crystal Structure of Human p38alpha complexed with a pyrimidopyridazinone compound
3hrb	p38 kinase Crystal structure in complex with small molecule inhibitor
3hrc	Crystal structure of a mutant of human PDK1 Kinase domain in complex with ATP
3hrf	Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket
3hub	Human p38 MAP Kinase in Complex with Scios-469
3huc	Human p38 MAP Kinase in Complex with RL40
3hv3	Human p38 MAP Kinase in Complex with RL49
3hv4	Human p38 MAP Kinase in Complex with RL51
3hv5	Human p38 MAP Kinase in Complex with RL24
3hv6	Human p38 MAP Kinase in Complex with RL39
3hv7	Human p38 MAP Kinase in Complex with RL38
3hvc	Crystal structure of human p38alpha MAP kinase
3hx4	Crystal structure of CDPK1 of Toxoplasma gondii, TGME49_101440, in presence of calcium
3hyh	Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1
3hzt	Crystal structure of Toxoplasma gondii CDPK3, TGME49_105860
3i4b	Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor
3i5z	Crystal structure of ERK2 bound to (S)-N-(2-hydroxy-1-phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimidin-4-yl)-1H-pyrrole-2-carboxamide
3i60	Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5-methylpyrimidin-4-yl)-N-(2-hydroxy-1-phenylethyl)-1H-pyrrole-2-carboxamide
3i6u	Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase
3i6w	Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase
3i79	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1)
3i7b	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NM-PP1
3i7c	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NA-PP2
3idb	Crystal structure of (108-268)RIIb:C holoenzyme of cAMP-dependent protein kinase
3idc	Crystal structure of (102-265)RIIb:C holoenzyme of cAMP-dependent protein kinase
3iec	Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates
3ig7	Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2
3igg	Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2
3igo	Crystal structure of Cryptosporidium parvum CDPK1, cgd3_920
3ion	PDK1 in complex with Compound 8h
3iop	PDK-1 in complex with the inhibitor Compound-8i
3iph	Crystal structure of p38 in complex with a biphenylamide inhibitor
3is5	Crystal structure of CDPK kinase domain from toxoplasma Gondii, TGME49_018720
3itz	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor
3iw4	Crystal structure of PKC alpha in complex with NVP-AEB071
3iw5	Human p38 MAP Kinase in Complex with an Indole Derivative
3iw6	Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol
3iw7	Human p38 MAP Kinase in Complex with an Imidazo-pyridine
3iw8	Structure of Inactive Human p38 MAP Kinase in Complex with a Thiazole-Urea
3j4q	Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from electron microscopy
3j4r	Pseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopy
3jpv	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a pyrrolo[2,3-a]carbazole ligand
3juh	Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity
3jvr	Characterization of the Chk1 allosteric inhibitor binding site
3jvs	Characterization of the Chk1 allosteric inhibitor binding site
3jxw	Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
3jy0	Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
3jya	Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
3k2l	Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2)
3k3i	p38alpha bound to novel DGF-out compound PF-00215955
3k3j	P38alpha bound to novel DFG-out compound PF-00416121
3k5u	Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor
3ka0	MK2 complex with inhibitor 6-(5-(2-aminopyrimidin-4-ylamino)-2-hydroxyphenyl)-N-methylbenzo[b]thiophene-2-carboxamide
3kb7	Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor
3kc3	MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine
3kf7	Crystal Structure of Human p38alpha Complexed With a Triazolopyrimidine compound
3kga	Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor
3kk8	CaMKII Substrate Complex A
3kk9	CaMKII Substrate Complex B
3kkv	Structure of PKA with a protein Kinase B-selective inhibitor.
3kl8	CaMKIINtide Inhibitor Complex
3kn5	Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP
3kn6	Crystal structure of the C-terminal kinase domain of MSK1
3kq7	Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide
3krw	Human GRK2 in complex with Gbetgamma subunits and balanol (soak)
3krx	Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)
3ku2	Crystal Structure of inactivated form of CDPK1 from toxoplasma gondii, TGME49.101440
3kvw	Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand
3kvx	JNK3 bound to aminopyrimidine inhibitor, SR-3562
3kxg	Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor 3,4,5,6,7-pentabromo-1H-indazole (K64)
3kxh	Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor (2-dymethylammino-4,5,6,7-tetrabromobenzoimidazol-1yl-acetic acid (K66)
3kxm	Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor K74
3kxn	Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor tetraiodobenzimidazole (K88)
3l1s	3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3
3l8s	Human p38 MAP Kinase in Complex with CP-547632
3l8x	P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor
3l9l	Crystal structure of pka with compound 36
3l9m	Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18
3l9n	crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27
3lau	Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor
3le6	The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor
3lfa	Human p38 MAP Kinase in Complex with Dasatinib
3lfb	Human p38 MAP Kinase in Complex with RL98
3lfc	Human p38 MAP Kinase in Complex with RL99
3lfd	Human p38 MAP Kinase in Complex with RL113
3lfe	Human p38 MAP Kinase in Complex with RL116
3lff	Human p38 MAP Kinase in Complex with RL166
3lfn	Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor
3lfq	Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor
3lfs	Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor
3lhj	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor.
3lij	Crystal structure of full length CpCDPK3 (cgd5_820) in complex with Ca2+ and AMPPNP
3llt	Crystal structure of PF14_0431, kinase domain.
3lm0	Crystal Structure of human Serine/Threonine Kinase 17B (STK17B)
3lm5	Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin
3lq5	Structure of CDK9/CyclinT in complex with S-CR8
3m11	Crystal Structure of Aurora A Kinase complexed with inhibitor
3m1s	Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3
3m2w	Crystal structure of MAPKAK kinase 2 (MK2) complexed with a spiroazetidine-tetracyclic ATP site inhibitor
3m42	Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor
3ma3	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand
3ma6	Crystal structure of kinase domain of TgCDPK1 in presence of 3BrB-PP1
3mb6	Human CK2 catalytic domain in complex with a difurane derivative inhibitor (CPA)
3mb7	Human CK2 catalytic domain in complex with a difurane derivative inhibitor (AMR)
3mbl	Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP
3mfr	CASK-4M CaM Kinase Domain, native
3mfs	CASK-4M CaM Kinase Domain, AMPPNP
3mft	CASK-4M CaM Kinase Domain, Mn2+
3mfu	CASK-4M CaM Kinase Domain, AMPPNP-Mn2+
3mgy	Mutagenesis of p38 MAP Kinase eshtablishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state
3mh0	Mutagenesis of p38 MAP Kinase eshtablishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state
3mh1	Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state
3mh2	Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state
3mh3	Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state
3mi9	Crystal structure of HIV-1 Tat complexed with human P-TEFb
3mia	Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb
3mn3	An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1
3mpa	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding
3mpt	Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor
3mtl	Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
3mv5	Crystal structure of Akt-1-inhibitor complexes
3mvh	Crystal structure of Akt-1-inhibitor complexes
3mvj	Human cyclic AMP-dependent protein kinase PKA inhibitor complex
3mvl	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K
3mvm	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7V
3mw1	p38 kinase Crystal structure in complex with small molecule inhibitor
3mwu	Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95
3my1	Structure of CDK9/cyclinT1 in complex with DRB
3my5	CDk2/cyclinA in complex with DRB
3myg	Aurora A Kinase complexed with SCH 1473759
3n51	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor RM-1-95
3n9x	Crystal structure of Map Kinase from plasmodium berghei, PB000659.00.0
3nax	PDK1 in complex with inhibitor MP7
3nay	PDK1 in complex with inhibitor MP6
3ncg	Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor NM-PP1
3ncz	X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one inhibitor
3ndm	Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative
3new	p38-alpha complexed with Compound 10
3nga	Human CK2 catalytic domain in complex with CX-4945
3nie	Crystal Structure of PF11_0147
3niz	Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with ADP bound.
3nlb	Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death
3nnu	Crystal structure of P38 alpha in complex with DP1376
3nnv	Crystal structure of P38 alpha in complex with DP437
3nnw	Crystal structure of P38 alpha in complex with DP802
3nnx	Crystal structure of phosphorylated P38 alpha in complex with DP802
3npc	Crystal structure of JNK2 complexed with BIRB796
3nr9	Structure of human CDC2-like kinase 2 (CLK2)
3nrm	Imidazo[1,2-a]pyrazine-based Aurora Kinase Inhibitors
3ns9	Crystal structure of CDK2 in complex with inhibitor BS-194
3nsz	Human CK2 catalytic domain in complex with AMPPN
3nun	phosphoinositide-dependent kinase-1 (PDK1) with lead compound
3nup	CDK6 (monomeric) in complex with inhibitor
3nus	phosphoinositide-dependent kinase-1 (PDK1) with fragment8
3nuu	phosphoinositide-dependent kinase-1 (PDK1) with fragment11
3nux	CDK6 (monomeric) in complex with inhibitor
3nuy	phosphoinositide-dependent kinase-1 (PDK1) with fragment17
3nww	P38 Alpha kinase complexed with a 2-aminothiazol-5-yl-pyrimidine based inhibitor
3nx8	human cAMP dependent protein kinase in complex with phenol
3nyn	Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin
3nyo	Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with AMP
3nyv	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with non-specific inhibitor WHI-P180
3o0g	Crystal Structure of Cdk5:p25 in complex with an ATP analogue
3o17	Crystal Structure of JNK1-alpha1 isoform
3o2m	Crystal Structure of JNK1-alpha1 isoform complex with a biaryl tetrazol (A-82118)
3o50	Crystal structure of benzamide 9 bound to AuroraA
3o51	Crystal structure of anthranilamide 10 bound to AuroraA
3o71	Crystal structure of ERK2/DCC peptide complex
3o7l	Crystal Structure of phospholamban (1-19):PKA C-subunit:AMP-PNP:Mg2+ complex
3o8p	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding
3o8t	Conformational plasticity of p38 MAP kinase DFG-motif mutants in response to inhibitor binding
3o8u	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding
3o96	Crystal Structure of Human AKT1 with an Allosteric Inhibitor
3obg	Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding
3obj	Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding
3oc1	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding
3ocb	Akt1 kinase domain with pyrrolopyrimidine inhibitor
3ocg	P38 Alpha kinase complexed with a 5-amino-pyrazole based inhibitor
3od6	Crystal structure of p38alpha Y323T active mutant
3ody	Crystal structure of p38alpha Y323Q active mutant
3odz	Crystal structure of P38alpha Y323R active mutant
3oef	Crystal structure of Y323F inactive mutant of p38alpha MAP kinase
3ofm	Structure of a human CK2alpha prime, the paralog isoform of the catalytic subunit of protein kinase CK2 from Homo sapiens
3oht	Crystal Structure of Salmo Salar p38alpha
3oog	human cAMP-dependent protein kinase in complex with a small fragment
3ori	Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 1)
3ork	Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 2)
3orl	Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 3)
3orn	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP
3oro	Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)
3orp	Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 5)
3ort	Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 6)
3orx	PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8
3orz	PDK1 mutant bound to allosteric disulfide fragment activator 2A2
3os3	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP
3ot3	X-ray crystal structure of compound 22k bound to human Chk1 kinase domain
3ot8	X-ray crystal structure of compound 17r bound to human Chk1 kinase domain
3otu	PDK1 mutant bound to allosteric disulfide fragment activator JS30
3ovv	Human cAMP-dependent protein kinase in complex with an inhibitor
3ow3	Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
3ow4	Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
3owj	Human CK2 catalytic domain in complex with a pyridocarbazole derivative inhibitor
3owk	Human CK2 catalytic domain in complex with a benzopyridoindole derivative inhibitor
3owl	Human CK2 catalytic domain in complex with a benzopyridoindole derivative inhibitor
3owp	Human cAMP-dependent protein kinase in complex with an inhibitor
3oxi	Design and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of JNK for the Treatment of Neurodegenerative Diseases
3oxt	Human cAMP-dependent protein kinase in complex with an inhibitor
3oy1	Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like Pharmacokinetic Properties
3oz6	Crystal structure of MapK from Cryptosporidium Parvum, cgd2_1960
3p0m	Human cAMP-dependent protein kinase in complex with an inhibitor
3p4k	The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution
3p5k	P38 inhibitor-bound
3p78	P38 inhibitor-bound
3p79	P38 inhibitor-bound
3p7a	p38 inhibitor-bound
3p7b	p38 inhibitor-bound
3p7c	p38 inhibitor-bound
3p9j	Aurora A kinase domain with phthalazinone pyrazole inhibitor
3pa3	X-ray crystal structure of compound 70 bound to human CHK1 kinase domain
3pa4	X-ray crystal structure of compound 2a bound to human CHK1 kinase domain
3pa5	X-ray crystal structure of compound 1 bound to human CHK1 kinase domain
3pe1	Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-4945
3pe2	Crystal structure of human protein kinase CK2 in complex with the inhibitor CX-5011
3pfq	Crystal Structure and Allosteric Activation of Protein Kinase C beta II
3pg1	MAP kinase LmaMPK10 from Leishmania major (1.95 angs resolution)
3pg3	Human p38 MAP Kinase in Complex with RL182
3pj8	Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.
3poo	human cAMP-dependent protein kinase in complex with an inhibitor
3pp1	Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP
3ppz	Crystal structure of CTR1 kinase domain in complex with staurosporine
3psc	Bovine GRK2 in complex with Gbetagamma subunits
3ptg	Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor
3pup	Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1)
3pvb	Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase
3pvg	Crystal structure of Z. mays CK2 alpha subunit in complex with the inhibitor 4,5,6,7-tetrabromo-1-carboxymethylbenzimidazole (K68)
3pvu	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
3pvw	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A)
3pwd	Crystal structure of maize CK2 in complex with NBC (Z1)
3pwy	Crystal structure of an extender (SPD28345)-modified human PDK1 complex 2
3pxf	CDK2 in complex with two molecules of 8-anilino-1-naphthalene sulfonate
3pxq	CDK2 in complex with 3 molecules of 8-anilino-1-naphthalene sulfonate
3pxr	Apo CDK2 crystallized from Jeffamine
3pxy	CDK2 in complex with inhibitor JWS648
3pxz	CDK2 ternary complex with JWS648 and ANS
3py0	CDK2 in complex with inhibitor SU9516
3py1	CDK2 ternary complex with SU9516 and ANS
3py3	Crystal structure of phosphorylated p38alpha MAP kinase
3pze	JNK1 in complex with inhibitor
3pzh	Crystal structure of maize CK2 alpha in complex with emodin at 1.92 A resolution
3q04	Crystal structure of the apo-form of human CK2 alpha at pH 8.5
3q3b	6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors
3q4z	Structure of unphosphorylated PAK1 kinase domain
3q52	Structure of phosphorylated PAK1 kinase domain
3q53	Structure of phosphorylated PAK1 kinase domain in complex with ATP
3q5i	Crystal Structure of PBANKA_031420
3q9w	Crystal structure of human CK2 alpha in complex with emodin at pH 8.5
3q9x	Crystal structure of human CK2 alpha in complex with emodin at pH 6.5
3q9y	Crystal structure of human CK2 alpha in complex with Quinalizarin at pH 8.5
3q9z	Crystal structure of human CK2 alpha in complex with Quinalizarin at pH 6.5
3qa0	Crystal structure of the apo-form of human CK2 alpha at pH 6.5
3qal	Crystal Structure of Arg280Ala mutant of Catalytic subunit of cAMP-dependent Protein Kinase
3qam	Crystal Structure of Glu208Ala mutant of catalytic subunit of cAMP-dependent protein kinase
3qbn	Structure of Human Aurora A in Complex with a diaminopyrimidine
3qc4	PDK1 in complex with DFG-OUT inhibitor xxx
3qc9	Crystal structure of cross-linked bovine GRK1 T8C/N480C double mutant complexed with ADP and Mg
3qcq	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-(3-Amino-1H-indazol-6-yl)-N4-ethyl-2,4-pyrimidinediamine
3qcs	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-[2-Amino-6-(4-morpholinyl)-4-pyrimidinyl]-1H-indazol-3-amine
3qcx	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-{2-Amino-6-[(3R)-3-methyl-4-morpholinyl]-4-pyrimidinyl}-1H-indazol-3-amine
3qcy	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 4-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide
3qd0	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide
3qd3	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl {(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate
3qd4	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate
3qf9	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a furan-thiazolidinedione ligand
3qfv	MRCK beta in complex with TPCA-1
3qhr	Structure of a pCDK2/CyclinA transition-state mimic
3qhw	Structure of a pCDK2/CyclinA transition-state mimic
3qkk	Spirochromane Akt Inhibitors
3qkl	Spirochromane Akt Inhibitors
3qkm	Spirocyclic sulfonamides as AKT inhibitors
3ql8	CDK2 in complex with inhibitor JWS-6-260
3qqf	CDK2 in complex with inhibitor L1
3qqg	CDK2 in complex with inhibitor L2-5
3qqh	CDK2 in complex with inhibitor L2-2
3qqj	CDK2 in complex with inhibitor L2
3qqk	CDK2 in complex with inhibitor L4
3qql	CDK2 in complex with inhibitor L3
3qrt	CDK2 in complex with inhibitor NSK-MC2-55
3qru	CDK2 in complex with inhibitor NSK-MC1-12
3qtq	CDK2 in complex with inhibitor RC-1-137
3qtr	CDK2 in complex with inhibitor RC-1-148
3qts	CDK2 in complex with inhibitor RC-2-12
3qtu	CDK2 in complex with inhibitor RC-2-132
3qtw	CDK2 in complex with inhibitor RC-2-13
3qtx	CDK2 in complex with inhibitor RC-2-35
3qtz	CDK2 in complex with inhibitor RC-2-36
3qu0	CDK2 in complex with inhibitor RC-2-38
3qud	Human p38 MAP Kinase in Complex with 2-amino-phenylamino-benzophenone
3que	Human p38 MAP Kinase in Complex with Skepinone-L
3qwj	CDK2 in complex with inhibitor KVR-1-142
3qwk	CDK2 in complex with inhibitor KVR-1-150
3qx2	CDK2 in complex with inhibitor KVR-1-190
3qx4	CDK2 in complex with inhibitor KVR-1-78
3qxo	CDK2 in complex with inhibitor KVR-1-84
3qxp	CDK2 in complex with inhibitor RC-3-89
3qyw	Crystal structure of ERK2 in complex with an inhibitor
3qyz	Crystal structure of ERK2 in complex with an inhibitor
3qzf	CDK2 in complex with inhibitor JWS-6-52
3qzg	CDK2 in complex with inhibitor JWS-6-76
3qzh	CDK2 in complex with inhibitor KVR-1-124
3qzi	CDK2 in complex with inhibitor KVR-1-126
3r00	The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
3r01	The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
3r02	The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
3r04	The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
3r0t	Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-5279
3r1n	MK3 kinase bound to Compound 5b
3r1q	CDK2 in complex with inhibitor KVR-1-102
3r1s	CDK2 in complex with inhibitor KVR-1-127
3r1y	CDK2 in complex with inhibitor KVR-1-134
3r21	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
3r22	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
3r28	CDK2 in complex with inhibitor KVR-1-140
3r2b	MK2 kinase bound to Compound 5b
3r2y	MK2 kinase bound to Compound 1
3r30	MK2 kinase bound to Compound 2
3r63	Structure of ERK2 (SPE) mutant (S246E)
3r6x	CDK2 in complex with inhibitor KVR-1-158
3r71	CDK2 in complex with inhibitor KVR-1-162
3r73	CDK2 in complex with inhibitor KVR-1-164
3r7e	CDK2 in complex with inhibitor KVR-1-67
3r7i	CDK2 in complex with inhibitor KVR-1-74
3r7u	CDK2 in complex with inhibitor KVR-1-75
3r7v	CDK2 in complex with inhibitor KVR-1-9
3r7y	CDK2 in complex with inhibitor KVR-2-88
3r83	CDK2 in complex with inhibitor KVR-2-92
3r8l	CDK2 in complex with inhibitor L3-4
3r8m	CDK2 in complex with inhibitor L3-3
3r8p	CDK2 in complex with inhibitor NSK-MC1-6
3r8u	CDK2 in complex with inhibitor RC-1-132
3r8v	CDK2 in complex with inhibitor RC-1-135
3r8z	CDK2 in complex with inhibitor RC-1-136
3r9d	CDK2 in complex with inhibitor RC-2-135
3r9h	CDK2 in complex with inhibitor RC-2-142
3r9n	CDK2 in complex with inhibitor RC-2-21
3r9o	CDK2 in complex with inhibitor RC-2-143
3rah	CDK2 in complex with inhibitor RC-2-22
3rai	CDK2 in complex with inhibitor KVR-1-160
3rak	CDK2 in complex with inhibitor RC-2-32
3ral	CDK2 in complex with inhibitor RC-2-34
3raw	Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41
3rcj	Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling TMS-deprotection CuAAC sequence
3rgf	Crystal Structure of human CDK8/CycC
3rin	p38 kinase crystal structure in complex with small molecule inhibitor
3rjc	CDK2 in complex with inhibitor L4-12
3rk5	CDK2 in complex with inhibitor RC-2-72
3rk7	CDK2 in complex with inhibitor RC-2-71
3rk9	CDK2 in complex with inhibitor RC-2-74
3rkb	CDK2 in complex with inhibitor RC-2-73
3rm6	CDK2 in complex with inhibitor KVR-2-80
3rm7	CDK2 in complex with inhibitor KVR-1-91
3rmf	CDK2 in complex with inhibitor RC-2-33
3rni	CDK2 in complex with inhibitor RC-3-86
3rny	Crystal structure of human RSK1 C-terminal kinase domain
3roc	Crystal structure of human p38 alpha complexed with a pyrimidinone compound
3roy	CDK2 in complex with inhibitor KVR-1-154
3rp9	Crystal Structure of the apo MapK from Toxoplasma Gondii, 25.m01780 or TGME49_007820
3rpo	CDK2 in complex with inhibitor KVR-1-156
3rpr	CDK2 in complex with inhibitor RC-2-49
3rps	Structure of human CK2alpha in complex with the ATP-competitive inhibitor 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol
3rpv	CDK2 in complex with inhibitor RC-2-88
3rpy	CDK2 in complex with inhibitor RC-2-40
3rtp	Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
3rwp	Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1)
3rwq	Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1)
3rzb	CDK2 in complex with inhibitor RC-2-23
3s00	CDK2 in complex with inhibitor L4-14
3s0o	CDK2 in complex with inhibitor RC-1-138
3s1h	CDK2 in complex with inhibitor RC-2-39
3s2p	Crystal structure of CDK2 with a 2-aminopyrimidine compound
3s3i	p38 kinase crystal structure in complex with small molecule inhibitor
3s4q	P38 alpha kinase complexed with a pyrazolo-triazine based inhibitor
3sa0	Complex of ERK2 with norathyriol
3say	Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142
3sc1	Novel Isoquinolone PDK1 Inhibitors Discovered through Fragment-Based Lead Discovery
3sd0	Identification of a Glycogen Synthase Kinase-3b Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice
3she	Novel ATP-competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series
3sls	Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP
3soa	Full-length human CaMKII
3sqq	CDK2 in complex with inhibitor RC-3-96
3sw4	Crystal Structure of the CDK2 in complex with thiazolylpyrimidine inhibitor
3sw7	Crystal Structure of the CDK2 in complex with thiazolylpyrimidine inhibitor
3sx9	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-132
3sxf	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-89
3t3u	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-130
3t3v	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-87
3t8o	Rhodopsin kinase (GRK1) L166K mutant at 2.5A resolution
3t9i	Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution
3tac	Crystal Structure of the Liprin-alpha/CASK complex
3tei	Crystal structure of human ERK2 complexed with a MAPK docking peptide
3tg1	Crystal structure of p38alpha in complex with a MAPK docking partner
3thb	Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor
3ti1	CDK2 in complex with SUNITINIB
3tiy	CDK2 in complex with NSC 35676
3tiz	CDK2 in complex with NSC 111848
3tkh	Crystal structure of Chk1 in complex with inhibitor S01
3tki	Crystal structure of Chk1 in complex with inhibitor S25
3tku	MRCK beta in complex with fasudil
3tn8	CDK9/cyclin T in complex with CAN508
3tnh	CDK9/cyclin T in complex with CAN508
3tni	structure of CDK9/cyclin T F241L
3tnp	Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
3tnq	Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
3tnw	Structure of CDK2/cyclin A in complex with CAN508
3tti	Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor
3ttj	Crystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury
3tv7	Human Rho-associated protein kinase 1 (ROCK 1) in COMPLEX WITH RKI1342
3twj	Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447
3txo	PKC eta kinase in complex with a naphthyridine
3u4u	Casein kinase 2 in complex with AZ-Inhibitor
3u87	Structure of a chimeric construct of human CK2alpha and human CK2alpha' in complex with a non-hydrolysable ATP-analogue
3u8w	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Triazolopyridazinone inhibitor
3u9c	Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit with the ATP-competitive inhibitor resorufin
3u9n	X-ray crystal structure of compound 1 bound to human CHK1 kinase domain
3ubd	Structure of N-terminal domain of RSK2 kinase in complex with flavonoid glycoside SL0101
3uc3	The crystal structure of Snf1-related kinase 2.3
3uc4	The crystal structure of Snf1-related kinase 2.6
3udb	Crystal structure of SnRK2.6
3uib	Map kinase LMAMPK10 from leishmania major in complex with SB203580
3uix	Crystal structure of Pim1 kinase in complex with small molecule inhibitor
3ujg	Crystal structure of SnRK2.6 in complex with HAB1
3uli	Human Cyclin Dependent Kinase 2 (CDK2) bound to azabenzimidazole derivative
3umw	Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one
3umx	Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indol-3-yl)methylene]-7-(azepan-1-ylmethyl)-6-hydroxybenzofuran-3(2H)-one
3unj	CDK2 in complex with inhibitor YL1-038-31
3unk	CDK2 in complex with inhibitor YL5-083
3unz	Aurora A in Complex with RPM1679
3uo4	Aurora A in complex with RPM1680
3uo5	Aurora A in complex with YL1-038-31
3uo6	Aurora A in complex with YL5-083
3uod	Aurora A in complex with RPM1693
3uoh	Aurora A in complex with RPM1722
3uoj	Aurora A in complex with RPM1715
3uok	Aurora A in complex with YL5-81-1
3uol	Aurora A in complex with SO2-162
3up2	Aurora A in complex with RPM1686
3up7	Aurora A in complex with YL1-038-09
3upx	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300
3upz	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243
3uto	Twitchin kinase region from C.elegans (Fn31-NL-kin-CRD-Ig26)
3uvp	Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone
3uvq	Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative
3uvr	Human p38 MAP Kinase in Complex with KM064
3uzs	Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex
3uzt	Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2
3v01	Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.
3v04	Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.
3v3v	Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor
3v51	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor RM-1-176
3v5p	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1288
3v5t	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1299
3v5w	Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine
3v6r	Discovery of potent and selective covalent inhibitors of JNK
3v6s	Discovery of potent and selective covalent inhibitors of JNK
3v8s	Human RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH INDAZOLE DERIVATIVE (COMPOUND 18)
3vap	Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity
3vbq	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
3vbt	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
3vbv	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
3vbw	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
3vbx	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
3vby	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
3vc4	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
3vn9	Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state
3vqh	Bromine SAD partially resolves multiple binding modes for PKA inhibitor H-89
3vqu	CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide
3vud	Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1
3vug	Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1
3vuh	Crystal structure of a cysteine-deficient mutant M3 in MAP kinase JNK1
3vui	Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1
3vuk	Crystal structure of a cysteine-deficient mutant M5 in MAP kinase JNK1
3vul	Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1
3vum	Crystal structure of a cysteine-deficient mutant M7 in MAP kinase JNK1
3vut	Crystal structures of non-phosphorylated MAP2K4
3vvh	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in complex with an inhibitor and MgATP
3vw6	Crystal structure of human apoptosis signal-regulating kinase 1 (ASK1) with imidazopyridine inhibitor
3w10	Aurora kinase A complexed to pyrazole aminoquinoline I
3w16	Structure of Aurora kinase A complexed to pyrazole-aminoquinoline inhibitor III
3w18	Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XIII
3w1f	Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide
3w2c	Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV
3w55	The structure of ERK2 in complex with FR148083
3w8l	Crystal structure of human CK2 in complex with inositol hexakisphosphate
3w8q	Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1)
3war	Crystal structure of human CK2a
3wbl	Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor
3we4	3WE4
3we8	Pim-1 kinase in complex with Ruthenium-based inhibitor
3wf5	3WF5
3wf6	3WF6
3wf7	3WF7
3wf8	3WF8
3wf9	3WF9
3wi6	Crystal structure of MAPKAP Kinase-2 (MK2) in complex with non-selective inhibitor
3wig	3WIG
3wik	3WIK
3wil	3WIL
3wow	3WOW
3wyx	3WYX
3wyy	3WYY
3wzj	3WZJ
3wzk	3WZK
3wzu	3WZU
3x2u	3X2U
3x2v	3X2V
3x2w	3X2W
3zdi	Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d
3zdu	Crystal structure of the human CDKL3 kinase domain
3zh8	A novel small molecule aPKC inhibitor
3zhp	Human MST3 (STK24) in complex with MO25beta
3zls	Crystal structure of MEK1 in complex with fragment 6
3zlw	Crystal structure of MEK1 in complex with fragment 3
3zlx	Crystal structure of MEK1 in complex with fragment 18
3zly	Crystal structure of MEK1 in complex with fragment 8
3zm4	Crystal structure of MEK1 in complex with fragment 1
3zo1	The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
3zo2	The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
3zo3	The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
3zo4	The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
3zrk	Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
3zrl	Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
3zrm	Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
3zs5	Structural basis for kinase selectivity of three clinical p38alpha inhibitors
3zsg	X-ray structure of p38alpha bound to TAK-715
3zsh	X-ray structure of p38alpha bound to SCIO-469
3zsi	X-ray structure of p38alpha bound to VX-745
3ztx	Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint sensitivity screen.
3zu7	Crystal structure of a designed selected Ankyrin Repeat protein in complex with the MAP kinase ERK2
3zut	The structure of OST1 (D160A) kinase
3zuu	The structure of OST1 (D160A, S175D) kinase in complex with gold
3zuv	Crystal structure of a designed selected Ankyrin Repeat protein in complex with the phosphorylated MAP kinase ERK2
3zxt	Dimeric structure of DAPK-1 catalytic domain in complex with AMPPCP- Mg
3zya	Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone
4a06	Human PDK1 Kinase Domain in Complex with Allosteric Activator PS114 Bound to the PIF-Pocket
4a07	Human PDK1 Kinase Domain in Complex with Allosteric Activator PS171 Bound to the PIF-Pocket
4a4l	CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 5-(2-AMINO- PYRIMIDIN-4-YL)-1H-PYRROLE INHIBITOR
4a4o	CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 2-(2-AMINO- PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLOPYRIDIN-4-ONE INHIBITOR
4a4x	NEK2-EDE bound to CCT248662
4a7c	Crystal structure of PIM1 kinase with ETP46546
4a9r	CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR
4a9s	CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR
4a9t	CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR
4a9u	CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR
4a9y	P38ALPHA MAP KINASE BOUND TO CMPD 8
4aa0	P38ALPHA MAP KINASE BOUND TO CMPD 2
4aa4	P38ALPHA MAP KINASE BOUND TO CMPD 22
4aa5	P38ALPHA MAP KINASE BOUND TO CMPD 33
4aaa	Crystal structure of the human CDKL2 kinase domain
4aac	P38ALPHA MAP KINASE BOUND TO CMPD 29
4acc	GSK3b in complex with inhibitor
4acd	GSK3b in complex with inhibitor
4acg	GSK3b in complex with inhibitor
4ach	GSK3b in complex with inhibitor
4acm	CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE
4ae6	A Crystal Structure of the Sperm Specific Isoform of Protein Kinase A (PKA) Subunit CalphaS Reveals a Binding Pocket for Hydrophobic Moieties
4ae9	A Crystal Structure of the Sperm Specific Isoform of Protein Kinase A (PKA) Subunit CalphaS Reveals a Binding Pocket for Hydrophobic Moieties
4af3	Human Aurora B Kinase in complex with INCENP and VX-680
4afe	Nek2 bound to hybrid compound 21
4afj	5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors
4agu	CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN
4alu	Benzofuropyrimidinone Inhibitors of Pim-1
4alv	Benzofuropyrimidinone Inhibitors of Pim-1
4alw	Benzofuropyrimidinone Inhibitors of Pim-1
4an2	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.
4an3	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.
4an9	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.
4anb	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.
4anm	Complex of CK2 with a CDC7 inhibitor
4aot	Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A
4apc	Crystal Structure of Human NIMA-related Kinase 1 (NEK1)
4app	Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide
4ark	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP
4as0	Cyclometalated Phthalimides as Protein Kinase Inhibitors
4au8	Crystal structure of compound 4a in complex with cdk5, showing an unusual binding mode to the hinge region via a water molecule
4aua	Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)
4aw0	Human PDK1 Kinase Domain in Complex with Allosteric Compound PS182 Bound to the PIF-Pocket
4aw1	Human PDK1 Kinase Domain in Complex with Allosteric Compound PS210 Bound to the PIF-Pocket
4aw2	Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)
4awi	Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.
4axa	Structure of PKA-PKB chimera complexed with (1S)-2-amino-1-(4- chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethan-1-ol
4aze	Human DYRK1A in complex with Leucettine L41
4azf	Human DYRK2 in complex with Leucettine L41
4b0g	Complex of Aurora-A bound to an Imidazopyridine-based inhibitor
4b4l	CRYSTAL STRUCTURE OF AN ARD DAP-KINASE 1 MUTANT
4b6l	Discovery of Oral Polo-Like Kinase (PLK) Inhibitors with Enhanced Selectivity Profile using Residue Targeted Drug Design
4b7t	Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4
4b8l	Aurora B kinase P353G mutant
4b8m	Aurora B kinase in complex with VX-680
4b99	Crystal Structure of MAPK7 (ERK5) with inhibitor
4b9d	Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.
4bbm	CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312
4bc6	Crystal structure of human serine threonine kinase-10 bound to novel Bosutinib Isoform 1, previously thought to be Bosutinib
4bcf	Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcg	Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bch	Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bci	Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcj	Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bck	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcm	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcn	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bco	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcp	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcq	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bda	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdb	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdc	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdd	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bde	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdf	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdg	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdh	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdi	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdj	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bdk	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
4bf2	Crystal Structures of Ask1-inhibitor Complexes
4bfm	The crystal structure of mouse PK38
4bgh	Crystal Structure of CDK2 in complex with pan-CDK Inhibitor
4bgq	Crystal structure of the human CDKL5 kinase domain
4bhn	Crystal Structures of Ask1-inhibitor Complexes
4bhz	Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor
4bi0	Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor
4bi1	Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor
4bi2	Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor
4bib	Crystal Structures of Ask1-inhibitor Complexes
4bic	Crystal Structures of Ask1-inhibitor Complexes
4bid	Crystal Structures of Ask1-inhibitor Complexes
4bie	Crystal Structures of Ask1-inhibitor Complexes
4bky	Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor
4bkz	Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with a benzodipyrazole inhibitor
4bl1	Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with AMP-PNP
4bn1	Crystal structure of V174M mutant of Aurora-A kinase
4byi	Aurora A kinase bound to a highly selective imidazopyridine inhibitor
4byj	Aurora A kinase bound to a highly selective imidazopyridine inhibitor
4bzd	4BZD
4bzn	Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor
4bzo	Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone inhibitor
4c0t	Candida albicans PKh Kinase Domain
4c2v	Aurora B kinase in complex with the specific inhibitor Barasertib
4c2w	Crystal structure of Aurora B in complex with AMP-PNP
4c33	PKA-S6K1 Chimera Apo
4c34	PKA-S6K1 Chimera with Staurosporine bound
4c35	PKA-S6K1 Chimera with compound 1 (NU1085) bound
4c36	PKA-S6K1 Chimera with compound 15e (CCT147581) bound
4c37	PKA-S6K1 Chimera with compound 21a (CCT196539) bound
4c38	PKA-S6K1 Chimera with compound 21e (CCT239066) bound
4c3p	4C3P
4c3r	4C3R
4c4e	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
4c4f	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
4c4g	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
4c4h	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
4c4i	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
4c4j	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
4ceg	4CEG
4cfe	Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
4cff	Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662)
4cfh	Structure of an active form of mammalian AMPK
4cfm	4CFM
4cfn	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
4cfu	4CFU
4cfv	4CFV
4cfw	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
4cfx	4CFX
4cqg	4CQG
4crl	4CRL
4crs	Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS
4ct1	4CT1
4ct2	4CT2
4cv8	4CV8
4cv9	4CV9
4cva	4CVA
4cxa	Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP
4czt	4CZT
4czu	4CZU
4d1x	4D1X
4d1z	4D1Z
4d28	4D28
4d2p	4D2P
4d2s	4D2S
4d2t	4D2T
4d2v	4D2V
4d2w	4D2W
4d9t	Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate
4d9u	Rsk2 C-terminal Kinase Domain, (E)-tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate
4daw	Crystal structure of PAK1 kinase domain with the ruthenium phthalimide complex
4dc2	Structure of PKC in Complex with a Substrate Peptide from Par-3
4dea	Aurora A in complex with YL1-038-18
4deb	Aurora A in complex with RK2-17-01
4ded	Aurora A in complex with YL1-038-21
4dee	Aurora A in complex with ADP
4dfx	Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP
4dfy	Crystal structure of R194A mutant of cAMP-dependent protein kinase with unphosphorylated activation loop
4dfz	Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20
4dg0	Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP
4dg2	Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20
4dg3	Crystal structure of R336A mutant of cAMP-dependent protein kinase with unphosphorylated turn motif.
4dgl	Crystal Structure of the CK2 Tetrameric Holoenzyme
4dgm	Crystal Structure of maize CK2 in complex with the inhibitor apigenin
4dgn	Crystal Structure of maize CK2 in complex with the inhibitor luteolin
4dgo	Crystal Structure of maize CK2 in complex with tyrphostin AG99
4dh1	Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with low Mg2+, ATP and IP20
4dh3	Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, ATP and IP20
4dh5	Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, ADP, Phosphate, and IP20
4dh7	Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, AMP-PNP and IP20'
4dh8	Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, AMP-PNP and IP20
4dhf	Structure of Aurora A mutant bound to Biogenidec cpd 15
4din	Novel Localization and Quaternary Structure of the PKA RI beta Holoenzyme
4dit	Crystal Structure of GSK3beta in complex with a Imidazopyridine inhibitor
4dli	Human p38 MAP kinase in complex with RL87
4dlj	Human p38 MAP kinase in complex with RL163
4dtk	Novel and selective pan-PIM kinase inhibitor
4e5a	The W197A mutant of p38a MAP kinase
4e5b	Structure of p38a MAP kinase without BOG
4e6a	p38a-PIA23 complex
4e6c	p38a-perifosine Complex
4e73	Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor
4e7w	Structure of GSK3 from Ustilago maydis
4e8a	The crystal structure of p38a MAP kinase in complex with PIA24
4ec8	Structure of full length CDK9 in complex with cyclinT and DRB
4ec9	Crystal structure of full-length cdk9 in complex with cyclin t
4eh2	Human p38 MAP kinase in complex with NP-F1 and RL87
4eh3	Human p38 MAP kinase in complex with NP-F2 and RL87
4eh4	Human p38 MAP kinase in complex with NP-F3 and RL87
4eh5	Human p38 MAP kinase in complex with NP-F4 and RL87
4eh6	Human p38 MAP kinase in complex with NP-F5 and RL87
4eh7	Human p38 MAP kinase in complex with NP-F6 and RL87
4eh8	Human p38 MAP kinase in complex with NP-F7 and RL87
4eh9	Human p38 MAP kinase in complex with NP-F11 and RL87
4ehv	Human p38 MAP kinase in complex with NP-F10 and RL87
4ejn	Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide
4ek3	Crystal structure of apo CDK2
4ek4	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
4ek5	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
4ek6	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
4ek8	Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor
4ekk	Akt1 with AMP-PNP
4ekl	Akt1 with GDC0068
4el9	Structure of N-terminal kinase domain of RSK2 with afzelin
4enx	Crystal Structure of Pim-1 Kinase in complex with inhibitor (2E,5Z)-2-(2-chlorophenylimino)-5-(4-hydroxy-3-nitrobenzylidene)thiazolidin-4-one
4eny	Crystal Structure of Pim-1 kinase in complex with (2E,5Z)-2-(2-chlorophenylimino)-5-(4-hydroxy-3-methoxybenzylidene)thiazolidin-4-one
4eoi	Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306
4eoj	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP
4eok	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102
4eol	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor RO3306
4eom	Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP
4eon	Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306
4eoo	Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with ATP
4eop	Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306
4eoq	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with ATP
4eor	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102
4eos	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306
4eqc	Crystal structure of PAK1 kinase domain in complex with FRAX597 inhibitor
4eqm	Structural analysis of Staphylococcus aureus serine/threonine kinase PknB
4equ	Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7
4erk	THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE
4erw	CDK2 in complex with staurosporine
4ewq	Human p38 alpha MAPK in complex with a pyridazine based inhibitor
4eyj	MAPK13 Complex with inhibitor
4eym	MAPK13 complex with inhibitor
4ez3	CDK2 in complex with NSC 134199
4ez5	CDK6 (monomeric) in complex with inhibitor
4ez7	CDK2 in complex with staurosporine and 2 molecules of 8-anilino-1-naphthalene sulfonic acid
4f6s	Crystal structure of human CDK8/CYCC in complex with compound 7 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea)
4f6u	Crystal structure of human CDK8/CYCC in complex with compound 5 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea)
4f6w	Crystal structure of human CDK8/CYCC in complex with compound 1 (N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-4-[2-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine-1-carboxamide)
4f70	Crystal structure of human CDK8/CYCC in complex with compound 4 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea)
4f7j	Crystal structure of human CDK8/CYCC in complex with compound 3 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(2-hydroxyethyl)urea)
4f7l	Crystal structure of human CDK8/CYCC in complex with compound 2 (tert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)propyl]carbamate)
4f7n	Crystal structure of human CDK8/CYCC in complex with compound 11 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea)
4f7s	Crystal structure of human CDK8/CYCC in the DMG-in conformation
4f9w	Human P38alpha MAPK in Complex with a Novel and Selective Small Molecule Inhibitor
4f9y	Human P38 alpha MAPK In Complex With a Novel and Selective Small Molecule Inhibitor
4fa2	Human P38 alpha Mitogen-Activated Kinase In Complex With SB239063
4fbx	Complex structure of human protein kinase CK2 catalytic subunit crystallized in the presence of a bisubstrate inhibitor
4fg7	Crystal structure of human calcium/calmodulin-dependent protein kinase I 1-293 in complex with ATP
4fg8	Crystal structure of human calcium/calmodulin-dependent protein kinase I 1-315 in complex with ATP
4fg9	Crystal structure of human calcium/calmodulin-dependent protein kinase I 1-320 in complex with ATP
4fgb	Crystal structure of human calcium/calmodulin-dependent protein kinase I apo form
4fie	Full-length human PAK4
4fif	Catalytic domain of human PAK4 with RPKPLVDP peptide
4fig	Catalytic domain of human PAK4
4fih	Catalytic domain of human PAK4 with QKFTGLPRQW peptide
4fii	Catalytic domain of human PAK4 with RPKPLVDP peptide
4fij	Catalytic domain of human PAK4
4fkg	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
4fki	Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor
4fkj	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
4fkl	Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor
4fko	Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor
4fkp	Crystal structure of the cdk2 in complex with oxindole inhibitor
4fkq	Crystal structure of the cdk2 in complex with oxindole inhibitor
4fkr	Crystal structure of the cdk2 in complex with oxindole inhibitor
4fks	Crystal structure of the cdk2 in complex with oxindole inhibitor
4fkt	Crystal structure of the cdk2 in complex with oxindole inhibitor
4fku	Crystal structure of the cdk2 in complex with oxindole inhibitor
4fkv	Crystal structure of the cdk2 in complex with oxindole inhibitor
4fkw	Crystal structure of the cdk2 in complex with oxindole inhibitor
4fmq	Crystal structure of human ERK2 complexed with a MAPK docking peptide
4fr4	Crystal structure of human serine/threonine-protein kinase 32A (YANK1)
4fsm	Crystal Structure of the CHK1
4fsn	Crystal Structure of the CHK1
4fsq	Crystal Structure of the CHK1
4fsr	Crystal Structure of the CHK1
4fst	Crystal Structure of the CHK1
4fsu	Crystal Structure of the CHK1
4fsw	Crystal Structure of the CHK1
4fsy	Crystal Structure of the CHK1
4fsz	Crystal Structure of the CHK1
4ft0	Crystal Structure of the CHK1
4ft3	Crystal Structure of the CHK1
4ft5	Crystal Structure of the CHK1
4ft7	Crystal Structure of the CHK1
4ft9	Crystal Structure of the CHK1
4fta	Crystal Structure of the CHK1
4ftc	Crystal Structure of the CHK1
4fti	Crystal Structure of the CHK1
4ftj	Crystal Structure of the CHK1
4ftk	Crystal Structure of the CHK1
4ftl	Crystal Structure of the CHK1
4ftm	Crystal Structure of the CHK1
4ftn	Crystal Structure of the CHK1
4fto	Crystal Structure of the CHK1
4ftq	Crystal Structure of the CHK1
4ftr	Crystal Structure of the CHK1
4ftt	Crystal Structure of the CHK1
4ftu	Crystal Structure of the CHK1
4fux	Crystal Structure of the ERK2 complexed with E75
4fuy	Crystal Structure of the ERK2 complexed with EK2
4fv0	Crystal Structure of the ERK2 complexed with EK3
4fv1	Crystal Structure of the ERK2 complexed with EK4
4fv2	Crystal Structure of the ERK2 complexed with EK5
4fv3	Crystal Structure of the ERK2 complexed with EK6
4fv4	Crystal Structure of the ERK2 complexed with EK7
4fv5	Crystal Structure of the ERK2 complexed with EK9
4fv6	Crystal Structure of the ERK2 complexed with E57
4fv7	Crystal Structure of the ERK2 complexed with E94
4fv8	Crystal Structure of the ERK2 complexed with E63
4fv9	Crystal Structure of the ERK2 complexed with E71
4fx3	Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
4fza	Crystal structure of MST4-MO25 complex
4fzd	Crystal structure of MST4-MO25 complex with WSF motif
4fzf	Crystal structure of MST4-MO25 complex with DKI
4g1w	Crystal structure of JNK1 in complex with JIP1 peptide and 7-Fluoro-3-[4-(2-hydroxy-ethanesulfonyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester
4g6l	Crystal structure of human CDK8/CYCC in the DMG-in conformation
4g6n	Crystal Structure of the ERK2
4g6o	Crystal Structure of the ERK2
4gcj	CDK2 in complex with inhibitor RC-3-89
4geo	P38a MAP kinase DEF-pocket penta mutant (M194A, L195A, H228A, I229A, Y258A)
4gh2	Crystal Structure of the CHK1
4grb	Casein kinase 2 (CK2) bound to inhibitor
4gsb	Monoclinic crystal form of the apo-ERK2
4gt3	ATP-bound form of the ERK2 kinase
4gub	Casein Kinase II bound to Inhibitor
4gue	Structure of N-terminal kinase domain of RSK2 with flavonoid glycoside quercitrin
4gv1	PKB alpha in complex with AZD5363
4gva	ADP-bound form of the ERK2 kinase
4gw8	Human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and Leucettine L41
4h36	Crystal Structure of JNK3 in Complex with ATF2 Peptide
4h39	Crystal Structure of JNK3 in Complex with JIP1 Peptide
4h3b	Crystal Structure of JNK3 in Complex with SAB Peptide
4h3p	Crystal structure of human ERK2 complexed with a MAPK docking peptide
4h3q	Crystal structure of human ERK2 complexed with a MAPK docking peptide
4hpt	Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide
4hpu	Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial phosphoryl transfer of AMP-PNP onto a substrate peptide
4hyh	X-RAY Crystal structure of compound 39 bound to human chk1 kinase domain
4hyi	X-RAY Crystal structure of compound 40 bound to human chk1 kinase domain
4hys	Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan
4hyu	Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(3-Methanesulfonyl-propoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
4i3z	Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions
4i41	Crystal Structure of human Ser/Thr kinase Pim1 in complex with mitoxantrone
4i5h	Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor
4i5m	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain
4i5p	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain
4i6b	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain
4i6f	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain
4i6h	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce alpha-Synuclein Phosphorylation in Rat Brain
4iaa	Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine
4iac	X-RAY structure of cAMP dependent protein kinase A in compelx with HIGH MG2+ concentration, AMP-PCP AND pseudo-substrate peptide SP20
4iad	Low temperature X-ray Structure OF cAMP dependent protein kinase A in compelx with high Mg2+ concentration, ADP and phosphorylated peptide pSP20
4iaf	Room temperature X-ray Structure OF cAMP dependent protein kinase A in complex with high Mg2+ concentration, ADP and phosphorylated peptide pSP20
4iai	X-ray Structure of cAMP dependent protein kinase A in complex with high Ca2+ concentration, ADP and phosphorylated peptide pSP20
4iak	Low temperature X-ray structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20
4ian	Crystal Structure of apo Human PRPF4B kinase domain
4iay	Room temperature X-ray Structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20
4iaz	Structure of cAMP dependent protein kinase A in complex with high Ba2+ concentration, ADP and phosphorylated peptide pSP20
4ib0	X-ray Structure of cAMP dependent protein kinase A in complex with high Na+ concentration, ADP and phosphorylated peptide pSP20
4ib1	Structure of cAMP dependent protein kinase A in complex with high K+ concentration, ADP and phosphorylated peptide pSP20
4ib3	Structure of cAMP dependent protein kinase A in complex with ADP, phosphorylated peptide pSP20, and no metal
4ib5	Structure of human protein kinase CK2 catalytic subunit in complex with a CK2beta-competitive cyclic peptide
4ic7	Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment
4ic8	Crystal structure of the apo ERK5 kinase domain
4ie9	Bovine PKA C-alpha in complex with 3-pyridylmethyl-5-methyl-1H-pyrazole-3-carboxylate
4ieb	Crystal Structure of a Gly128Met mutant of the toxoplasma CDPK, TGME49_101440
4ifc	Crystal Structure of ADP-bound Human PRPF4B kinase domain
4ifg	Crystal structure of TgCDPK1 with inhibitor bound
4ih8	Crystal structure of TgCDPK1 with inhibitor bound
4ihp	Crystal structure of TgCDPK1 with inhibitor bound
4ii5	Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION
4iir	Crystal Structure of AMPPNP-bound Human PRPF4B kinase domain
4ij9	Bovine PKA C-alpha in complex with 2-[[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-(2-thiophenyl)ethanone
4ijp	Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine
4imy	The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
4iq6	Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine
4ixp	Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK)
4iz5	Structure of the complex between ERK2 phosphomimetic mutant and PEA-15
4iz7	Structure of Non-Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain
4iza	Structure of Dually Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain
4izy	Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4-Methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
4j1r	Crystal Structure of GSK3b in complex with inhibitor 15R
4j52	Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor
4j53	Crystal structure of PLK1 in complex with TAK-960
4j71	Crystal Structure of GSK3b in complex with inhibitor 1R
4j7b	Crystal structure of polo-like kinase 1
4j8m	4J8M
4j8n	4J8N
4jai	Crystal Structure of Aurora Kinase A in complex with N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide
4jaj	Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE
4jbo	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
4jbp	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
4jbq	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
4jbv	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268
4jdh	Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide T peptide substrate
4jdi	Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide S peptide substrate
4jdj	Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide T peptide substrate
4jdk	Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide S peptide substrate
4jg6	RSK2 CTD bound to 2-cyano-3-(1H-indazol-5-yl)acrylamide
4jg7	Structure of RSK2 CTD bound to 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyanoacrylamide
4jg8	Structure of RSK2 T493M CTD mutant bound to 2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylamide
4jik	X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain
4jnw	Bacterially expressed Titin Kinase
4js8	Crystal structure of TTK kinase domain with an inhibitor: 401348
4jt3	Crystal Structure of TTK kinase domain with an inhibitor: 400740
4jx3	Crystal structure of Pim1 kinase
4jx7	Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one
4jxf	Crystal Structure of PLK4 Kinase with an inhibitor: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE)
4k0y	Structure of PIM-1 kinase bound to N-(4-fluorophenyl)-7-hydroxy-5-(piperidin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
4k18	Structure of PIM-1 kinase bound to 5-(4-cyanobenzyl)-N-(4-fluorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamide
4k1b	Structure of PIM-1 kinase bound to N-(5-(2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-((((3R,4R)-3-fluoropiperidin-4-yl)methyl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide
4ka3	Structure of MAP kinase in complex with a docking peptide
4kd1	CDK2 in complex with Dinaciclib
4kin	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE
4kip	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 2-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXAMIDE
4kiq	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE
4kke	The crystal structure of AMP-bound JNK3
4kkg	Crystal structure of apo and AMP-bound JNK3
4kkh	The crystal structure of inhibitor-bound JNK3
4krc	Crystal Structure of Pho85-Pcl10-ATP-gamma-S Complex
4krd	Crystal Structure of Pho85-Pcl10 Complex
4ks7	PAK6 kinase domain in complex with PF-3758309
4ks8	PAK6 kinase domain in complex with sunitinib
4kwp	Crystal Structure of Human CK2-alpha in complex with a benzimidazole inhibitor (K164) at 1.25 A resolution
4l3j	Crystal structures of human p70S6K1 kinase domain
4l3l	Crystal structures of human p70S6K1 kinase domain (Zinc anomalous)
4l42	Crystal structures of human p70S6K1-PIF
4l43	Crystal structures of human p70S6K1-T389A (form I)
4l44	Crystal structures of human p70S6K1-T389A (form II)
4l45	Crystal structures of human p70S6K1-T389E
4l46	Crystal structures of human p70S6K1-WT
4l67	Crystal Structure of Catalytic Domain of PAK4
4l6q	ROCK2 in complex with benzoxaborole
4l7f	Co-crystal Structure of JNK1 and AX13587
4l8m	Human p38 MAP kinase in complex with a Dibenzoxepinone
4l9i	Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine
4lg4	Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
4lgd	Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
4ll5	Crystal Structure of Pim-1 in complex with the fluorescent compound SKF86002
4lm5	Crystal structure of Pim1 in complex with 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol (resulting from displacement of SKF86002)
4lmn	Crystal Structure of MEK1 kinase bound to GDC0973
4lmu	Crystal structure of Pim1 in complex with the inhibitor Quercetin (resulting from displacement of SKF86002)
4loo	Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form)
4lop	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)
4loq	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)
4lqp	4LQP
4lqq	4LQQ
4lqs	4LQS
4lyn	Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3-thiazol-2-yl)-2-phenylpropanamide
4m84	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1455
4m8t	4M8T
4m97	Calcium-Dependent Protein Kinase 1 from Neospora caninum
4mao	4MAO
4mbi	Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors
4mbl	Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors
4md7	Crystal Structure of full-length symmetric CK2 holoenzyme
4md8	Crystal Structure of full-length symmetric CK2 holoenzyme with mutated alpha subunit (F121E)
4md9	Crystal Structure of symmetric CK2 holoenzyme with mutated alpha subunit (F121E truncated at aa 336)
4med	Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives
4mk0	Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
4mne	4MNE
4mq1	The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor
4mq2	The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor
4mta	4MTA
4mvf	4MVF
4mx9	CDPK1 from Neospora caninum in complex with inhibitor UW1294
4mxa	CDPK1 from Neospora caninum in complex with inhibitor RM-1-132
4myg	4MYG
4n0s	4N0S
4n4s	A Double Mutant Rat Erk2 in Complex With a Pyrazolo[3,4-d]pyrimidine Inhibitor
4n6y	Pim1 Complexed with a phenylcarboxamide
4n6z	Pim1 Complexed with a pyridylcarboxamide
4n70	Pim1 Complexed with a pyridylcarboxamide
4nct	4NCT
4nh1	Crystal structure of a heterotetrameric CK2 holoenzyme complex carrying the Andante-mutation in CK2beta and consistent with proposed models of autoinhibition and trans-autophosphorylation
4nif	4NIF
4nj3	Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor
4njd	Structure of p21-activated kinase 4 with a novel inhibitor KY-04031
4nm0	Crystal structure of peptide inhibitor-free GSK-3/Axin complex
4nm3	Crystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide
4nm5	Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif
4nm7	Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif
4nst	Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride
4nts	4NTS
4ntt	4NTT
4nu1	Crystal structure of a transition state mimic of the GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide
4nus	Rsk2 N-terminal kinase in complex with LJH685
4nw5	Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8
4nw6	Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27
4nzw	4NZW
4o0r	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
4o0s	4O0S
4o0t	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
4o0u	4O0U
4o0v	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
4o0w	4O0W
4o0x	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
4o0y	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
4o21	4O21
4o22	4O22
4o27	4O27
4o2z	Crystal Structure of MPK3 from Leishmania donovani, LdBPK_100540 in the presence of NVP-BBT594
4o6e	Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2
4o6l	4O6L
4obo	MAP4K4 in complex with inhibitor (compound 22), 6-(3-CHLOROPHENYL)QUINAZOLIN-4-AMINE
4obp	MAP4K4 in complex with inhibitor (compound 29), 6-(2-FLUOROPYRIDIN-4-YL)PYRIDO[3,2-D]PYRIMIDIN-4-AMINE
4obq	MAP4K4 in complex with inhibitor (compound 31), N-[3-(4-AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE
4ogr	crystal structure of P-TEFb complex with AFF4 and Tat
4ona	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517
4or5	Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4
4otd	4OTD
4otg	4OTG
4oth	4OTH
4oti	4OTI
4p90	4P90
4pdp	4PDP
4pds	4PDS
4pf4	1.1A X-RAY STRUCTURE OF THE APO CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE 1, aa 1-277
4pni	4PNI
4pnk	4PNK
4prj	4PRJ
4ptc	4PTC
4pte	4PTE
4ptg	4PTG
4q9z	4Q9Z
4qfg	4QFG
4qfr	4QFR
4qfs	4QFS
4qml	4QML
4qmm	4QMM
4qmn	4QMN
4qmo	4QMO
4qmp	4QMP
4qmq	4QMQ
4qms	4QMS
4qmt	4QMT
4qmu	4QMU
4qmv	4QMV
4qmw	4QMW
4qmx	4QMX
4qmy	4QMY
4qmz	4QMZ
4qna	4QNA
4qny	4QNY
4qo9	4QO9
4qox	4QOX
4qp1	4QP1
4qp2	4QP2
4qp3	4QP3
4qp4	4QP4
4qp6	4QP6
4qp7	4QP7
4qp8	4QP8
4qp9	4QP9
4qpa	4QPA
4qta	4QTA
4qtb	4QTB
4qtd	4QTD
4qte	4QTE
4qye	4QYE
4qyf	4QYF
4qyg	4QYG
4qyh	4QYH
4qyy	4QYY
4r3c	4R3C
4ra4	4RA4
4ra5	4RA5
4rbl	4RBL
4rc2	4RC2
4rc3	4RC3
4rc4	4RC4
4red	4RED
4rer	4RER
4rew	4REW
4rgj	4RGJ
4rj3	4RJ3
4rlk	4RLK
4rll	4RLL
4rlo	4RLO
4rlp	4RLP
4rpv	4RPV
4rqk	4RQK
4rqv	4RQV
4rrv	4RRV
4rvk	4RVK
4rvl	4RVL
4rvm	4RVM
4rvt	4RVT
4rz7	4RZ7
4s2z	4S2Z
4s30	4S30
4s31	4S31
4s32	4S32
4s33	4S33
4s34	4S34
4tl0	4TL0
4tnb	4TNB
4tnd	4TND
4tth	4TTH
4txc	4TXC
4ty1	4TY1
4tyh	4TYH
4tzr	4TZR
4u3y	4U3Y
4u3z	4U3Z
4u40	4U40
4u41	4U41
4u42	4U42
4u43	4U43
4u44	4U44
4u45	4U45
4u79	4U79
4u7z	4U7Z
4u80	4U80
4u81	4U81
4u8z	4U8Z
4uak	4UAK
4ual	4UAL
4ub7	4UB7
4uba	4UBA
4uj1	4UJ1
4uj2	4UJ2
4uj9	4UJ9
4uja	4UJA
4ujb	4UJB
4ump	4UMP
4umq	4UMQ
4umr	4UMR
4umt	4UMT
4umu	4UMU
4un0	4UN0
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5t6a	5T6A
5t6i	5T6I
5t6k	5T6K

Links (links to other resources describing this domain)

• INTERPRO: IPR000719
• PFAM: pkinase