CCAAT-Binding transcription Factor
SMART accession number:SM00521
Description: -
Interpro abstract (IPR001289): The CCAAT-binding factor (CBFB/NF-YA) is a mammalian transcription factor that binds to a CCAAT motif in the promoters of a wide variety of genes, including type I collagen and albumin [(PUBMED:2266139)]. The factor is a heteromeric complex of A and B subunits, both of which are required for DNA-binding [(PUBMED:1549471)]. The subunits can interact in the absence of DNA-binding, conserved regions in each being important in mediating this interaction.

The B subunit contains a region of similarity with the yeast protein HAP2 [(PUBMED:2000400)]. For the B subunit it has been suggested that the N-terminal portion of the conserved region is involved in subunit interaction and the C-terminal region involved in DNA-binding [(PUBMED:1569083)].

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO function:sequence-specific DNA binding transcription factor activity (GO:0003700)
Family alignment:
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There are 688 CBF domains in 688 proteins in SMART's nrdb database.

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