fCBD Fungal-type cellulose-binding domain
SMART ACC:	SM000236
Description:	Small four-cysteine cellulose-binding domain of fungi
InterPro ACC:	IPR000254
InterPro abstract:	This entry represents the cellulose-binding domain (CBD) in monooxygenase, exoglucanase, cellobiohydrolase, endoglucanases and related enzymes, mainly from fungi. The microbial degradation of cellulose and xylans requires several types of enzymes, such as endoglucanases ( EC:3.2.1.4 ), cellobiohydrolases ( expand This entry represents the cellulose-binding domain (CBD) in monooxygenase, exoglucanase, cellobiohydrolase, endoglucanases and related enzymes, mainly from fungi. The microbial degradation of cellulose and xylans requires several types of enzymes, such as endoglucanases ( EC:3.2.1.4 ), cellobiohydrolases ( EC:3.2.1.91 ) (exoglucanases), or xylanases ( EC:3.2.1.8 ) [ PUBMED:1886523 ]. Structurally, cellulases and xylanases generally consist of a catalytic domain joined to a CBD by a short linker sequence rich in proline and/or hydroxy-amino acids. The CBD of several fungal cellulases has been shown to consist of 36 amino acid residues, and it is found either at the N-terminal or at the C-terminal extremity of the enzymes. As it is shown in the following schematic representation, there are four conserved cysteines in this type of CBD domain, all involved in disulphide bonds. +----------------+ \| +-----\|---------+ \| \| \| \| xxxxxxxCxxxxxxxxxxCxxxxxCxxxxxxxxxCx collapse
GO process:	carbohydrate metabolic process (GO:0005975)
GO component:	extracellular region (GO:0005576)
GO function:	cellulose binding (GO:0030248)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 5 841 fCBD domains in 5 233 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing fCBD domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing fCBD domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Binding / catalysis:	Cellulose-binding

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a fCBD domain which could be assigned to a KEGG orthologous group, and not all proteins containing fCBD domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR000254
PROSITE	CBD_FUNGAL
Pfam	CBD_fungal