C-terminal duplication domain of Friend of PRMT1
SMART accession number:SM01218
Description: Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it colocalises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation (PUBMED:19858291).
Family alignment:
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There are 964 FoP_duplication domains in 962 proteins in SMART's nrdb database.

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