AGTRAP

Angiotensin II, type I receptor-associated protein
AGTRAP
SMART accession number:SM00805
Description: This family consists of several angiotensin II, type I receptor-associated protein (AGTRAP) sequences. AGTRAP is known to interact specifically with the C-terminal cytoplasmic region of the angiotensin II type 1 (AT(1)) receptor to regulate different aspects of AT(1) receptor physiology. The function of this family is unclear.
Interpro abstract (IPR009436):

AGTRAP (type-1 angiotensin II receptor-associated protein) appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation [(PUBMED:10358057)]. It plays an important role in cardiac hypertrophy [(PUBMED:15757644)].

GO process:angiotensin-activated signaling pathway (GO:0038166)
Family alignment:
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There are 490 AGTRAP domains in 490 proteins in SMART's nrdb database.

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