HTH_DEOR

helix_turn_helix, Deoxyribose operon repressor

• SMART accession number: SM00420
• Interpro abstract (IPR001034):

  The deoR-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 amino acids present in transcription regulators of the deoR family, involved in sugar catabolism. This family of prokaryotic regulators is named after the Escherichia coli protein DeoR, a repressor of the deo operon, which encodes nucleotide and deoxyribonucleotide catabolic enzymes. DeoR also negatively regulates the expression of nupG and tsx, a nucleoside-specific transport protein and a channel-forming protein, respectively.

  DeoR-like transcription repressors occur in diverse bacteria as regulators of sugar and nucleoside metabolic systems. The effector molecules for deoR-like regulators are generally phosphorylated intermediates of the relevant metabolic pathway. The DNA-binding deoR-type HTH domain occurs usually in the N-terminal part. The C-terminal part can contain an effector-binding domain and/or an oligomerisation domain. DeoR occurs as an octamer, whilst glpR and agaR are tetramers. Several operators may be bound simultaneously, which could facilitate DNA looping [(PUBMED:1731335), (PUBMED:14731281)].

• GO process: regulation of transcription, DNA-dependent (GO:0006355)
• GO component: intracellular (GO:0005622)
• GO function: sequence-specific DNA binding transcription factor activity (GO:0003700)

There are 4409 HTH_DEOR domains in 4407 proteins in SMART's nrdb database.

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Valentin-Hansen P, Hojrup P, Short S
• The primary structure of the DeoR repressor from Escherichia coli K-12.
• Nucleic Acids Res. 1985; 13: 5927-36

The nucleotide sequence of the deoR gene of E. coli, which codes for the DeoR repressor, has been determined. This gene codes for a polypeptide that is 252 amino acids residues in length. Computer-assisted analysis of the nucleotide sequence strongly suggests that the DNA binding domain of the DeoR repressor is located in the N-terminal part of the protein. After the coding region there is a dyad symmetry similar to a palindromic unit present outside many structural genes on the E. coli chromosome.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
33.33	map00051	Fructose and mannose metabolism
16.67	map00970	Aminoacyl-tRNA biosynthesis
16.67	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
16.67	map03020	RNA polymerase
16.67	map02020	Two-component system - General

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with HTH_DEOR domain which could be assigned to a KEGG orthologous group, and not all proteins containing HTH_DEOR domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Links (links to other resources describing this domain)

• PFAM: deoR
• INTERPRO: IPR001034
• PROSITE: HTH_DEOR_FAMIL