The GEL domain within your query sequence starts at position 1723 and ends at position 1824, and its E-value is 1.72e-17.
 GELGelsolin homology domain | |
|---|---|
| SMART ACC: | SM000262 |
| Description: | Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains. |
| InterPro ACC: | IPR007122 |
| InterPro abstract: | Gelsolin is an actin-modulating protein that severs F-actin, caps the barbed ends of actin filaments preventing monomer exchange, and promotes the nucleation step of actin polymerisation [ PUBMED:14527663 PUBMED:3023087 ]. It can be regulated … expand |
| GO function: | actin filament binding (GO:0051015) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 34 141 GEL domains in 8 112 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing GEL domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing GEL domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Binding / catalysis: | Calcium, actin |
|---|
Disease genes where sequence variants are found in this domain
UniRef sequences and OMIM curated human diseases associated with missense mutations within the GEL domain.
| Protein | Description | Disease / phenotype |
|---|---|---|
| GELS_HUMAN | OMIM:137350 : Amyloidosis, Finnish type | |
| OMIM:105120 : no description |
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a GEL domain which could be assigned to a KEGG orthologous group, and not all proteins containing GEL domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.