The domain within your query sequence starts at position 208 and ends at position 302; the E-value for the CRA domain shown below is 7.07e-17.

TNQREALQYAKNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFT
RDACALLGLSVESPLSVSFSAGCVALPALINIKAV

CRA

CT11-RanBPM
CRA
SMART accession number:SM00757
Description: protein-protein interaction domain present in crown eukaryotes (plants, animals, fungi)
Interpro abstract (IPR013144):

This entry represents the CRA (or CT11-RanBPM) domain, which is a protein-protein interaction domain present in crown eukaryotes (plants, animals, fungi) and which is found in Ran-binding proteins such as Ran-binding protein 9 (RanBP9 or RanBPM) and RanBP10. RanBPM is a scaffolding protein important in regulating cellular function in both the immune system and the nervous system, and may act as an adapter protein to couple membrane receptors to intracellular signaling pathways. This domain is at the C terminus of the proteins and is the binding domain for the CRA motif, which is comprised of approximately 100 amino acids at the C-terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined [ (PUBMED:15381419) ].

Family alignment:
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There are 5980 CRA domains in 5977 proteins in SMART's nrdb database.

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