DUF1237

DUF1237
SMART accession number:SM01149
Description: This family contains a number of hypothetical proteins of about 450 residues in length. Their function is unknown, and most are bacterial. However, structurally this family is part of the 6 hairpin glycosidase superfamily, suggesting a glycosyl hydrolase function.
Interpro abstract (IPR008313): This family includes proteins from bacteria and fungi. It was originally identified as a protein of unknown function from Schizosaccharomyces pombe, which was isolated from a screen to identify novel genes required for meiosis [(PUBMED:16303567)]. Members of this family have since been characterised from Streptococcus pneumoniae (A0A0H2URZ6) and Clostridium perfringens (Q8XNB2), and represent a new glycoside hydrolase family, also known as GH125. This family is the first characterized metal-independent alpha-mannosidase family [(PUBMED:21388958)]. Proteins in this family have been reported to be strict exo-alpha-1,6-mannosidases that operate via a metal-independent inverting catalytic mechanism [(PUBMED:21388958)].
Family alignment:
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There are 3685 DUF1237 domains in 3685 proteins in SMART's nrdb database.

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