The Pfam:SIR2 domain within your query sequence starts at position 214 and ends at position 400, and its E-value is 4e-63.

GAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRILQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRP
Pfam:SIR2

Pfam:SIR2
Pfam domain

Pfam ACC: