The Pfam:SIR2 domain within your query sequence starts at position 253 and ends at position 439, and its E-value is 6.5e-64.

GAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRILQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRP
Pfam:SIR2

Pfam:SIR2
Pfam domain

Pfam ACC: