ECSIT_Cterm

C-terminal domain of the ECSIT protein
ECSIT_Cterm
SMART accession number:SM01284
Description: This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain.
Interpro abstract (IPR029342):

This entry represents the C-terminal domain of the evolutionarily conserved signalling intermediate in Toll pathway (ECSIT) protein, an adapter protein of the Toll/IL-1 receptor signalling pathway, which is involved in the activation of NF-kappa-B via MAP3K1 [(PUBMED:10465784)]. This domain is missing in isoform 2. This domain may be distantly homologous to the pleckstrin homology domain.

Family alignment:
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There are 546 ECSIT_Cterm domains in 544 proteins in SMART's nrdb database.

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