The domain within your query sequence starts at position 132 and ends at position 177; the E-value for the OLF domain shown below is 2e-18.

QYKADTRTIVRLREEVRNLSGNLAAIQEEMGAYGYEDLQQRVMALE

The domain was found using the schnipsel database

OLF

Olfactomedin-like domains
OLF
SMART accession number:SM00284
Description: -
Interpro abstract (IPR003112):

The olfactomedin-like or OLF domain is a module of ~260 residues present in metazoan secreted glycoproteins with a characteristic tissue-specific expression. The domain is named after bullfrog olfactomedin, an extracellular matrix protein of olfactory neuroepithelium, whereof it forms the C-terminal part. Other proteins of the olfactomedin family contain the OLF domain in the C-terminal part, while the N terminus is more variable. Proteins of the latrophilin subfamily have an OLF domain in the N-terminal extracellular part, C-terminal to a SUEL-type lectin domain, and their C-terminal part contains domains of the G-protein coupled receptors family 2. Some OLF domain proteins are involved in the formation of the extracellular matrix, e.g. bullfrog olfactomedin, sea urchin amassin and C. elegans unc-122. In addition, OLF domain proteins can function in developmental processes, e.g. noelin and tiarin [(PUBMED:12019210), (PUBMED:11867215), (PUBMED:12615070), (PUBMED:15280020)].

Secondary structure predictions show that the OLF domain contains several beta-strands [(PUBMED:11867215), (PUBMED:12615070), (PUBMED:15280020)]. A disulfide bond between two conserved cysteines within the OLF domain of human myocilin is implicated in mutations associated with severe forms of primary open angle glaucoma [(PUBMED:12615070)].

Family alignment:
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There are 6142 OLF domains in 6140 proteins in SMART's nrdb database.

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