cNMPCyclic nucleotide-monophosphate binding domain |
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SMART accession number: | SM00100 |
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Description: | Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases. |
Interpro abstract (IPR000595): | Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [ (PUBMED:14638413) (PUBMED:10550204) (PUBMED:1710853) ]. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signal transduction. |
Family alignment: |
There are 149838 cNMP domains in 136080 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing cNMP domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with cNMP domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing cNMP domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
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Binding / catalysis: cAMP-binding, cGMP-binding
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Shabb JB, Poteet CE, Kapphahn MA, Muhonen WM, Baker NE, Corbin JD
- Characterization of the isolated cAMP-binding B domain of cAMP-dependent protein kinase.
- Protein Sci. 1995; 4: 2100-6
- Display abstract
A 14.4-kDa cAMP-binding fragment was generated during bacterial expression and purification of recombinant bovine cAMP-dependent protein kinase type I alpha regulatory subunit (RI alpha). The full-length RI alpha from which the fragment was derived contained a point mutation allowing its B domain to bind both cAMP and cGMP with high affinity while leaving its A domain highly cAMP selective. The NH2 terminus of the fragment was Ser-252, indicating that it encompassed the entire predicted B domain. Although the [3H]cAMP and [3H]cGMP exchange rates of the isolated B domain were increased relative to the B domain in intact RI alpha, the [3H]cAMP exchange rate was comparable to that of the B domain of full-length RI alpha containing an unoccupied A domain. A plasmid encoding only the isolated B domain was overexpressed in Escherichia coli, and a monomeric form of the B domain was purified that had identical properties to the proteolytically generated fragment, indicating that all of the elements for the high-affinity cAMP-binding B domain are contained within the 128 amino acid carboxyl terminus of the R subunit. Prolonged induction of the B domain in E. coli or storage of the purified protein resulted in the formation of a dimer that could be reverted to the monomer by incubation in 2-mercaptoethanol. Dimerization caused an approximate fivefold increase in the rate of cyclic nucleotide exchange relative to the monomer. The results show that an isolated cAMP-binding domain can function independently of any other domain structures of the R subunit.
- Schultz SC, Shields GC, Steitz TA
- Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees.
- Science. 1991; 253: 1001-7
- Display abstract
The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30-base pair DNA sequence shows that the DNA is bent by 90 degrees. This bend results almost entirely from two 40 degrees kinks that occur between TG/CA base pairs at positions 5 and 6 on each side of the dyad axis of the complex. DNA sequence discrimination by CAP derives both from sequence-dependent distortion of the DNA helix and from direct hydrogen-bonding interactions between three protein side chains and the exposed edges of three base pairs in the major groove of the DNA. The structure of this transcription factor--DNA complex provides insights into possible mechanisms of transcription activation.
- Weber IT, Steitz TA, Bubis J, Taylor SS
- Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase.
- Biochemistry. 1987; 26: 343-51
- Display abstract
The mammalian cAMP-dependent protein kinases have regulatory (R) subunits that show substantial homology in amino acid sequence with the catabolite gene activator protein (CAP), a cAMP-dependent gene regulatory protein from Escherichia coli. Each R subunit has two in-tandem cAMP binding domains, and the structure of each of these domains has been modeled by analogy with the crystal structure of CAP. Both the type I and II regulatory subunits have been considered, so that four cAMP binding domains have been modeled. The binding of cAMP in general is analogous in all the structures and has been correlated with previous results based on photolabeling and binding of cAMP analogues. The model predicts that the first cAMP binding domain correlates with the previously defined fast dissociation site, which preferentially binds N6-substituted analogues of cAMP. The second domain corresponds to the slow dissociation site, which has a preference for C8-substituted analogues. The model also is consistent with cAMP binding in the syn conformation in both sites. Finally, this model has targeted specific regions that are likely to be involved in interdomain contacts. This includes contacts between the two cAMP binding domains as well as contacts with the amino-terminal region of the R subunit and with the catalytic subunit.
- McKay DB, Steitz TA
- Structure of catabolite gene activator protein at 2.9 A resolution suggests binding to left-handed B-DNA.
- Nature. 1981; 290: 744-9
- Display abstract
The 2.9 A resolution crystal structure of Escherichia coli catabolite gene activator protein (CAP) complexed with cyclic AMP reveals two distinct structural domains separated by a cleft. The smaller carboxy-terminal domain is presumed to bind DNA while the amino-terminal domain is seen to bind cyclic AMP. Model building studies suggest that CAP binds to left-handed B-type DNA, contracting its major groove via two alpha-helices. It is possible that the CAP conversion of right- to left-handed DNA in a closed supercoil, is what activates transcription by RNA polymerase.
- McKay DB, Fried MG
- Crystallization and preliminary X-ray diffraction data for the cyclic AMP receptor protein of Escherichia coli.
- J Mol Biol. 1980; 139: 95-6
- Disease (disease genes where sequence variants are found in this domain)
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SwissProt sequences and OMIM curated human diseases associated with missense mutations within the cNMP domain.
Protein Disease Potassium voltage-gated channel subfamily H member 2 (Q12809) (SMART) OMIM:152427: Long QT syndrome-2 Cyclic nucleotide-gated cation channel alpha-3 (Q16281) (SMART) OMIM:216900: Achromatopsia
OMIM:600053: Achromatopsia-2
OMIM:216900: - Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 16.00 map04740 Olfactory transduction 12.44 map04210 Apoptosis 12.44 map04910 Insulin signaling pathway 8.89 map02010 ABC transporters - General 8.00 map00240 Pyrimidine metabolism 7.11 map04540 Gap junction 7.11 map04730 Long-term depression 6.67 map04670 Leukocyte transendothelial migration 3.56 map00910 Nitrogen metabolism 3.56 map04720 Long-term potentiation 3.11 map00251 Glutamate metabolism 3.11 map00471 D-Glutamine and D-glutamate metabolism 2.22 map04010 MAPK signaling pathway 1.33 map00620 Pyruvate metabolism 0.89 map00632 Benzoate degradation via CoA ligation 0.44 map00562 Inositol phosphate metabolism 0.44 map00190 Oxidative phosphorylation 0.44 map00252 Alanine and aspartate metabolism 0.44 map00903 Limonene and pinene degradation 0.44 map00330 Arginine and proline metabolism 0.44 map03090 Type II secretion system 0.44 map00430 Taurine and hypotaurine metabolism 0.44 map00640 Propanoate metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with cNMP domain which could be assigned to a KEGG orthologous group, and not all proteins containing cNMP domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of cNMP domains in PDB
PDB code Main view Title 1cgp CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE 1cx4 CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE 1ft9 STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM 1g6n 2.1 ANGSTROM STRUCTURE OF CAP-CAMP 1hw5 THE CAP/CRP VARIANT T127L/S128A 1i5z STRUCTURE OF CRP-CAMP AT 1.9 A 1i6x STRUCTURE OF A STAR MUTANT CRP-CAMP AT 2.2 A 1j59 CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE 1lb2 Structure of the E. coli alpha C-terminal domain of RNA polymerase in complex with CAP and DNA 1ne4 Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase 1ne6 Crystal structure of Sp-cAMP binding R1a subunit of cAMP-dependent protein kinase 1o3q PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES 1o3r PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES 1o3s PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES 1o3t PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES 1o5l Crystal structure of Transcriptional regulator (TM1171) from Thermotoga maritima at 2.30 A resolution 1o7f CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2 1q3e HCN2J 443-645 in the presence of cGMP 1q43 HCN2I 443-640 in the presence of cAMP, selenomethionine derivative 1q5o HCN2J 443-645 in the presence of cAMP, selenomethionine derivative 1rgs REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE 1rl3 Crystal structure of cAMP-free R1a subunit of PKA 1run CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE 1ruo CATABOLITE GENE ACTIVATOR PROTEIN (CAP) MUTANT/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE 1u12 M. loti cyclic nucleotide binding domain mutant 1vp6 M.loti ion channel cylic nucleotide binding domain 1wgp Solution structure of the cNMP-binding domain from Arabidopsis thaliana cyclic nucleotide-regulated ion channel 1zrc 4 Crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-ICAP38 DNA 1zrd 4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6A;17T]ICAP38 DNA 1zre 4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6G;17C]ICAP38 DNA 1zrf 4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6C;17G]ICAP38 DNA 1zyb Crystal structure of transcription regulator from Bacteroides thetaiotaomicron VPI-5482 at 2.15 A resolution 2byv Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state 2cgp CATABOLITE GENE ACTIVATOR PROTEIN/DNA COMPLEX, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE 2d93 Solution structure of the cNMP_binding domain of human Rap guanine nucleotide exchange factor 6 2fmy CO-dependent transcription factor CooA from Carboxydothermus hydrogenoformans (Imidazole-bound form) 2gau Crystal structure of transcriptional regulator, Crp/Fnr family from Porphyromonas gingivalis (APC80792), Structural genomics, MCSG 2gzw Crystal structure of the E.coli CRP-cAMP complex 2h6b Crystal structure of oxidized CprK in complex with o-chlorophenolacetic acid 2h6c Crystal structure of reduced CprK in absence of any ligand 2hkx Structure of CooA mutant (N127L/S128L) from Carboxydothermus hydrogenoformans 2k0g Solution Structure of a Bacterial Cyclic Nucleotide-Activated K+ Channel Binding Domain in Complex with cAMP 2kxl Solution structure of a bacterial cyclic nucleotide-activated K+ channel binding domain in the unliganded state 2mhf Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel 2mng 2MNG 2mpf 2MPF 2n7g 2N7G 2oz6 Crystal Structure of Virulence Factor Regulator from Pseudomonas aeruginosa in complex with cAMP 2pqq Structural Genomics, the crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2) 2ptm Structure and rearrangements in the carboxy-terminal region of SpIH channels 2q0a Structure and rearrangements in the carboxy-terminal region of SpIH channels 2qcs A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state 2qvs Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase 2wc2 Nmr structure of catabolite activator protein in the unliganded state 2xgx Crystal structure of transcription factor NtcA from Synechococcus elongatus (mercury derivative) 2xhk Crystal structure of transcription factor NtcA from Synechococcus elongatus bound to 2-oxoglutarate 2xko Crystal structure of the complex of NtcA with its transcriptional co- activator PipX 2xkp NtcA from Synechococcus elongatus: active and inactive 2z69 Crystal Structure of the sensor domain of the transcriptional regulator DNR from Pseudomonas aeruginosa 2zcw Crystal Structure of TTHA1359, a Transcriptional Regulator, CRP/FNR family from Thermus thermophilus HB8 2zd9 Structure of a Bacterial Cyclic-Nucleotide Regulated Ion Channel 3b02 Crystal structure of TTHB099, a transcriptional regulator CRP family from Thermus thermophilus HB8 3beh Structure of a Bacterial Cyclic Nucleotide Regulated Ion Channel 3bpz HCN2-I 443-460 E502K in the presence of cAMP 3cf6 Structure of Epac2 in complex with cyclic-AMP and Rap 3cl1 M. loti cyclic-nucleotide binding domain, cyclic-GMP bound 3clp M. loti cyclic-nucleotide binding domain mutant 2 3co2 Mlotik1 ion channel cyclic-nucleotide binding domain mutant 3d0s cAMP receptor protein from m.tuberculosis, cAMP-free form 3dkw Crystal Structure of DNR from Pseudomonas aeruginosa. 3dn7 Cyclic nucleotide binding regulatory protein from Cytophaga hutchinsonii. 3dv8 Crystal structure of a putative transcriptional regulator of the crp/fnr family (eubrec_1222) from eubacterium rectale atcc 33656 at 2.55 A resolution 3e5q Unbound Oxidised CprK 3e5u OCPA complexed CprK (C200S) 3e5x OCPA complexed CprK 3e6b OCPA complexed CprK (C200S) 3e6c CprK OCPA DNA Complex 3e6d Crystal Structure of CprK C200S 3e97 Crystal structure of transcriptional regulator of Crp/Fnr family (YP_604437.1) from DEINOCOCCUS GEOTHERMALIS DSM 11300 at 1.86 A resolution 3etq X-ray structure of cysteine-free fragment of mHCN2 C-terminal region from amino acids 443-630 including C508N, C584S, and C601S mutations 3ffq HCN2I 443-640 apo-state 3fhi Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA 3fwe Crystal Structure of the Apo D138L CAP mutant 3fx3 Structure of a putative cAMP-binding regulatory protein from Silicibacter pomeroyi DSS-3 3gyd Crystal structure of a cyclic nucleotide-binding domain (mfla_1926) from methylobacillus flagellatus kt at 1.79 A resolution 3h3u Crystal structure of CRP (cAMP receptor Protein) from Mycobacterium tuberculosis 3h3z Crystal structure of a putative cyclic nucleotide binding protein (spoa0323) from ruegeria pomeroyi dss-3 at 2.35 A resolution 3hif The crystal structure of apo wild type CAP at 3.6 A resolution. 3i54 Crystal structure of MtbCRP in complex with cAMP 3i59 Crystal structure of MtbCRP in complex with N6-cAMP 3idb Crystal structure of (108-268)RIIb:C holoenzyme of cAMP-dependent protein kinase 3idc Crystal structure of (102-265)RIIb:C holoenzyme of cAMP-dependent protein kinase 3iia Crystal structure of apo (91-244) RIa subunit of cAMP-dependent protein kinase 3iwz The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris 3iyd Three-dimensional EM structure of an intact activator-dependent transcription initiation complex 3j4q Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from electron microscopy 3j4r Pseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopy 3kcc Crystal structure of D138L mutant of Catabolite Gene Activator Protein 3la2 Crystal structure of NtcA in complex with 2-oxoglutarate 3la3 Crystal structure of NtcA in complex with 2,2-difluoropentanedioic acid 3la7 Crystal structure of NtcA in apo-form 3mdp Crystal structure of a Putative Cyclic nucleotide-binding protein (Gmet_1532) from Geobacter metallireducens GS-15 at 1.90 A resolution 3mzh Crystal structure of cAMP receptor protein from mycobacterium tuberculosis in complex with cAMP and its DNA binding element 3n4m E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA 3ocp Crystal structure of cAMP bound cGMP-dependent protein kinase(92-227) 3od0 Crystal structure of cGMP bound cGMP-dependent protein kinase(92-227) 3of1 Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA 3ogj Crystal structure of partial apo (92-227) of cGMP-dependent protein kinase 3otf Structural basis for the cAMP-dependent gating in human HCN4 channel 3plq Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS 3pna Crystal Structure of cAMP bound (91-244)RIa Subunit of cAMP-dependent Protein Kinase 3pvb Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase 3qop Domain-domain flexibility leads to allostery within the camp receptor protein (CRP) 3r6s Crystal structure of GlxR transcription factor from Corynebacterium glutamicum with cAMP 3rdi Domain-domain flexibility leads to allostery within the camp receptor protein (CRP) 3rou Domain-domain flexibility leads to allostery within the camp receptor protein (CRP) 3rpq Domain-domain flexibility leads to allostery within the camp receptor protein (CRP) 3ryp Domain-domain flexibility leads to allostery within the camp receptor protein (CRP) 3ryr Domain-domain flexibility leads to allostery within the camp receptor protein (CRP) 3shr Crystal Structure of cGMP-dependent Protein Kinase Reveals Novel Site of Interchain Communication 3tnp Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme 3tnq Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme 3u0z Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels 3u10 Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels 3u11 Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels 3ukn Structure of the C-linker/CNBHD of zELK channels in C 2 2 21 space group 3ukt Structure of the C-linker/CNBHD of zELK channels in P1 21 1 space group 3ukv Structure of the C-linker/CNBHD of zELK channels in P 1 21 1 space group, crystallized in the presence of cAMP 4a2u CRP(CAP) from Myco. Tuberculosis, with cAMP 4ava Crystal structure of protein lysine acetyltransferase Rv0998 from Mycobacterium tuberculosis 4avb Crystal structure of protein lysine acetyltransferase Rv0998 in complex with acetyl CoA and cAMP 4avc Crystal structure of protein lysine acetyltransferase Rv0998 in complex with acetyl CoA and cAMP 4bh9 A structural model of CAP mutant (T127L and S128I) in the apo state 4bhp A structural model of CAP mutant (T127L and S128I) in cGMP-bound state 4byy 4BYY 4chv The electron crystallography structure of the cAMP-bound potassium channel MloK1 4chw The electron crystallography structure of the cAMP-free potassium channel MloK1 4cyd 4CYD 4d7s 4D7S 4d7t 4D7T 4din Novel Localization and Quaternary Structure of the PKA RI beta Holoenzyme 4ev0 Crystal Structure of Thermus thermophilus Catabolite Activator Protein 4f7z Conformational dynamics of exchange protein directly activated by cAMP 4f8a Cyclic nucleotide binding-homology domain from mouse EAG1 potassium channel 4ft8 E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands 4hbn Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation 4hzf structure of the wild type Catabolite gene Activator Protein 4i01 Structure of the mutant Catabolite gen activator protein V140L 4i02 structure of the mutant Catabolite gene activator protein V140A 4i09 structure of the mutant Catabolite gene activator protein V132L 4i0a structure of the mutant Catabolite gene activator protein V132A 4i0b structure of the mutant Catabolite gene activator protein H160L 4i2o The Structure of FixK2 from Bradyrhizobium japonicum 4jv4 Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog 4jva Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog 4k8f Structure of the heme domain of CooA from Rhodospirillum rubrum 4kg1 cGMP-responsive diguanylate cyclase 4kl1 HCN4 CNBD in complex with cGMP 4ku7 Structures of PKGI Reveal a cGMP-Selective Activation Mechanism 4ku8 Structures of PKGI Reveal a cGMP-Selective Activation Mechanism 4l11 Structure of the C-linker/CNBHD of agERG channels 4llo Structure of the eag domain-CNBHD complex of the mouse EAG1 channel 4mgi 4MGI 4mgk 4MGK 4mgy 4MGY 4mgz 4MGZ 4mh0 4MH0 4muv 4MUV 4mx3 Crystal Structure of PKA RIalpha Homodimer 4n9h 4N9H 4n9i 4N9I 4nvp Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP 4off 4OFF 4ofg 4OFG 4oll cAMP-binding acyltransferase from Mycobacterium smegmatis 4onu cAMP-binding acyltransferase from Mycobacterium smegmatis, E234A mutant 4orf cAMP-binding acyltransferase from Mycobacterium smegmatis, mutant R95K 4qx5 4QX5 4qxk 4QXK 4r8h 4R8H 4rz7 4RZ7 4wbb 4WBB 4x6q 4X6Q 4x6r 4X6R 4z07 4Z07 5bv6 5BV6 5c6c 5C6C 5c8w 5C8W 5ciz 5CIZ 5cvr 5CVR 5d1i 5D1I 5dyk 5DYK 5dyl 5DYL 5dzc 5DZC 5e16 5E16 5e44 5E44 5f0a 5F0A 5fet 5FET 5i2d 5I2D 5j3u 5J3U 5jon 5JON 5k7l 5K7L 5k8s 5K8S 5kbf 5KBF 5khg 5KHG 5khh 5KHH 5khi 5KHI 5khj 5KHJ 5khk 5KHK 5t3n 5T3N - Links (links to other resources describing this domain)
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PFAM cNMP_binding INTERPRO IPR000595