The domain within your query sequence starts at position 706 and ends at position 743; the E-value for the IKKbetaNEMObind domain shown below is 1.64e-15.

LAQMIEENLNCLGHLSTIIREANEDQSSSLMSLDWSWL

IKKbetaNEMObind

I-kappa-kinase-beta NEMO binding domain
IKKbetaNEMObind
SMART accession number:SM01239
Description: This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with S_TKc. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.
Interpro abstract (IPR022007):

This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.

GO function:IkappaB kinase activity (GO:0008384)
Family alignment:
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There are 606 IKKbetaNEMObind domains in 603 proteins in SMART's nrdb database.

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