The domain within your query sequence starts at position 590 and ends at position 699; the E-value for the CRM1_C domain shown below is 1e-22.
KIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTV QEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRAC
The domain was found using the schnipsel database
CRM1_CCRM1 C terminal |
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SMART accession number: | SM01102 |
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Description: | CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat (PUBMED:15574331). |
Interpro abstract (IPR014877): | CRM1 (also known as exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This entry represents the C-terminal domain of CRM1. It forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat [ (PUBMED:15574331) ]. |
GO function: | nuclear export signal receptor activity (GO:0005049) |
Family alignment: |
There are 1759 CRM1_C domains in 1757 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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