cNMP

Cyclic nucleotide-monophosphate binding domain

• SMART accession number: SM00100
• Description: Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.
• Interpro abstract (IPR000595):

  Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [ (PUBMED:14638413) (PUBMED:10550204) (PUBMED:1710853) ]. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signal transduction.

There are 149838 cNMP domains in 136080 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Binding / catalysis: cAMP-binding, cGMP-binding

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Shabb JB, Poteet CE, Kapphahn MA, Muhonen WM, Baker NE, Corbin JD
• Characterization of the isolated cAMP-binding B domain of cAMP-dependent protein kinase.
• Protein Sci. 1995; 4: 2100-6

A 14.4-kDa cAMP-binding fragment was generated during bacterial expression and purification of recombinant bovine cAMP-dependent protein kinase type I alpha regulatory subunit (RI alpha). The full-length RI alpha from which the fragment was derived contained a point mutation allowing its B domain to bind both cAMP and cGMP with high affinity while leaving its A domain highly cAMP selective. The NH2 terminus of the fragment was Ser-252, indicating that it encompassed the entire predicted B domain. Although the [3H]cAMP and [3H]cGMP exchange rates of the isolated B domain were increased relative to the B domain in intact RI alpha, the [3H]cAMP exchange rate was comparable to that of the B domain of full-length RI alpha containing an unoccupied A domain. A plasmid encoding only the isolated B domain was overexpressed in Escherichia coli, and a monomeric form of the B domain was purified that had identical properties to the proteolytically generated fragment, indicating that all of the elements for the high-affinity cAMP-binding B domain are contained within the 128 amino acid carboxyl terminus of the R subunit. Prolonged induction of the B domain in E. coli or storage of the purified protein resulted in the formation of a dimer that could be reverted to the monomer by incubation in 2-mercaptoethanol. Dimerization caused an approximate fivefold increase in the rate of cyclic nucleotide exchange relative to the monomer. The results show that an isolated cAMP-binding domain can function independently of any other domain structures of the R subunit.

• Schultz SC, Shields GC, Steitz TA
• Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees.
• Science. 1991; 253: 1001-7

The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30-base pair DNA sequence shows that the DNA is bent by 90 degrees. This bend results almost entirely from two 40 degrees kinks that occur between TG/CA base pairs at positions 5 and 6 on each side of the dyad axis of the complex. DNA sequence discrimination by CAP derives both from sequence-dependent distortion of the DNA helix and from direct hydrogen-bonding interactions between three protein side chains and the exposed edges of three base pairs in the major groove of the DNA. The structure of this transcription factor--DNA complex provides insights into possible mechanisms of transcription activation.

• Weber IT, Steitz TA, Bubis J, Taylor SS
• Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase.
• Biochemistry. 1987; 26: 343-51

The mammalian cAMP-dependent protein kinases have regulatory (R) subunits that show substantial homology in amino acid sequence with the catabolite gene activator protein (CAP), a cAMP-dependent gene regulatory protein from Escherichia coli. Each R subunit has two in-tandem cAMP binding domains, and the structure of each of these domains has been modeled by analogy with the crystal structure of CAP. Both the type I and II regulatory subunits have been considered, so that four cAMP binding domains have been modeled. The binding of cAMP in general is analogous in all the structures and has been correlated with previous results based on photolabeling and binding of cAMP analogues. The model predicts that the first cAMP binding domain correlates with the previously defined fast dissociation site, which preferentially binds N6-substituted analogues of cAMP. The second domain corresponds to the slow dissociation site, which has a preference for C8-substituted analogues. The model also is consistent with cAMP binding in the syn conformation in both sites. Finally, this model has targeted specific regions that are likely to be involved in interdomain contacts. This includes contacts between the two cAMP binding domains as well as contacts with the amino-terminal region of the R subunit and with the catalytic subunit.

• McKay DB, Steitz TA
• Structure of catabolite gene activator protein at 2.9 A resolution suggests binding to left-handed B-DNA.
• Nature. 1981; 290: 744-9

The 2.9 A resolution crystal structure of Escherichia coli catabolite gene activator protein (CAP) complexed with cyclic AMP reveals two distinct structural domains separated by a cleft. The smaller carboxy-terminal domain is presumed to bind DNA while the amino-terminal domain is seen to bind cyclic AMP. Model building studies suggest that CAP binds to left-handed B-type DNA, contracting its major groove via two alpha-helices. It is possible that the CAP conversion of right- to left-handed DNA in a closed supercoil, is what activates transcription by RNA polymerase.

• McKay DB, Fried MG
• Crystallization and preliminary X-ray diffraction data for the cyclic AMP receptor protein of Escherichia coli.
• J Mol Biol. 1980; 139: 95-6

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the cNMP domain.

Protein	Disease
Potassium voltage-gated channel subfamily H member 2 (Q12809) (SMART)	OMIM:152427: Long QT syndrome-2
Cyclic nucleotide-gated cation channel alpha-3 (Q16281) (SMART)	OMIM:216900: Achromatopsia OMIM:600053: Achromatopsia-2 OMIM:216900:

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
16.00	map04740	Olfactory transduction
12.44	map04210	Apoptosis
12.44	map04910	Insulin signaling pathway
8.89	map02010	ABC transporters - General
8.00	map00240	Pyrimidine metabolism
7.11	map04540	Gap junction
7.11	map04730	Long-term depression
6.67	map04670	Leukocyte transendothelial migration
3.56	map00910	Nitrogen metabolism
3.56	map04720	Long-term potentiation
3.11	map00251	Glutamate metabolism
3.11	map00471	D-Glutamine and D-glutamate metabolism
2.22	map04010	MAPK signaling pathway
1.33	map00620	Pyruvate metabolism
0.89	map00632	Benzoate degradation via CoA ligation
0.44	map00562	Inositol phosphate metabolism
0.44	map00190	Oxidative phosphorylation
0.44	map00252	Alanine and aspartate metabolism
0.44	map00903	Limonene and pinene degradation
0.44	map00330	Arginine and proline metabolism
0.44	map03090	Type II secretion system
0.44	map00430	Taurine and hypotaurine metabolism
0.44	map00640	Propanoate metabolism

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with cNMP domain which could be assigned to a KEGG orthologous group, and not all proteins containing cNMP domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of cNMP domains in PDB

PDB code	Title
1cgp	CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
1cx4	CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
1ft9	STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM
1g6n	2.1 ANGSTROM STRUCTURE OF CAP-CAMP
1hw5	THE CAP/CRP VARIANT T127L/S128A
1i5z	STRUCTURE OF CRP-CAMP AT 1.9 A
1i6x	STRUCTURE OF A STAR MUTANT CRP-CAMP AT 2.2 A
1j59	CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
1lb2	Structure of the E. coli alpha C-terminal domain of RNA polymerase in complex with CAP and DNA
1ne4	Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase
1ne6	Crystal structure of Sp-cAMP binding R1a subunit of cAMP-dependent protein kinase
1o3q	PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES
1o3r	PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES
1o3s	PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES
1o3t	PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES
1o5l	Crystal structure of Transcriptional regulator (TM1171) from Thermotoga maritima at 2.30 A resolution
1o7f	CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2
1q3e	HCN2J 443-645 in the presence of cGMP
1q43	HCN2I 443-640 in the presence of cAMP, selenomethionine derivative
1q5o	HCN2J 443-645 in the presence of cAMP, selenomethionine derivative
1rgs	REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
1rl3	Crystal structure of cAMP-free R1a subunit of PKA
1run	CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
1ruo	CATABOLITE GENE ACTIVATOR PROTEIN (CAP) MUTANT/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
1u12	M. loti cyclic nucleotide binding domain mutant
1vp6	M.loti ion channel cylic nucleotide binding domain
1wgp	Solution structure of the cNMP-binding domain from Arabidopsis thaliana cyclic nucleotide-regulated ion channel
1zrc	4 Crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-ICAP38 DNA
1zrd	4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6A;17T]ICAP38 DNA
1zre	4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6G;17C]ICAP38 DNA
1zrf	4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6C;17G]ICAP38 DNA
1zyb	Crystal structure of transcription regulator from Bacteroides thetaiotaomicron VPI-5482 at 2.15 A resolution
2byv	Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state
2cgp	CATABOLITE GENE ACTIVATOR PROTEIN/DNA COMPLEX, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
2d93	Solution structure of the cNMP_binding domain of human Rap guanine nucleotide exchange factor 6
2fmy	CO-dependent transcription factor CooA from Carboxydothermus hydrogenoformans (Imidazole-bound form)
2gau	Crystal structure of transcriptional regulator, Crp/Fnr family from Porphyromonas gingivalis (APC80792), Structural genomics, MCSG
2gzw	Crystal structure of the E.coli CRP-cAMP complex
2h6b	Crystal structure of oxidized CprK in complex with o-chlorophenolacetic acid
2h6c	Crystal structure of reduced CprK in absence of any ligand
2hkx	Structure of CooA mutant (N127L/S128L) from Carboxydothermus hydrogenoformans
2k0g	Solution Structure of a Bacterial Cyclic Nucleotide-Activated K+ Channel Binding Domain in Complex with cAMP
2kxl	Solution structure of a bacterial cyclic nucleotide-activated K+ channel binding domain in the unliganded state
2mhf	Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel
2mng	2MNG
2mpf	2MPF
2n7g	2N7G
2oz6	Crystal Structure of Virulence Factor Regulator from Pseudomonas aeruginosa in complex with cAMP
2pqq	Structural Genomics, the crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2)
2ptm	Structure and rearrangements in the carboxy-terminal region of SpIH channels
2q0a	Structure and rearrangements in the carboxy-terminal region of SpIH channels
2qcs	A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state
2qvs	Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase
2wc2	Nmr structure of catabolite activator protein in the unliganded state
2xgx	Crystal structure of transcription factor NtcA from Synechococcus elongatus (mercury derivative)
2xhk	Crystal structure of transcription factor NtcA from Synechococcus elongatus bound to 2-oxoglutarate
2xko	Crystal structure of the complex of NtcA with its transcriptional co- activator PipX
2xkp	NtcA from Synechococcus elongatus: active and inactive
2z69	Crystal Structure of the sensor domain of the transcriptional regulator DNR from Pseudomonas aeruginosa
2zcw	Crystal Structure of TTHA1359, a Transcriptional Regulator, CRP/FNR family from Thermus thermophilus HB8
2zd9	Structure of a Bacterial Cyclic-Nucleotide Regulated Ion Channel
3b02	Crystal structure of TTHB099, a transcriptional regulator CRP family from Thermus thermophilus HB8
3beh	Structure of a Bacterial Cyclic Nucleotide Regulated Ion Channel
3bpz	HCN2-I 443-460 E502K in the presence of cAMP
3cf6	Structure of Epac2 in complex with cyclic-AMP and Rap
3cl1	M. loti cyclic-nucleotide binding domain, cyclic-GMP bound
3clp	M. loti cyclic-nucleotide binding domain mutant 2
3co2	Mlotik1 ion channel cyclic-nucleotide binding domain mutant
3d0s	cAMP receptor protein from m.tuberculosis, cAMP-free form
3dkw	Crystal Structure of DNR from Pseudomonas aeruginosa.
3dn7	Cyclic nucleotide binding regulatory protein from Cytophaga hutchinsonii.
3dv8	Crystal structure of a putative transcriptional regulator of the crp/fnr family (eubrec_1222) from eubacterium rectale atcc 33656 at 2.55 A resolution
3e5q	Unbound Oxidised CprK
3e5u	OCPA complexed CprK (C200S)
3e5x	OCPA complexed CprK
3e6b	OCPA complexed CprK (C200S)
3e6c	CprK OCPA DNA Complex
3e6d	Crystal Structure of CprK C200S
3e97	Crystal structure of transcriptional regulator of Crp/Fnr family (YP_604437.1) from DEINOCOCCUS GEOTHERMALIS DSM 11300 at 1.86 A resolution
3etq	X-ray structure of cysteine-free fragment of mHCN2 C-terminal region from amino acids 443-630 including C508N, C584S, and C601S mutations
3ffq	HCN2I 443-640 apo-state
3fhi	Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA
3fwe	Crystal Structure of the Apo D138L CAP mutant
3fx3	Structure of a putative cAMP-binding regulatory protein from Silicibacter pomeroyi DSS-3
3gyd	Crystal structure of a cyclic nucleotide-binding domain (mfla_1926) from methylobacillus flagellatus kt at 1.79 A resolution
3h3u	Crystal structure of CRP (cAMP receptor Protein) from Mycobacterium tuberculosis
3h3z	Crystal structure of a putative cyclic nucleotide binding protein (spoa0323) from ruegeria pomeroyi dss-3 at 2.35 A resolution
3hif	The crystal structure of apo wild type CAP at 3.6 A resolution.
3i54	Crystal structure of MtbCRP in complex with cAMP
3i59	Crystal structure of MtbCRP in complex with N6-cAMP
3idb	Crystal structure of (108-268)RIIb:C holoenzyme of cAMP-dependent protein kinase
3idc	Crystal structure of (102-265)RIIb:C holoenzyme of cAMP-dependent protein kinase
3iia	Crystal structure of apo (91-244) RIa subunit of cAMP-dependent protein kinase
3iwz	The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris
3iyd	Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
3j4q	Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from electron microscopy
3j4r	Pseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopy
3kcc	Crystal structure of D138L mutant of Catabolite Gene Activator Protein
3la2	Crystal structure of NtcA in complex with 2-oxoglutarate
3la3	Crystal structure of NtcA in complex with 2,2-difluoropentanedioic acid
3la7	Crystal structure of NtcA in apo-form
3mdp	Crystal structure of a Putative Cyclic nucleotide-binding protein (Gmet_1532) from Geobacter metallireducens GS-15 at 1.90 A resolution
3mzh	Crystal structure of cAMP receptor protein from mycobacterium tuberculosis in complex with cAMP and its DNA binding element
3n4m	E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA
3ocp	Crystal structure of cAMP bound cGMP-dependent protein kinase(92-227)
3od0	Crystal structure of cGMP bound cGMP-dependent protein kinase(92-227)
3of1	Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA
3ogj	Crystal structure of partial apo (92-227) of cGMP-dependent protein kinase
3otf	Structural basis for the cAMP-dependent gating in human HCN4 channel
3plq	Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS
3pna	Crystal Structure of cAMP bound (91-244)RIa Subunit of cAMP-dependent Protein Kinase
3pvb	Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase
3qop	Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
3r6s	Crystal structure of GlxR transcription factor from Corynebacterium glutamicum with cAMP
3rdi	Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
3rou	Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
3rpq	Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
3ryp	Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
3ryr	Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
3shr	Crystal Structure of cGMP-dependent Protein Kinase Reveals Novel Site of Interchain Communication
3tnp	Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
3tnq	Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
3u0z	Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
3u10	Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
3u11	Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
3ukn	Structure of the C-linker/CNBHD of zELK channels in C 2 2 21 space group
3ukt	Structure of the C-linker/CNBHD of zELK channels in P1 21 1 space group
3ukv	Structure of the C-linker/CNBHD of zELK channels in P 1 21 1 space group, crystallized in the presence of cAMP
4a2u	CRP(CAP) from Myco. Tuberculosis, with cAMP
4ava	Crystal structure of protein lysine acetyltransferase Rv0998 from Mycobacterium tuberculosis
4avb	Crystal structure of protein lysine acetyltransferase Rv0998 in complex with acetyl CoA and cAMP
4avc	Crystal structure of protein lysine acetyltransferase Rv0998 in complex with acetyl CoA and cAMP
4bh9	A structural model of CAP mutant (T127L and S128I) in the apo state
4bhp	A structural model of CAP mutant (T127L and S128I) in cGMP-bound state
4byy	4BYY
4chv	The electron crystallography structure of the cAMP-bound potassium channel MloK1
4chw	The electron crystallography structure of the cAMP-free potassium channel MloK1
4cyd	4CYD
4d7s	4D7S
4d7t	4D7T
4din	Novel Localization and Quaternary Structure of the PKA RI beta Holoenzyme
4ev0	Crystal Structure of Thermus thermophilus Catabolite Activator Protein
4f7z	Conformational dynamics of exchange protein directly activated by cAMP
4f8a	Cyclic nucleotide binding-homology domain from mouse EAG1 potassium channel
4ft8	E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands
4hbn	Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation
4hzf	structure of the wild type Catabolite gene Activator Protein
4i01	Structure of the mutant Catabolite gen activator protein V140L
4i02	structure of the mutant Catabolite gene activator protein V140A
4i09	structure of the mutant Catabolite gene activator protein V132L
4i0a	structure of the mutant Catabolite gene activator protein V132A
4i0b	structure of the mutant Catabolite gene activator protein H160L
4i2o	The Structure of FixK2 from Bradyrhizobium japonicum
4jv4	Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog
4jva	Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog
4k8f	Structure of the heme domain of CooA from Rhodospirillum rubrum
4kg1	cGMP-responsive diguanylate cyclase
4kl1	HCN4 CNBD in complex with cGMP
4ku7	Structures of PKGI Reveal a cGMP-Selective Activation Mechanism
4ku8	Structures of PKGI Reveal a cGMP-Selective Activation Mechanism
4l11	Structure of the C-linker/CNBHD of agERG channels
4llo	Structure of the eag domain-CNBHD complex of the mouse EAG1 channel
4mgi	4MGI
4mgk	4MGK
4mgy	4MGY
4mgz	4MGZ
4mh0	4MH0
4muv	4MUV
4mx3	Crystal Structure of PKA RIalpha Homodimer
4n9h	4N9H
4n9i	4N9I
4nvp	Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP
4off	4OFF
4ofg	4OFG
4oll	cAMP-binding acyltransferase from Mycobacterium smegmatis
4onu	cAMP-binding acyltransferase from Mycobacterium smegmatis, E234A mutant
4orf	cAMP-binding acyltransferase from Mycobacterium smegmatis, mutant R95K
4qx5	4QX5
4qxk	4QXK
4r8h	4R8H
4rz7	4RZ7
4wbb	4WBB
4x6q	4X6Q
4x6r	4X6R
4z07	4Z07
5bv6	5BV6
5c6c	5C6C
5c8w	5C8W
5ciz	5CIZ
5cvr	5CVR
5d1i	5D1I
5dyk	5DYK
5dyl	5DYL
5dzc	5DZC
5e16	5E16
5e44	5E44
5f0a	5F0A
5fet	5FET
5i2d	5I2D
5j3u	5J3U
5jon	5JON
5k7l	5K7L
5k8s	5K8S
5kbf	5KBF
5khg	5KHG
5khh	5KHH
5khi	5KHI
5khj	5KHJ
5khk	5KHK
5t3n	5T3N

Links (links to other resources describing this domain)

• PFAM: cNMP_binding
• INTERPRO: IPR000595