Endonuclease_NSDNA/RNA non-specific endonuclease |
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SMART accession number: | SM00892 |
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Description: | A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. An histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion. |
Interpro abstract (IPR001604): | A family of bacterial and eukaryotic endonucleases EC 3.1.30 share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. A histidine has been shown [(PUBMED:8078761)] to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion. |
GO function: | hydrolase activity (GO:0016787), metal ion binding (GO:0046872), nucleic acid binding (GO:0003676) |
Family alignment: |
There are 4175 Endonuclease_NS domains in 4129 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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