Aspzincin_M35

Lysine-specific metallo-endopeptidase
Aspzincin_M35
SMART accession number:SM01351
Description: This is the catalytic region of aspzincins, a group of lysine-specific metallo-endopeptidases in the M35 family. They exhibit the following active-site architecture. The active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In UniProt:P81054 His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner (PMID:11679721).
Family alignment:
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There are 205 Aspzincin_M35 domains in 205 proteins in SMART's nrdb database.

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