SMART: btg1 domain annotation

btg1 tob/btg1 family

SMART accession number:	SM00099
Description:	The tob/btg1 is a family of proteins that inhibit cell proliferation.
Interpro abstract (IPR002087):	This entry represents a conserved domain found in the N-terminal of the BTG family members (also known as anti-proliferative proteins). In mammals, BTG family comprises six proteins: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They regulate cell cycle progression in a variety of cell types [ (PUBMED:19746446) ]. These proteins have from 158 to 363 amino acid residues, that are highly similar and include 3 conserved cysteine residues. BTG2 seems to have a signal sequence; while the other proteins may lack such a domain.
Family alignment:	View or

There are 1150 btg1 domains in 1147 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing btg1 domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with btg1 domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing btg1 domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Rouault JP et al.
- BTG1, a member of a new family of antiproliferative genes.
- EMBO J. 1992; 11: 1663-70
- Display abstract
- The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. We report here the cloning and sequencing of the human BTG1 cDNA and establish the genomic organization of this gene. The full-length cDNA isolated from a lymphoblastoid cell line contains an open reading frame of 171 amino acids. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and is down-regulated when cells progress throughout G1. Furthermore, transfection experiments of NIH3T3 cells indicate that BTG1 negatively regulates cell proliferation. The BTG1 open reading frame is 60% homologous to PC3, an immediate early gene induced by nerve growth factor in rat PC12 cells. Sequence and Northern blot analyses indicate that BTG1 and PC3 are not cognate genes. We then postulate that these two genes are the first members of a new family of antiproliferative genes.
Structure (3D structures containing this domain)

Links (links to other resources describing this domain)
INTERPRO IPR002087
PFAM Anti_proliferat
PROSITE BTG1_2

PDB code	Main view	Title
2d5r		Crystal Structure of a Tob-hCaf1 Complex
2z15		Crystal structure of human Tob1 protein
3djn		Crystal structure of mouse TIS21
3dju		Crystal structure of human BTG2
3e9v		Crystal structure of human B-cell Translocation Gene 2 (BTG2)
5ci8		5CI8
5ci9		5CI9

INTERPRO	IPR002087
PFAM	Anti_proliferat
PROSITE	BTG1_2

btg1

Taxonomic distribution of proteins containing btg1 domain.

3D Structures of btg1 domains in PDB