helix_turn_helix, Deoxyribose operon repressor
SMART accession number:SM00420
Interpro abstract (IPR001034):

The deoR-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 amino acids present in transcription regulators of the deoR family, involved in sugar catabolism. This family of prokaryotic regulators is named after the Escherichia coli protein DeoR, a repressor of the deo operon, which encodes nucleotide and deoxyribonucleotide catabolic enzymes. DeoR also negatively regulates the expression of nupG and tsx, a nucleoside-specific transport protein and a channel-forming protein, respectively.

DeoR-like transcription repressors occur in diverse bacteria as regulators of sugar and nucleoside metabolic systems. The effector molecules for deoR-like regulators are generally phosphorylated intermediates of the relevant metabolic pathway. The DNA-binding deoR-type HTH domain occurs usually in the N-terminal part. The C-terminal part can contain an effector-binding domain and/or an oligomerisation domain. DeoR occurs as an octamer, whilst glpR and agaR are tetramers. Several operators may be bound simultaneously, which could facilitate DNA looping [(PUBMED:1731335), (PUBMED:14731281)].

GO process:regulation of transcription, DNA-dependent (GO:0006355)
GO component:intracellular (GO:0005622)
GO function:sequence-specific DNA binding transcription factor activity (GO:0003700)
Family alignment:
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There are 4409 HTH_DEOR domains in 4407 proteins in SMART's nrdb database.

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