The domain within your query sequence starts at position 347 and ends at position 387; the E-value for the PlsC domain shown below is 7e-13.

Some of the required catalytic sites were not detected in this domain. It is probably inactive! Check the literature (PubMed 11377195 ) for details.

Catalytic residues
PositionAmino acidPresent?

The domain was found using the schnipsel database


Phosphate acyltransferases
SMART accession number:SM00563
Description: Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Interpro abstract (IPR002123):

This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [(PUBMED:9259571)]. This domain is found in tafazzins, defects in which are the cause of Barth syndrome; a severe inherited disorder which is often fatal in childhood and is characterised by cardiac and skeletal abnormalities. Phospholipid/glycerol acyltransferase is not found in the viruses or the archaea and is under represented in the bacteria. Bacterial glycerol-phosphate acyltransferases are involved in membrane biogenesis since they use fatty acid chains to form the first membrane phospholipids [(PUBMED:18369234)].

GO process:metabolic process (GO:0008152)
GO function:transferase activity, transferring acyl groups (GO:0016746)
Family alignment:
View or

There are 106677 PlsC domains in 106607 proteins in SMART's nrdb database.

Click on the following links for more information.