G-protein-coupled receptor proteolytic site domain
SMART accession number:SM00303
Description: Present in latrophilin/CL-1, sea urchin REJ and polycystin.
Interpro abstract (IPR000203):

This motif has been termed GPS (for GPCR proteolytic site), because it contains a cleavage site in O97830 latrophilin [(PUBMED:9920906)]. This motif is also found in many otherwise unrelated cell surface receptors [(PUBMED:10469603)].

GPS motifs are about 50 residues long and contain either 2 or 4 cysteine residues that are likely to form disulphide bridges. Based on conservation of these cysteines the following pairing can be predicted.

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+-----------------+---------------+ |
| | | |
cleavage site
The GPS motif is an integral part of a much larger (320-residue approximately) domain that has been termed GPCR-Autoproteolysis INducing (GAIN) domain. The GAIN domain represents an autoproteolytic fold whose function is likely relevant for GPCR signalling [(PUBMED:22333914)].
GO component:membrane (GO:0016020)
Family alignment:
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There are 4920 GPS domains in 4890 proteins in SMART's nrdb database.

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