7TM_GPCR_Srsx

Serpentine type 7TM GPCR chemoreceptor Srsx
7TM_GPCR_Srsx
SMART accession number:SM01381
Description: Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type (PMID:7585938). Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise blind and deaf (PMID:18050473)
Interpro abstract (IPR000276):

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [(PUBMED:12679517)]. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence [(PUBMED:8170923)]. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [(PUBMED:8170923), (PUBMED:8081729), (PUBMED:15914470), (PUBMED:18948278), (PUBMED:16753280)]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice [(PUBMED:12679517)]. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [(PUBMED:23020293)].

The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [(PUBMED:2111655), (PUBMED:2830256), (PUBMED:8386361)].

This entry represents the G protein-coupled receptor, rhodopsin-like family.

GO process:G-protein coupled receptor signaling pathway (GO:0007186)
GO component:integral component of membrane (GO:0016021)
GO function:G-protein coupled receptor activity (GO:0004930)
Family alignment:
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There are 490 7TM_GPCR_Srsx domains in 466 proteins in SMART's nrdb database.

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