FISNA

Fish-specific NACHT associated domain
FISNA
SMART accession number:SM01288
Description: This domain is frequently found associated with the NACHT domain (PFAM: PF05729) in fish and other vertebrates PMID:18039395.
Interpro abstract (IPR029495):

This domain is frequently found associated with the NACHT domain (IPR007111) in fish and other vertebrates [(PUBMED:18039395)]. Proteins containing this domain include NACHT, LRR and PYD domains-containing protein 3/12 (NLRP3/12). In humans, NLRP3 (also known as PYPAF1) may function as an inducer of apoptosis [(PUBMED:11786556)]. NLRP12 is a non-inflammasome NLR (nucleotide-binding domain and leucine-rich repeat-containing receptors) that has been implicated in the regulation of Toll-like receptor-dependent nuclear factor-kappaB activation [(PUBMED:21978668)].

Family alignment:
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There are 5755 FISNA domains in 5693 proteins in SMART's nrdb database.

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