Taxonomic distribution of proteins containing Cyclin_C domains

The Cyclin_C domain within your query sequence starts at position 297 and ends at position 378, and its E-value is 3.18e-10.

Cell cycle regulation and neural differentiation.

Galderisi U, Jori FP, Giordano A
Oncogene. 2003; 22: 5208-19

The general mechanisms that control the cell cycle in mammalian cells have beenstudied in depth and several proteins that are involved in the tight regulationof cell cycle progression have been identified. However, the analysis of whichmolecules participate in cell cycle exit of specific cell lineages is notexhaustive yet. Moreover, the strict relation between cell cycle exit andinduction of differentiation has not been fully understood and seems to depend onthe cell type. Several in vivo and in vitro studies have been performed in thelast few years to address these issues in cells of the nervous system. In thisreview, we focus our attention on cyclin-cyclin-dependent kinase complexes,cyclin kinase inhibitors, genes of the retinoblastoma family, p53 and N-Myc, and we aim to summarize the latest evidence indicating their involvement in thecontrol of the cell cycle and induction of differentiation in different celltypes of the peripheral and central nervous systems. Studies on nervous systemtumors and a possible contributory role in tumorigenesis of polyomavirus Tantigen are reported to point out the critical contribution of some cell cycleregulators to normal neural and glial development.